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Gut microbiome remodeling and metabolomic profile improves in response to protein pacing with intermittent fasting versus continuous caloric restriction

Author

Listed:
  • Alex E. Mohr

    (Arizona State University
    Arizona State University)

  • Karen L. Sweazea

    (Arizona State University
    Arizona State University
    Arizona State University)

  • Devin A. Bowes

    (Arizona State University)

  • Paniz Jasbi

    (Arizona State University
    Theriome Inc.)

  • Corrie M. Whisner

    (Arizona State University
    Arizona State University)

  • Dorothy D. Sears

    (Arizona State University)

  • Rosa Krajmalnik-Brown

    (Arizona State University)

  • Yan Jin

    (Florida International University)

  • Haiwei Gu

    (Arizona State University
    Florida International University)

  • Judith Klein-Seetharaman

    (Arizona State University
    Arizona State University)

  • Karen M. Arciero

    (Skidmore College)

  • Eric Gumpricht

    (LLC)

  • Paul J. Arciero

    (Skidmore College
    University of Pittsburgh)

Abstract

The gut microbiome (GM) modulates body weight/composition and gastrointestinal functioning; therefore, approaches targeting resident gut microbes have attracted considerable interest. Intermittent fasting (IF) and protein pacing (P) regimens are effective in facilitating weight loss (WL) and enhancing body composition. However, the interrelationships between IF- and P-induced WL and the GM are unknown. The current randomized controlled study describes distinct fecal microbial and plasma metabolomic signatures between combined IF-P (n = 21) versus a heart-healthy, calorie-restricted (CR, n = 20) diet matched for overall energy intake in free-living human participants (women = 27; men = 14) with overweight/obesity for 8 weeks. Gut symptomatology improves and abundance of Christensenellaceae microbes and circulating cytokines and amino acid metabolites favoring fat oxidation increase with IF-P (p

Suggested Citation

  • Alex E. Mohr & Karen L. Sweazea & Devin A. Bowes & Paniz Jasbi & Corrie M. Whisner & Dorothy D. Sears & Rosa Krajmalnik-Brown & Yan Jin & Haiwei Gu & Judith Klein-Seetharaman & Karen M. Arciero & Eric, 2024. "Gut microbiome remodeling and metabolomic profile improves in response to protein pacing with intermittent fasting versus continuous caloric restriction," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48355-5
    DOI: 10.1038/s41467-024-48355-5
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    1. David Zeevi & Tal Korem & Anastasia Godneva & Noam Bar & Alexander Kurilshikov & Maya Lotan-Pompan & Adina Weinberger & Jingyuan Fu & Cisca Wijmenga & Alexandra Zhernakova & Eran Segal, 2019. "Structural variation in the gut microbiome associates with host health," Nature, Nature, vol. 568(7750), pages 43-48, April.
    2. Koji Atarashi & Takeshi Tanoue & Kenshiro Oshima & Wataru Suda & Yuji Nagano & Hiroyoshi Nishikawa & Shinji Fukuda & Takuro Saito & Seiko Narushima & Koji Hase & Sangwan Kim & Joëlle V. Fritz & Paul W, 2013. "Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota," Nature, Nature, vol. 500(7461), pages 232-236, August.
    3. Catherine A. Lozupone & Jesse I. Stombaugh & Jeffrey I. Gordon & Janet K. Jansson & Rob Knight, 2012. "Diversity, stability and resilience of the human gut microbiota," Nature, Nature, vol. 489(7415), pages 220-230, September.
    4. Junjie Qin & Ruiqiang Li & Jeroen Raes & Manimozhiyan Arumugam & Kristoffer Solvsten Burgdorf & Chaysavanh Manichanh & Trine Nielsen & Nicolas Pons & Florence Levenez & Takuji Yamada & Daniel R. Mende, 2010. "A human gut microbial gene catalogue established by metagenomic sequencing," Nature, Nature, vol. 464(7285), pages 59-65, March.
    5. Feng He & Li Zuo & Emery Ward & Paul J. Arciero, 2017. "Serum Polychlorinated Biphenyls Increase and Oxidative Stress Decreases with a Protein-Pacing Caloric Restriction Diet in Obese Men and Women," IJERPH, MDPI, vol. 14(1), pages 1-18, January.
    6. Reiner Jumpertz Schwartzenberg & Jordan E. Bisanz & Svetlana Lyalina & Peter Spanogiannopoulos & Qi Yan Ang & Jingwei Cai & Sophia Dickmann & Marie Friedrich & Su-Yang Liu & Stephanie L. Collins & Dan, 2021. "Caloric restriction disrupts the microbiota and colonization resistance," Nature, Nature, vol. 595(7866), pages 272-277, July.
    7. Koji Hosomi & Mayu Saito & Jonguk Park & Haruka Murakami & Naoko Shibata & Masahiro Ando & Takahiro Nagatake & Kana Konishi & Harumi Ohno & Kumpei Tanisawa & Attayeb Mohsen & Yi-An Chen & Hitoshi Kawa, 2022. "Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
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