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Human gut microbes impact host serum metabolome and insulin sensitivity

Author

Listed:
  • Helle Krogh Pedersen

    (Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark)

  • Valborg Gudmundsdottir

    (Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark)

  • Henrik Bjørn Nielsen

    (Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark)

  • Tuulia Hyotylainen

    (University of Örebro
    Turku Centre for Biotechnology, University of Turku and Åbo Akademi University
    VTT Technical Research Centre of Finland)

  • Trine Nielsen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Benjamin A. H. Jensen

    (Laboratory of Genomics and Molecular Biomedicine, University of Copenhagen)

  • Kristoffer Forslund

    (European Molecular Biology Laboratory)

  • Falk Hildebrand

    (European Molecular Biology Laboratory
    Vrije Universiteit Brussel
    Center for the Biology of Disease, VIB)

  • Edi Prifti

    (MGP MetaGénoPolis, INRA, Université Paris-Saclay
    Institute of Cardiometabolism and Nutrition (ICAN))

  • Gwen Falony

    (Center for the Biology of Disease, VIB
    Rega Institute)

  • Emmanuelle Le Chatelier

    (MGP MetaGénoPolis, INRA, Université Paris-Saclay)

  • Florence Levenez

    (MGP MetaGénoPolis, INRA, Université Paris-Saclay)

  • Joel Doré

    (MGP MetaGénoPolis, INRA, Université Paris-Saclay
    Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay)

  • Ismo Mattila

    (VTT Technical Research Centre of Finland
    Steno Diabetes Center)

  • Damian R. Plichta

    (Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark)

  • Päivi Pöhö

    (VTT Technical Research Centre of Finland
    Faculty of Pharmacy, University of Helsinki)

  • Lars I. Hellgren

    (Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark)

  • Manimozhiyan Arumugam

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Shinichi Sunagawa

    (European Molecular Biology Laboratory
    Institute of Microbiology)

  • Sara Vieira-Silva

    (Center for the Biology of Disease, VIB
    Rega Institute)

  • Torben Jørgensen

    (Faculty of Health and Medical Sciences, University of Copenhagen
    Research Centre for Prevention and Health, Centre for Health, Capital region, Glostrup Hospital)

  • Jacob Bak Holm

    (Laboratory of Genomics and Molecular Biomedicine, University of Copenhagen)

  • Kajetan Trošt

    (Steno Diabetes Center)

  • MetaHIT Consortium
  • Karsten Kristiansen

    (Laboratory of Genomics and Molecular Biomedicine, University of Copenhagen
    BGI-Shenzhen)

  • Susanne Brix

    (Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark)

  • Jeroen Raes

    (Vrije Universiteit Brussel
    Center for the Biology of Disease, VIB
    Rega Institute)

  • Jun Wang

    (Laboratory of Genomics and Molecular Biomedicine, University of Copenhagen
    BGI-Shenzhen
    Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University
    Macau University of Science and Technology)

  • Torben Hansen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
    Faculty of Health Sciences, University of Southern Denmark)

  • Peer Bork

    (European Molecular Biology Laboratory
    Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory
    Max Delbrück Centre for Molecular Medicine
    University of Wuerzburg)

  • Søren Brunak

    (Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark
    Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Matej Oresic

    (Turku Centre for Biotechnology, University of Turku and Åbo Akademi University
    VTT Technical Research Centre of Finland
    Steno Diabetes Center)

  • S. Dusko Ehrlich

    (MGP MetaGénoPolis, INRA, Université Paris-Saclay
    King’s College London, Centre for Host–Microbiome Interactions, Dental Institute Central Office, Guy’s Hospital)

  • Oluf Pedersen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
    Faculty of Health and Medical Sciences, University of Copenhagen)

Abstract

Increased potential for branched-chain amino acid and lipopolysaccharide biosynthesis in the gut microbiome of insulin-resistant individuals suggests that changes in the serum metabolome induced by dysbiosis, and driven by only a handful of species, contribute to the development of diabetes.

Suggested Citation

  • Helle Krogh Pedersen & Valborg Gudmundsdottir & Henrik Bjørn Nielsen & Tuulia Hyotylainen & Trine Nielsen & Benjamin A. H. Jensen & Kristoffer Forslund & Falk Hildebrand & Edi Prifti & Gwen Falony & E, 2016. "Human gut microbes impact host serum metabolome and insulin sensitivity," Nature, Nature, vol. 535(7612), pages 376-381, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7612:d:10.1038_nature18646
    DOI: 10.1038/nature18646
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    Cited by:

    1. Aibo Gao & Junlei Su & Ruixin Liu & Shaoqian Zhao & Wen Li & Xiaoqiang Xu & Danjie Li & Juan Shi & Bin Gu & Juan Zhang & Qi Li & Xiaolin Wang & Yifei Zhang & Yu Xu & Jieli Lu & Guang Ning & Jie Hong &, 2021. "Sexual dimorphism in glucose metabolism is shaped by androgen-driven gut microbiome," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Koen F. Dekkers & Sergi Sayols-Baixeras & Gabriel Baldanzi & Christoph Nowak & Ulf Hammar & Diem Nguyen & Georgios Varotsis & Louise Brunkwall & Nynne Nielsen & Aron C. Eklund & Jacob Bak Holm & H. Bj, 2022. "An online atlas of human plasma metabolite signatures of gut microbiome composition," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Kristin M. Ham & Layne K. Bower & Shanping Li & Hernan Lorenzi & Safiatou Doumbo & Didier Doumtabe & Kassoum Kayentao & Aissata Ongoiba & Boubacar Traore & Peter D. Crompton & Nathan W. Schmidt, 2024. "The gut microbiome is associated with susceptibility to febrile malaria in Malian children," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Ayya Keshet & Eran Segal, 2024. "Identification of gut microbiome features associated with host metabolic health in a large population-based cohort," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Maya Izumi & Kazuo Sonoki & Sumio Akifusa, 2022. "Correlation of Salivary Occult Blood with the Plasma Concentration of Branched-Chain Amino Acids: A Cross-Sectional Study," IJERPH, MDPI, vol. 19(15), pages 1-7, July.
    6. Osama S. Ali & Walaa G. Hozayen & Abdulwahab S. Almutairi & Sherif A. Edris & Aala A. Abulfaraj & Amged A. Ouf & Hamada M. Mahmoud, 2021. "Metagenomic Analysis Reveals the Fate of Antibiotic Resistance Genes in a Full-Scale Wastewater Treatment Plant in Egypt," Sustainability, MDPI, vol. 13(20), pages 1-19, October.
    7. Efrat Muller & Itamar Shiryan & Elhanan Borenstein, 2024. "Multi-omic integration of microbiome data for identifying disease-associated modules," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    8. Feng Tong & Teng Wang & Na L. Gao & Ziying Liu & Kuiqing Cui & Yiqian Duan & Sicheng Wu & Yuhong Luo & Zhipeng Li & Chengjian Yang & Yixue Xu & Bo Lin & Liguo Yang & Alfredo Pauciullo & Deshun Shi & G, 2022. "The microbiome of the buffalo digestive tract," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    9. Yonggan Sun & Qixing Nie & Shanshan Zhang & Huijun He & Sheng Zuo & Chunhua Chen & Jingrui Yang & Haihong Chen & Jielun Hu & Song Li & Jiaobo Cheng & Baojie Zhang & Zhitian Zheng & Shijie Pan & Ping H, 2023. "Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    10. Valerio Rosato & Mario Masarone & Marcello Dallio & Alessandro Federico & Andrea Aglitti & Marcello Persico, 2019. "NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome," IJERPH, MDPI, vol. 16(18), pages 1-26, September.

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