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Potentiating hypoxic microenvironment for antibiotic activation by photodynamic therapy to combat bacterial biofilm infections

Author

Listed:
  • Weijun Xiu

    (Nanjing University of Posts and Telecommunications)

  • Ling Wan

    (Nanjing University of Posts and Telecommunications)

  • Kaili Yang

    (Nanjing University of Posts and Telecommunications)

  • Xiao Li

    (Nanjing University of Posts and Telecommunications)

  • Lihui Yuwen

    (Nanjing University of Posts and Telecommunications)

  • Heng Dong

    (Medicine School of Nanjing University)

  • Yongbin Mou

    (Medicine School of Nanjing University)

  • Dongliang Yang

    (Nanjing Tech University)

  • Lianhui Wang

    (Nanjing University of Posts and Telecommunications)

Abstract

Traditional antibiotic treatment has limited efficacy for the drug-tolerant bacteria present in biofilms because of their unique metabolic conditions in the biofilm infection microenvironment. Modulating the biofilm infection microenvironment may influence the metabolic state of the bacteria and provide alternative therapeutic routes. In this study, photodynamic therapy is used not only to eradicate methicillin-resistant Staphylococcus aureus biofilms in the normoxic condition, but also to potentiate the hypoxic microenvironment, which induces the anaerobic metabolism of methicillin-resistant Staphylococcus aureus and activates the antibacterial activity of metronidazole. Moreover, the photodynamic therapy-activated chemotherapy can polarize the macrophages to a M2-like phenotype and promote the repair of the biofilm infected wounds in mice. This biofilm infection microenvironment modulation strategy, whereby the hypoxic microenvironment is potentiated to synergize photodynamic therapy with chemotherapy, provides an alternative pathway for efficient treatment of biofilm-associated infections.

Suggested Citation

  • Weijun Xiu & Ling Wan & Kaili Yang & Xiao Li & Lihui Yuwen & Heng Dong & Yongbin Mou & Dongliang Yang & Lianhui Wang, 2022. "Potentiating hypoxic microenvironment for antibiotic activation by photodynamic therapy to combat bacterial biofilm infections," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31479-x
    DOI: 10.1038/s41467-022-31479-x
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    References listed on IDEAS

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    1. Kyle R. Allison & Mark P. Brynildsen & James J. Collins, 2011. "Metabolite-enabled eradication of bacterial persisters by aminoglycosides," Nature, Nature, vol. 473(7346), pages 216-220, May.
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    Cited by:

    1. Li Yang & Dan Zhang & Wenjing Li & Hongbing Lin & Chendi Ding & Qingyun Liu & Liangliang Wang & Zimu Li & Lin Mei & Hongzhong Chen & Yanli Zhao & Xiaowei Zeng, 2023. "Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Jiahao Zhuang & Guobin Qi & Yecheng Feng & Min Wu & Hang Zhang & Dandan Wang & Xianhe Zhang & Kok Chan Chong & Bowen Li & Shitai Liu & Jianwu Tian & Yi Shan & Duo Mao & Bin Liu, 2024. "Thymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    3. Jian Cheng & Guihai Gan & Shaoqiu Zheng & Guoying Zhang & Chen Zhu & Shiyong Liu & Jinming Hu, 2023. "Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Zehui Wang & Anhua Wu & Wen Cheng & Yuhe Li & Dingxuan Li & Lai Wang & Xinfu Zhang & Yi Xiao, 2023. "Adoptive macrophage directed photodynamic therapy of multidrug-resistant bacterial infection," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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