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A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice

Author

Listed:
  • Solomiia Korchynska

    (Medical University of Vienna)

  • Patrick Rebernik

    (Medical University of Vienna)

  • Marko Pende

    (Medical University of Vienna
    Technical University of Vienna)

  • Laura Boi

    (Karolinska Institutet)

  • Alán Alpár

    (Semmelweis University
    Hungarian Academy of Sciences)

  • Ramon Tasan

    (Medical University Innsbruck)

  • Klaus Becker

    (Medical University of Vienna
    Technical University of Vienna)

  • Kira Balueva

    (Christian-Albrechts-University)

  • Saiedeh Saghafi

    (Technical University of Vienna)

  • Peer Wulff

    (Christian-Albrechts-University)

  • Tamas L. Horvath

    (Yale School of Medicine)

  • Gilberto Fisone

    (Karolinska Institutet)

  • Hans-Ulrich Dodt

    (Medical University of Vienna
    Technical University of Vienna)

  • Tomas Hökfelt

    (Karolinska Institutet)

  • Tibor Harkany

    (Medical University of Vienna
    Karolinska Institutet)

  • Roman A. Romanov

    (Medical University of Vienna)

Abstract

The lateral septum (LS) has been implicated in the regulation of locomotion. Nevertheless, the neurons synchronizing LS activity with the brain’s clock in the suprachiasmatic nucleus (SCN) remain unknown. By interrogating the molecular, anatomical and physiological heterogeneity of dopamine neurons of the periventricular nucleus (PeVN; A14 catecholaminergic group), we find that Th+/Dat1+ cells from its anterior subdivision innervate the LS in mice. These dopamine neurons receive dense neuropeptidergic innervation from the SCN. Reciprocal viral tracing in combination with optogenetic stimulation ex vivo identified somatostatin-containing neurons in the LS as preferred synaptic targets of extrahypothalamic A14 efferents. In vivo chemogenetic manipulation of anterior A14 neurons impacted locomotion. Moreover, chemogenetic inhibition of dopamine output from the anterior PeVN normalized amphetamine-induced hyperlocomotion, particularly during sedentary periods. Cumulatively, our findings identify a hypothalamic locus for the diurnal control of locomotion and pinpoint a midbrain-independent cellular target of psychostimulants.

Suggested Citation

  • Solomiia Korchynska & Patrick Rebernik & Marko Pende & Laura Boi & Alán Alpár & Ramon Tasan & Klaus Becker & Kira Balueva & Saiedeh Saghafi & Peer Wulff & Tamas L. Horvath & Gilberto Fisone & Hans-Ulr, 2022. "A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33584-3
    DOI: 10.1038/s41467-022-33584-3
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    1. Maja Zupančič & Erik Keimpema & Evgenii O. Tretiakov & Stephanie J. Eder & Itamar Lev & Lukas Englmaier & Pradeep Bhandari & Simone A. Fietz & Wolfgang Härtig & Estelle Renaux & Andreas Villunger & To, 2024. "Concerted transcriptional regulation of the morphogenesis of hypothalamic neurons by ONECUT3," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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