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An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

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  • Michael J. Krashes

    (Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
    Present addresses: Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA (M.J.K.); National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA (M.J.K.); Cardiovascular and Metabolic Diseases, Pfizer, 610 Main Street, Cambridge, Massachusetts 02139, USA (B.P.S.); Division of Pediatric Endocrinology, Departments of Pediatrics, University of Michigan, Ann Arbor, Michigan 48105, USA (D.P.O.); Cardiovascular and Metabolic Diseases, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, Massachusetts 02139, USA (L.V.).)

  • Bhavik P. Shah

    (Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
    Present addresses: Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA (M.J.K.); National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA (M.J.K.); Cardiovascular and Metabolic Diseases, Pfizer, 610 Main Street, Cambridge, Massachusetts 02139, USA (B.P.S.); Division of Pediatric Endocrinology, Departments of Pediatrics, University of Michigan, Ann Arbor, Michigan 48105, USA (D.P.O.); Cardiovascular and Metabolic Diseases, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, Massachusetts 02139, USA (L.V.).)

  • Joseph C. Madara

    (Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • David P. Olson

    (Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
    Present addresses: Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA (M.J.K.); National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA (M.J.K.); Cardiovascular and Metabolic Diseases, Pfizer, 610 Main Street, Cambridge, Massachusetts 02139, USA (B.P.S.); Division of Pediatric Endocrinology, Departments of Pediatrics, University of Michigan, Ann Arbor, Michigan 48105, USA (D.P.O.); Cardiovascular and Metabolic Diseases, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, Massachusetts 02139, USA (L.V.).)

  • David E. Strochlic

    (Harvard Medical School
    Program in Neuroscience, Harvard Medical School)

  • Alastair S. Garfield

    (Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
    Center for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK)

  • Linh Vong

    (Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
    Present addresses: Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA (M.J.K.); National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA (M.J.K.); Cardiovascular and Metabolic Diseases, Pfizer, 610 Main Street, Cambridge, Massachusetts 02139, USA (B.P.S.); Division of Pediatric Endocrinology, Departments of Pediatrics, University of Michigan, Ann Arbor, Michigan 48105, USA (D.P.O.); Cardiovascular and Metabolic Diseases, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, Massachusetts 02139, USA (L.V.).)

  • Hongjuan Pei

    (University of Michigan)

  • Mitsuko Watabe-Uchida

    (Center for Brain Science, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA)

  • Naoshige Uchida

    (Program in Neuroscience, Harvard Medical School
    Center for Brain Science, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA)

  • Stephen D. Liberles

    (Harvard Medical School
    Program in Neuroscience, Harvard Medical School)

  • Bradford B. Lowell

    (Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
    Program in Neuroscience, Harvard Medical School)

Abstract

The AgRP-expressing neurons in the arcuate nucleus drive food-seeking behaviours during caloric restriction; a mouse study of monosynaptic retrograde rabies spread and optogenetic circuit mapping reveals that these neurons are activated by input from hypothalamic paraventricular nucleus cells and their activation or inhibition can modulate feeding behaviour.

Suggested Citation

  • Michael J. Krashes & Bhavik P. Shah & Joseph C. Madara & David P. Olson & David E. Strochlic & Alastair S. Garfield & Linh Vong & Hongjuan Pei & Mitsuko Watabe-Uchida & Naoshige Uchida & Stephen D. Li, 2014. "An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger," Nature, Nature, vol. 507(7491), pages 238-242, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7491:d:10.1038_nature12956
    DOI: 10.1038/nature12956
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    Cited by:

    1. Solomiia Korchynska & Patrick Rebernik & Marko Pende & Laura Boi & Alán Alpár & Ramon Tasan & Klaus Becker & Kira Balueva & Saiedeh Saghafi & Peer Wulff & Tamas L. Horvath & Gilberto Fisone & Hans-Ulr, 2022. "A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Takashi Nagashima & Suguru Tohyama & Kaori Mikami & Masashi Nagase & Mieko Morishima & Atsushi Kasai & Hitoshi Hashimoto & Ayako M. Watabe, 2022. "Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Mingming Xing & Yang Li & Yuqi Zhang & Juemou Zhou & Danting Ma & Mengqi Zhang & Minglei Tang & Ting Ouyang & Fumiao Zhang & Xiaofeng Shi & Jianyuan Sun & Zuxin Chen & Weiping J. Zhang & Shuli Zhang &, 2024. "Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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