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The subcellular organization of neocortical excitatory connections

Author

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  • Leopoldo Petreanu

    (Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA)

  • Tianyi Mao

    (Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA)

  • Scott M. Sternson

    (Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA)

  • Karel Svoboda

    (Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA)

Abstract

Cortical mapping: subcellular organization The mapping of neuronal connections in the cerebral cortex has traditionally relied on electrophysiological recordings performed on brain slices, in which long-range connections are severed. Karel Svoboda and colleagues have now adapted a recent optogenetic method to map long-range inputs onto various segments of the dendritic arbours of cortical pyramidal neurons. They find that specific inputs tend to cluster in distinct domains within dendritic trees. Such spatial segregation of different axonal inputs within dendrites may strengthen coupling of coherent cell populations during neuronal information processing and learning.

Suggested Citation

  • Leopoldo Petreanu & Tianyi Mao & Scott M. Sternson & Karel Svoboda, 2009. "The subcellular organization of neocortical excitatory connections," Nature, Nature, vol. 457(7233), pages 1142-1145, February.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7233:d:10.1038_nature07709
    DOI: 10.1038/nature07709
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    1. Simon Weiler & Vahid Rahmati & Marcel Isstas & Johann Wutke & Andreas Walter Stark & Christian Franke & Jürgen Graf & Christian Geis & Otto W. Witte & Mark Hübener & Jürgen Bolz & Troy W. Margrie & Kn, 2024. "A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    2. Weiwei Guo & Sijia Fan & Dan Xiao & Hui Dong & Guangwei Xu & Zhikun Wan & Yuqian Ma & Zhen Wang & Tian Xue & Yifeng Zhou & Yulong Li & Wei Xiong, 2021. "A Brainstem reticulotegmental neural ensemble drives acoustic startle reflexes," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Yanjie Wang & Zhaonan Chen & Guofen Ma & Lizhao Wang & Yanmei Liu & Meiling Qin & Xiang Fei & Yifan Wu & Min Xu & Siyu Zhang, 2023. "A frontal transcallosal inhibition loop mediates interhemispheric balance in visuospatial processing," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    4. Sergio Luengo-Sanchez & Isabel Fernaud-Espinosa & Concha Bielza & Ruth Benavides-Piccione & Pedro Larrañaga & Javier DeFelipe, 2018. "3D morphology-based clustering and simulation of human pyramidal cell dendritic spines," PLOS Computational Biology, Public Library of Science, vol. 14(6), pages 1-22, June.
    5. Hironobu Osaki & Moeko Kanaya & Yoshifumi Ueta & Mariko Miyata, 2022. "Distinct nociception processing in the dysgranular and barrel regions of the mouse somatosensory cortex," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    6. Yoav Printz & Pritish Patil & Mathias Mahn & Asaf Benjamin & Anna Litvin & Rivka Levy & Max Bringmann & Ofer Yizhar, 2023. "Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    7. Solomiia Korchynska & Patrick Rebernik & Marko Pende & Laura Boi & Alán Alpár & Ramon Tasan & Klaus Becker & Kira Balueva & Saiedeh Saghafi & Peer Wulff & Tamas L. Horvath & Gilberto Fisone & Hans-Ulr, 2022. "A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    8. Yanmei Liu & Jiahe Zhang & Zhishan Jiang & Meiling Qin & Min Xu & Siyu Zhang & Guofen Ma, 2024. "Organization of corticocortical and thalamocortical top-down inputs in the primary visual cortex," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    9. Shan Shen & Xiaolong Jiang & Federico Scala & Jiakun Fu & Paul Fahey & Dmitry Kobak & Zhenghuan Tan & Na Zhou & Jacob Reimer & Fabian Sinz & Andreas S. Tolias, 2022. "Distinct organization of two cortico-cortical feedback pathways," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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