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Flexible cue anchoring strategies enable stable head direction coding in both sighted and blind animals

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  • Kadjita Asumbisa

    (McGill University)

  • Adrien Peyrache

    (McGill University)

  • Stuart Trenholm

    (McGill University)

Abstract

Vision plays a crucial role in instructing the brain’s spatial navigation systems. However, little is known about how vision loss affects the neuronal encoding of spatial information. Here, recording from head direction (HD) cells in the anterior dorsal nucleus of the thalamus in mice, we find stable and robust HD tuning in rd1 mice, a model of photoreceptor degeneration, that go blind by approximately one month of age. In contrast, placing sighted animals in darkness significantly impairs HD cell tuning. We find that blind mice use olfactory cues to maintain stable HD tuning and that prior visual experience leads to refined HD cell tuning in blind rd1 adult mice compared to congenitally blind animals. Finally, in the absence of both visual and olfactory cues, the HD attractor network remains intact but the preferred firing direction of HD cells drifts over time. These findings demonstrate flexibility in how the brain uses diverse sensory information to generate a stable directional representation of space.

Suggested Citation

  • Kadjita Asumbisa & Adrien Peyrache & Stuart Trenholm, 2022. "Flexible cue anchoring strategies enable stable head direction coding in both sighted and blind animals," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33204-0
    DOI: 10.1038/s41467-022-33204-0
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    References listed on IDEAS

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    1. Guillaume Viejo & Adrien Peyrache, 2020. "Precise coupling of the thalamic head-direction system to hippocampal ripples," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    2. Torkel Hafting & Marianne Fyhn & Sturla Molden & May-Britt Moser & Edvard I. Moser, 2005. "Microstructure of a spatial map in the entorhinal cortex," Nature, Nature, vol. 436(7052), pages 801-806, August.
    3. N. Lessard & M. Paré & F. Lepore & M. Lassonde, 1998. "Early-blind human subjects localize sound sources better than sighted subjects," Nature, Nature, vol. 395(6699), pages 278-280, September.
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    Cited by:

    1. Usman Farooq & George Dragoi, 2024. "Experience of Euclidean geometry sculpts the development and dynamics of rodent hippocampal sequential cell assemblies," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    2. Kevin K. Sit & Michael J. Goard, 2023. "Coregistration of heading to visual cues in retrosplenial cortex," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Federica Sigismondi & Yangwen Xu & Mattia Silvestri & Roberto Bottini, 2024. "Altered grid-like coding in early blind people," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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