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A hierarchical active inference model of spatial alternation tasks and the hippocampal-prefrontal circuit

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Listed:
  • Toon Van de Maele

    (Ghent University - imec
    VERSES Research Lab)

  • Bart Dhoedt

    (Ghent University - imec)

  • Tim Verbelen

    (VERSES Research Lab)

  • Giovanni Pezzulo

    (National Research Council)

Abstract

Cognitive problem-solving benefits from cognitive maps aiding navigation and planning. Physical space navigation involves hippocampal (HC) allocentric codes, while abstract task space engages medial prefrontal cortex (mPFC) task-specific codes. Previous studies show that challenging tasks, like spatial alternation, require integrating these two types of maps. The disruption of the HC-mPFC circuit impairs performance. We propose a hierarchical active inference model clarifying how this circuit solves spatial interaction tasks by bridging physical and task-space maps. Simulations demonstrate that the model’s dual layers develop effective cognitive maps for physical and task space. The model solves spatial alternation tasks through reciprocal interactions between the two layers. Disrupting its communication impairs decision-making, which is consistent with empirical evidence. Additionally, the model adapts to switching between multiple alternation rules, providing a mechanistic explanation of how the HC-mPFC circuit supports spatial alternation tasks and the effects of disruption.

Suggested Citation

  • Toon Van de Maele & Bart Dhoedt & Tim Verbelen & Giovanni Pezzulo, 2024. "A hierarchical active inference model of spatial alternation tasks and the hippocampal-prefrontal circuit," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54257-3
    DOI: 10.1038/s41467-024-54257-3
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    References listed on IDEAS

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    1. Stefano Recanatesi & Matthew Farrell & Guillaume Lajoie & Sophie Deneve & Mattia Rigotti & Eric Shea-Brown, 2021. "Predictive learning as a network mechanism for extracting low-dimensional latent space representations," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Brad E. Pfeiffer & David J. Foster, 2013. "Hippocampal place-cell sequences depict future paths to remembered goals," Nature, Nature, vol. 497(7447), pages 74-79, May.
    3. Hiroshi T. Ito & Sheng-Jia Zhang & Menno P. Witter & Edvard I. Moser & May-Britt Moser, 2015. "A prefrontal–thalamo–hippocampal circuit for goal-directed spatial navigation," Nature, Nature, vol. 522(7554), pages 50-55, June.
    4. Dileep George & Rajeev V. Rikhye & Nishad Gothoskar & J. Swaroop Guntupalli & Antoine Dedieu & Miguel Lázaro-Gredilla, 2021. "Clone-structured graph representations enable flexible learning and vicarious evaluation of cognitive maps," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    5. Francesco Donnarumma & Domenico Maisto & Giovanni Pezzulo, 2016. "Problem Solving as Probabilistic Inference with Subgoaling: Explaining Human Successes and Pitfalls in the Tower of Hanoi," PLOS Computational Biology, Public Library of Science, vol. 12(4), pages 1-30, April.
    6. Raunak Basu & Robert Gebauer & Tim Herfurth & Simon Kolb & Zahra Golipour & Tatjana Tchumatchenko & Hiroshi T. Ito, 2021. "The orbitofrontal cortex maps future navigational goals," Nature, Nature, vol. 599(7885), pages 449-452, November.
    7. Torkel Hafting & Marianne Fyhn & Sturla Molden & May-Britt Moser & Edvard I. Moser, 2005. "Microstructure of a spatial map in the entorhinal cortex," Nature, Nature, vol. 436(7052), pages 801-806, August.
    8. Takuya Isomura & Kiyoshi Kotani & Yasuhiko Jimbo & Karl J. Friston, 2023. "Experimental validation of the free-energy principle with in vitro neural networks," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
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