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In situ analysis of nanoparticle soft corona and dynamic evolution

Author

Listed:
  • Didar Baimanov

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Peking University
    University of Chinese Academy of Sciences)

  • Jing Wang

    (Peking University)

  • Jun Zhang

    (University of Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Ke Liu

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Yalin Cong

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Xiaomeng Shi

    (Peking University)

  • Xiaohui Zhang

    (Peking University)

  • Yufeng Li

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Xiumin Li

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Rongrong Qiao

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Yuliang Zhao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    GBA Research Innovation Institute for Nanotechnology
    Chinese Academy of Medical Sciences)

  • Yunlong Zhou

    (University of Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Oujiang Laboratory, Zhejiang Laboratory for Regenerative Medicine, Vision and Brain Health)

  • Liming Wang

    (Chinese Academy of Sciences
    Peking University
    University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Chunying Chen

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    GBA Research Innovation Institute for Nanotechnology
    Chinese Academy of Medical Sciences)

Abstract

How soft corona, the protein corona’s outer layer, contributes to biological identity of nanomaterials is largely because capturing protein composition of the soft corona in situ remains challenging. We herein develop an in situ Fishing method that can monitor the dynamic formation of protein corona on ultra-small chiral Cu2S nanoparticles (NPs) allowing us to directly separate and identify the corona protein composition. Our method detects spatiotemporal processes in the evolution of hard and soft coronas on chiral NPs, revealing subtle differences in NP − protein interactions even within several minutes. This study highlights the importance of in situ and dynamic analysis of soft/hard corona, provides insights into the role of soft corona in mediating biological responses of NPs, and offers a universal strategy to characterize soft corona to guide the rational design of biomedical nanomaterials.

Suggested Citation

  • Didar Baimanov & Jing Wang & Jun Zhang & Ke Liu & Yalin Cong & Xiaomeng Shi & Xiaohui Zhang & Yufeng Li & Xiumin Li & Rongrong Qiao & Yuliang Zhao & Yunlong Zhou & Liming Wang & Chunying Chen, 2022. "In situ analysis of nanoparticle soft corona and dynamic evolution," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33044-y
    DOI: 10.1038/s41467-022-33044-y
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    References listed on IDEAS

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    1. Hossein Mohammad-Beigi & Yuya Hayashi & Christina Moeslund Zeuthen & Hoda Eskandari & Carsten Scavenius & Kristian Juul-Madsen & Thomas Vorup-Jensen & Jan J. Enghild & Duncan S. Sutherland, 2020. "Mapping and identification of soft corona proteins at nanoparticles and their impact on cellular association," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    2. Maozhong Sun & Liguang Xu & Joong Hwan Bahng & Hua Kuang & Silas Alben & Nicholas A. Kotov & Chuanlai Xu, 2017. "Intracellular localization of nanoparticle dimers by chirality reversal," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    3. Sara Sheibani & Kaustuv Basu & Ali Farnudi & Aliakbar Ashkarran & Muneyoshi Ichikawa & John F. Presley & Khanh Huy Bui & Mohammad Reza Ejtehadi & Hojatollah Vali & Morteza Mahmoudi, 2021. "Nanoscale characterization of the biomolecular corona by cryo-electron microscopy, cryo-electron tomography, and image simulation," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    4. Ke Hou & Jing Zhao & Hui Wang & Bin Li & Kexin Li & Xinghua Shi & Kaiwei Wan & Jing Ai & Jiawei Lv & Dawei Wang & Qunxing Huang & Huayi Wang & Qin Cao & Shaoqin Liu & Zhiyong Tang, 2020. "Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    5. Rui Shi & Chao Shan & Xiaomin Duan & Zhihai Chen & Peipei Liu & Jinwen Song & Tao Song & Xiaoshan Bi & Chao Han & Lianao Wu & Ge Gao & Xue Hu & Yanan Zhang & Zhou Tong & Weijin Huang & William Jun Liu, 2020. "A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2," Nature, Nature, vol. 584(7819), pages 120-124, August.
    6. Michael P. Vincent & Sharan Bobbala & Nicholas B. Karabin & Molly Frey & Yugang Liu & Justin O. Navidzadeh & Trevor Stack & Evan A. Scott, 2021. "Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
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    Cited by:

    1. Wei Jiang & Qing Li & Ruofei Zhang & Jianru Li & Qianyu Lin & Jingyun Li & Xinyao Zhou & Xiyun Yan & Kelong Fan, 2023. "Chiral metal-organic frameworks incorporating nanozymes as neuroinflammation inhibitors for managing Parkinson’s disease," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Yunqiu Miao & Lijun Li & Ying Wang & Jiangyue Wang & Yihan Zhou & Linmiao Guo & Yanqi Zhao & Di Nie & Yang Zhang & Xinxin Zhang & Yong Gan, 2024. "Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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