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In situ analysis of nanoparticle soft corona and dynamic evolution

Author

Listed:
  • Didar Baimanov

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Peking University
    University of Chinese Academy of Sciences)

  • Jing Wang

    (Peking University)

  • Jun Zhang

    (University of Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Ke Liu

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Yalin Cong

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Xiaomeng Shi

    (Peking University)

  • Xiaohui Zhang

    (Peking University)

  • Yufeng Li

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Xiumin Li

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Rongrong Qiao

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Yuliang Zhao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    GBA Research Innovation Institute for Nanotechnology
    Chinese Academy of Medical Sciences)

  • Yunlong Zhou

    (University of Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Oujiang Laboratory, Zhejiang Laboratory for Regenerative Medicine, Vision and Brain Health)

  • Liming Wang

    (Chinese Academy of Sciences
    Peking University
    University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Chunying Chen

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    GBA Research Innovation Institute for Nanotechnology
    Chinese Academy of Medical Sciences)

Abstract

How soft corona, the protein corona’s outer layer, contributes to biological identity of nanomaterials is largely because capturing protein composition of the soft corona in situ remains challenging. We herein develop an in situ Fishing method that can monitor the dynamic formation of protein corona on ultra-small chiral Cu2S nanoparticles (NPs) allowing us to directly separate and identify the corona protein composition. Our method detects spatiotemporal processes in the evolution of hard and soft coronas on chiral NPs, revealing subtle differences in NP − protein interactions even within several minutes. This study highlights the importance of in situ and dynamic analysis of soft/hard corona, provides insights into the role of soft corona in mediating biological responses of NPs, and offers a universal strategy to characterize soft corona to guide the rational design of biomedical nanomaterials.

Suggested Citation

  • Didar Baimanov & Jing Wang & Jun Zhang & Ke Liu & Yalin Cong & Xiaomeng Shi & Xiaohui Zhang & Yufeng Li & Xiumin Li & Rongrong Qiao & Yuliang Zhao & Yunlong Zhou & Liming Wang & Chunying Chen, 2022. "In situ analysis of nanoparticle soft corona and dynamic evolution," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33044-y
    DOI: 10.1038/s41467-022-33044-y
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    References listed on IDEAS

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    Cited by:

    1. Wei Jiang & Qing Li & Ruofei Zhang & Jianru Li & Qianyu Lin & Jingyun Li & Xinyao Zhou & Xiyun Yan & Kelong Fan, 2023. "Chiral metal-organic frameworks incorporating nanozymes as neuroinflammation inhibitors for managing Parkinson’s disease," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Yunqiu Miao & Lijun Li & Ying Wang & Jiangyue Wang & Yihan Zhou & Linmiao Guo & Yanqi Zhao & Di Nie & Yang Zhang & Xinxin Zhang & Yong Gan, 2024. "Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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