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Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery

Author

Listed:
  • Yunqiu Miao

    (Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Tongji University)

  • Lijun Li

    (Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Ying Wang

    (Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jiangyue Wang

    (Shanghai Institute of Materia Medica, Chinese Academy of Sciences)

  • Yihan Zhou

    (Shanghai Institute of Materia Medica, Chinese Academy of Sciences)

  • Linmiao Guo

    (Shanghai Institute of Materia Medica, Chinese Academy of Sciences)

  • Yanqi Zhao

    (Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Di Nie

    (Shanghai Institute of Materia Medica, Chinese Academy of Sciences)

  • Yang Zhang

    (Tongji University)

  • Xinxin Zhang

    (Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Bohai Rim Advanced Research Institute for Drug Discovery)

  • Yong Gan

    (Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    National Institutes for Food and Drug Control)

Abstract

The dynamic protein corona formed on nanocarriers has been revealed to strongly affect their in vivo behaviors. Precisely manipulating the formation of protein corona on nanocarriers may provide an alternative impetus for specific drug delivery. Herein, we explore the role of glycosylated polyhydroxy polymer-modified nanovesicles (CP-LVs) with different amino/hydroxyl ratios in protein corona formation and evolution. CP-LVs with an amino/hydroxyl ratio of approximately 0.4 (CP1-LVs) are found to efficiently suppress immunoglobulin adsorption in blood and livers, resulting in prolonged circulation. Moreover, CP1-LVs adsorb abundant tumor distinctive proteins, such as CD44 and osteopontin in tumor interstitial fluids, mediating selective tumor cell internalization. The proteins corona transformation specific to the environment appears to be affected by the electrostatic interaction between CP-LVs and proteins with diverse isoelectric points. Benefiting from surface modification-mediated protein corona regulation, paclitaxel-loaded CP1-LVs demonstrate superior antitumor efficacy to PEGylated liposomes. Our work offers a perspective on rational surface-design of nanocarriers to modulate the protein corona formation for efficient drug delivery.

Suggested Citation

  • Yunqiu Miao & Lijun Li & Ying Wang & Jiangyue Wang & Yihan Zhou & Linmiao Guo & Yanqi Zhao & Di Nie & Yang Zhang & Xinxin Zhang & Yong Gan, 2024. "Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45254-7
    DOI: 10.1038/s41467-024-45254-7
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    References listed on IDEAS

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    1. Nicolas Bertrand & Philippe Grenier & Morteza Mahmoudi & Eliana M. Lima & Eric A. Appel & Flavio Dormont & Jong-Min Lim & Rohit Karnik & Robert Langer & Omid C. Farokhzad, 2017. "Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics," Nature Communications, Nature, vol. 8(1), pages 1-8, December.
    2. Dah-Jiun Fu & Lianghai Wang & Fouad K. Chouairi & Ian M. Rose & Danysh A. Abetov & Andrew D. Miller & Robert J. Yamulla & John C. Schimenti & Andrea Flesken-Nikitin & Alexander Yu. Nikitin, 2020. "Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
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