IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-26354-0.html
   My bibliography  Save this article

COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models

Author

Listed:
  • Pauline Maisonnasse

    (Fontenay-aux-Roses & Le Kremlin-Bicêtre)

  • Yoann Aldon

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Aurélien Marc

    (Université de Paris, INSERM, IAME)

  • Romain Marlin

    (Fontenay-aux-Roses & Le Kremlin-Bicêtre)

  • Nathalie Dereuddre-Bosquet

    (Fontenay-aux-Roses & Le Kremlin-Bicêtre)

  • Natalia A. Kuzmina

    (University of Texas Medical Branch at Galveston
    Galveston National Laboratory)

  • Alec W. Freyn

    (Department of Microbiology, Icahn School of Medicine at Mount Sinai)

  • Jonne L. Snitselaar

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Antonio Gonçalves

    (Université de Paris, INSERM, IAME)

  • Tom G. Caniels

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Judith A. Burger

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Meliawati Poniman

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Ilja Bontjer

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Virginie Chesnais

    (Life and Soft)

  • Ségolène Diry

    (Life and Soft)

  • Anton Iershov

    (Life and Soft)

  • Adam J. Ronk

    (University of Texas Medical Branch at Galveston
    Galveston National Laboratory)

  • Sonia Jangra

    (Department of Microbiology, Icahn School of Medicine at Mount Sinai)

  • Raveen Rathnasinghe

    (Department of Microbiology, Icahn School of Medicine at Mount Sinai
    Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai)

  • Philip J. M. Brouwer

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Tom P. L. Bijl

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Jelle Schooten

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Mitch Brinkkemper

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Hejun Liu

    (Department of Integrative Structural and Computational Biology, The Scripps Research Institute)

  • Meng Yuan

    (Department of Integrative Structural and Computational Biology, The Scripps Research Institute)

  • Chad E. Mire

    (Galveston National Laboratory
    University of Texas Medical Branch at Galveston)

  • Mariëlle J. Breemen

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Vanessa Contreras

    (Fontenay-aux-Roses & Le Kremlin-Bicêtre)

  • Thibaut Naninck

    (Fontenay-aux-Roses & Le Kremlin-Bicêtre)

  • Julien Lemaître

    (Fontenay-aux-Roses & Le Kremlin-Bicêtre)

  • Nidhal Kahlaoui

    (Fontenay-aux-Roses & Le Kremlin-Bicêtre)

  • Francis Relouzat

    (Fontenay-aux-Roses & Le Kremlin-Bicêtre)

  • Catherine Chapon

    (Fontenay-aux-Roses & Le Kremlin-Bicêtre)

  • Raphaël Ho Tsong Fang

    (Fontenay-aux-Roses & Le Kremlin-Bicêtre)

  • Charlene McDanal

    (Duke Human Vaccine Institute & Department of Surgery)

  • Mary Osei-Twum

    (Nexelis, Laval)

  • Natalie St-Amant

    (Nexelis, Laval)

  • Luc Gagnon

    (Nexelis, Laval)

  • David C. Montefiori

    (Duke Human Vaccine Institute & Department of Surgery)

  • Ian A. Wilson

    (Department of Integrative Structural and Computational Biology, The Scripps Research Institute)

  • Eric Ginoux

    (Life and Soft)

  • Godelieve J. Bree

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Adolfo García-Sastre

    (Department of Microbiology, Icahn School of Medicine at Mount Sinai
    Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai
    The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
    Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai)

  • Michael Schotsaert

    (Department of Microbiology, Icahn School of Medicine at Mount Sinai
    Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai)

  • Lynda Coughlan

    (Department of Microbiology, Icahn School of Medicine at Mount Sinai
    University of Maryland School of Medicine, Department of Microbiology and Immunology and Center for Vaccine Development and Global Health (CVD))

  • Alexander Bukreyev

    (University of Texas Medical Branch at Galveston
    Galveston National Laboratory
    University of Texas Medical Branch at Galveston)

  • Sylvie Werf

    (Université de Paris
    National Reference Center for Respiratory Viruses, Institut Pasteur)

  • Jérémie Guedj

    (Université de Paris, INSERM, IAME)

  • Rogier W. Sanders

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity
    Weill Medical College of Cornell University)

  • Marit J. Gils

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Roger Le Grand

    (Fontenay-aux-Roses & Le Kremlin-Bicêtre)

Abstract

Effective treatments against Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) are urgently needed. Monoclonal antibodies have shown promising results in patients. Here, we evaluate the in vivo prophylactic and therapeutic effect of COVA1-18, a neutralizing antibody highly potent against the B.1.1.7 isolate. In both prophylactic and therapeutic settings, SARS-CoV-2 remains undetectable in the lungs of treated hACE2 mice. Therapeutic treatment also causes a reduction in viral loads in the lungs of Syrian hamsters. When administered at 10 mg kg-1 one day prior to a high dose SARS-CoV-2 challenge in cynomolgus macaques, COVA1-18 shows very strong antiviral activity in the upper respiratory compartments. Using a mathematical model, we estimate that COVA1-18 reduces viral infectivity by more than 95% in these compartments, preventing lymphopenia and extensive lung lesions. Our findings demonstrate that COVA1-18 has a strong antiviral activity in three preclinical models and could be a valuable candidate for further clinical evaluation.

Suggested Citation

  • Pauline Maisonnasse & Yoann Aldon & Aurélien Marc & Romain Marlin & Nathalie Dereuddre-Bosquet & Natalia A. Kuzmina & Alec W. Freyn & Jonne L. Snitselaar & Antonio Gonçalves & Tom G. Caniels & Judith , 2021. "COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26354-0
    DOI: 10.1038/s41467-021-26354-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-26354-0
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-021-26354-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Roman Wölfel & Victor M. Corman & Wolfgang Guggemos & Michael Seilmaier & Sabine Zange & Marcel A. Müller & Daniela Niemeyer & Terry C. Jones & Patrick Vollmar & Camilla Rothe & Michael Hoelscher & To, 2020. "Author Correction: Virological assessment of hospitalized patients with COVID-2019," Nature, Nature, vol. 588(7839), pages 35-35, December.
    2. Pauline Maisonnasse & Jérémie Guedj & Vanessa Contreras & Sylvie Behillil & Caroline Solas & Romain Marlin & Thibaut Naninck & Andres Pizzorno & Julien Lemaitre & Antonio Gonçalves & Nidhal Kahlaoui &, 2020. "Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates," Nature, Nature, vol. 585(7826), pages 584-587, September.
    3. Seth J. Zost & Pavlo Gilchuk & James Brett Case & Elad Binshtein & Rita E. Chen & Joseph P. Nkolola & Alexandra Schäfer & Joseph X. Reidy & Andrew Trivette & Rachel S. Nargi & Rachel E. Sutton & Navee, 2020. "Potently neutralizing and protective human antibodies against SARS-CoV-2," Nature, Nature, vol. 584(7821), pages 443-449, August.
    4. Rui Shi & Chao Shan & Xiaomin Duan & Zhihai Chen & Peipei Liu & Jinwen Song & Tao Song & Xiaoshan Bi & Chao Han & Lianao Wu & Ge Gao & Xue Hu & Yanan Zhang & Zhou Tong & Weijin Huang & William Jun Liu, 2020. "A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2," Nature, Nature, vol. 584(7819), pages 120-124, August.
    5. Jessica A. Plante & Yang Liu & Jianying Liu & Hongjie Xia & Bryan A. Johnson & Kumari G. Lokugamage & Xianwen Zhang & Antonio E. Muruato & Jing Zou & Camila R. Fontes-Garfias & Divya Mirchandani & Dio, 2021. "Spike mutation D614G alters SARS-CoV-2 fitness," Nature, Nature, vol. 592(7852), pages 116-121, April.
    6. Pengfei Wang & Manoj S. Nair & Lihong Liu & Sho Iketani & Yang Luo & Yicheng Guo & Maple Wang & Jian Yu & Baoshan Zhang & Peter D. Kwong & Barney S. Graham & John R. Mascola & Jennifer Y. Chang & Mich, 2021. "Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7," Nature, Nature, vol. 593(7857), pages 130-135, May.
    7. Roman Wölfel & Victor M. Corman & Wolfgang Guggemos & Michael Seilmaier & Sabine Zange & Marcel A. Müller & Daniela Niemeyer & Terry C. Jones & Patrick Vollmar & Camilla Rothe & Michael Hoelscher & To, 2020. "Virological assessment of hospitalized patients with COVID-2019," Nature, Nature, vol. 581(7809), pages 465-469, May.
    8. Jessica A. Plante & Yang Liu & Jianying Liu & Hongjie Xia & Bryan A. Johnson & Kumari G. Lokugamage & Xianwen Zhang & Antonio E. Muruato & Jing Zou & Camila R. Fontes-Garfias & Divya Mirchandani & Dio, 2021. "Author Correction: Spike mutation D614G alters SARS-CoV-2 fitness," Nature, Nature, vol. 595(7865), pages 1-1, July.
    9. Shuang Wang & Yun Peng & Rongjuan Wang & Shasha Jiao & Min Wang & Weijin Huang & Chao Shan & Wen Jiang & Zepeng Li & Chunying Gu & Ben Chen & Xue Hu & Yanfeng Yao & Juan Min & Huajun Zhang & Ying Chen, 2020. "Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mathieu Claireaux & Tom G. Caniels & Marlon Gast & Julianna Han & Denise Guerra & Gius Kerster & Barbera D. C. Schaik & Aldo Jongejan & Angela I. Schriek & Marloes Grobben & Philip J. M. Brouwer & Kar, 2022. "A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Romain Marlin & Delphine Desjardins & Vanessa Contreras & Guillaume Lingas & Caroline Solas & Pierre Roques & Thibaut Naninck & Quentin Pascal & Sylvie Behillil & Pauline Maisonnasse & Julien Lemaitre, 2022. "Antiviral efficacy of favipiravir against Zika and SARS-CoV-2 viruses in non-human primates," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Tingting Li & Xiaojian Han & Chenjian Gu & Hangtian Guo & Huajun Zhang & Yingming Wang & Chao Hu & Kai Wang & Fengjiang Liu & Feiyang Luo & Yanan Zhang & Jie Hu & Wang Wang & Shenglong Li & Yanan Hao , 2021. "Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Monica Neagu & Carolina Constantin & Mihaela Surcel, 2021. "Testing Antigens, Antibodies, and Immune Cells in COVID-19 as a Public Health Topic—Experience and Outlines," IJERPH, MDPI, vol. 18(24), pages 1-16, December.
    3. Shanlin Ke & Scott T. Weiss & Yang-Yu Liu, 2022. "Dissecting the role of the human microbiome in COVID-19 via metagenome-assembled genomes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Tobias Schlager & Ashley V. Whillans, 2022. "People underestimate the probability of contracting the coronavirus from friends," Palgrave Communications, Palgrave Macmillan, vol. 9(1), pages 1-11, December.
    5. Chaitanya Kurhade & Jing Zou & Hongjie Xia & Hui Cai & Qi Yang & Mark Cutler & David Cooper & Alexander Muik & Kathrin U. Jansen & Xuping Xie & Kena A. Swanson & Pei‑Yong Shi, 2022. "Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine," Nature Communications, Nature, vol. 13(1), pages 1-4, December.
    6. Joseph Pateras & Preetam Ghosh, 2022. "A Computational Framework for Exploring SARS-CoV-2 Pharmacodynamic Dose and Timing Regimes," Mathematics, MDPI, vol. 10(20), pages 1-12, October.
    7. Li Wang & Markus H. Kainulainen & Nannan Jiang & Han Di & Gaston Bonenfant & Lisa Mills & Michael Currier & Punya Shrivastava-Ranjan & Brenda M. Calderon & Mili Sheth & Brian R. Mann & Jaber Hossain &, 2022. "Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    8. Marta Baselga & Juan J. Alba & Alberto J. Schuhmacher, 2022. "The Control of Metabolic CO 2 in Public Transport as a Strategy to Reduce the Transmission of Respiratory Infectious Diseases," IJERPH, MDPI, vol. 19(11), pages 1-19, May.
    9. Lisa Cariani & Beatrice Silvia Orena & Federico Ambrogi & Simone Gambazza & Anna Maraschini & Antonella Dodaro & Massimo Oggioni & Annarosa Orlandi & Alessia Pirrone & Sara Uceda Renteria & Mara Berna, 2020. "Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study," IJERPH, MDPI, vol. 17(15), pages 1-10, July.
    10. Dapeng Li & David R. Martinez & Alexandra Schäfer & Haiyan Chen & Maggie Barr & Laura L. Sutherland & Esther Lee & Robert Parks & Dieter Mielke & Whitney Edwards & Amanda Newman & Kevin W. Bock & Mahn, 2022. "Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    11. Lorenz Schubert & Robert Strassl & Heinz Burgmann & Gabriella Dvorak & Matthias Karer & Michael Kundi & Manuel Kussmann & Heimo Lagler & Felix Lötsch & Christopher Milacek & Markus Obermueller & Zoe O, 2021. "A Longitudinal Seroprevalence Study Evaluating Infection Control and Prevention Strategies at a Large Tertiary Care Center with Low COVID-19 Incidence," IJERPH, MDPI, vol. 18(8), pages 1-10, April.
    12. Susanna Esposito & Federico Marchetti & Marcello Lanari & Fabio Caramelli & Alessandro De Fanti & Gianluca Vergine & Lorenzo Iughetti & Martina Fornaro & Agnese Suppiej & Stefano Zona & Andrea Pession, 2021. "COVID-19 Management in the Pediatric Age: Consensus Document of the COVID-19 Working Group in Paediatrics of the Emilia-Romagna Region (RE-CO-Ped), Italy," IJERPH, MDPI, vol. 18(8), pages 1-29, April.
    13. Ramon Roozendaal & Laura Solforosi & Daniel J. Stieh & Jan Serroyen & Roel Straetemans & Anna Dari & Muriel Boulton & Frank Wegmann & Sietske K. Rosendahl Huber & Joan E. M. van der Lubbe & Jenny Hend, 2021. "SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    14. Shengwei Zhu & Tong Lin & John D. Spengler & Jose Guillermo Cedeño Laurent & Jelena Srebric, 2022. "The Influence of Plastic Barriers on Aerosol Infection Risk during Airport Security Checks," Sustainability, MDPI, vol. 14(18), pages 1-14, September.
    15. Sasha Harris-Lovett & Kara L. Nelson & Paloma Beamer & Heather N. Bischel & Aaron Bivins & Andrea Bruder & Caitlyn Butler & Todd D. Camenisch & Susan K. De Long & Smruthi Karthikeyan & David A. Larsen, 2021. "Wastewater Surveillance for SARS-CoV-2 on College Campuses: Initial Efforts, Lessons Learned, and Research Needs," IJERPH, MDPI, vol. 18(9), pages 1-20, April.
    16. Elizabeth M. Parzych & Jianqiu Du & Ali R. Ali & Katherine Schultheis & Drew Frase & Trevor R. F. Smith & Jiayan Cui & Neethu Chokkalingam & Nicholas J. Tursi & Viviane M. Andrade & Bryce M. Warner & , 2022. "DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    17. Juan Liu & Fengfeng Mao & Jianhe Chen & Shuaiyao Lu & Yonghe Qi & Yinyan Sun & Linqiang Fang & Man Lung Yeung & Chunmei Liu & Guimei Yu & Guangyu Li & Ximing Liu & Yuansheng Yao & Panpan Huang & Dongx, 2023. "An IgM-like inhalable ACE2 fusion protein broadly neutralizes SARS-CoV-2 variants," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    18. Maria de Lourdes Aguiar-Oliveira & Aline Campos & Aline R. Matos & Caroline Rigotto & Adriana Sotero-Martins & Paulo F. P. Teixeira & Marilda M. Siqueira, 2020. "Wastewater-Based Epidemiology (WBE) and Viral Detection in Polluted Surface Water: A Valuable Tool for COVID-19 Surveillance—A Brief Review," IJERPH, MDPI, vol. 17(24), pages 1-19, December.
    19. Kumawat, Nitesh & Rashid, Mubasher & Srivastava, Akriti & Tripathi, Jai Prakash, 2023. "Hysteresis and Hopf bifurcation: Deciphering the dynamics of an in-host model of SARS-CoV-2 with logistic target cell growth and sigmoidal immune response," Chaos, Solitons & Fractals, Elsevier, vol. 176(C).
    20. Nagel, Kai & Rakow, Christian & Müller, Sebastian A., 2021. "Realistic agent-based simulation of infection dynamics and percolation," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 584(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26354-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.