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Endosomal sorting results in a selective separation of the protein corona from nanoparticles

Author

Listed:
  • Shen Han

    (Max Planck Institute for Polymer Research)

  • Richard Costa Marques

    (Max Planck Institute for Polymer Research
    University Medical Center of the Johannes Gutenberg-University Mainz)

  • Johanna Simon

    (Max Planck Institute for Polymer Research
    University Medical Center of the Johannes Gutenberg-University Mainz)

  • Anke Kaltbeitzel

    (Max Planck Institute for Polymer Research)

  • Kaloian Koynov

    (Max Planck Institute for Polymer Research)

  • Katharina Landfester

    (Max Planck Institute for Polymer Research)

  • Volker Mailänder

    (Max Planck Institute for Polymer Research
    University Medical Center of the Johannes Gutenberg-University Mainz)

  • Ingo Lieberwirth

    (Max Planck Institute for Polymer Research)

Abstract

The formation of the protein corona is a well-known effect when nanoparticles (NP) are exposed to biological environments. The protein corona is the most important factor, which determines the rate and route of endocytosis, and decisively impacts cellular processes and even the release of the active pharmaceutical ingredient from the nanoparticles. While many studies concentrate on the effect of the protein corona formation extracellularly or the uptake consequences, little is known about the fate of the protein corona inside of cells. Here, we reconstruct for the first time the separation of the protein corona from the NPs by the cell and their further fate. Ultimately, the NPs and protein corona are separated from each other and end up in morphologically different cellular compartments. The cell directs the NPs towards recycling endosomes, whereas the protein corona gathers in multivesicular bodies. From this, we conclude that the NPs are prepared for subsequent exocytosis, while the protein corona remains in the cell and is finally metabolized there.

Suggested Citation

  • Shen Han & Richard Costa Marques & Johanna Simon & Anke Kaltbeitzel & Kaloian Koynov & Katharina Landfester & Volker Mailänder & Ingo Lieberwirth, 2023. "Endosomal sorting results in a selective separation of the protein corona from nanoparticles," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35902-9
    DOI: 10.1038/s41467-023-35902-9
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    References listed on IDEAS

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    1. Hossein Mohammad-Beigi & Yuya Hayashi & Christina Moeslund Zeuthen & Hoda Eskandari & Carsten Scavenius & Kristian Juul-Madsen & Thomas Vorup-Jensen & Jan J. Enghild & Duncan S. Sutherland, 2020. "Mapping and identification of soft corona proteins at nanoparticles and their impact on cellular association," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    2. Srinivas Abbina & Lily E. Takeuchi & Parambath Anilkumar & Kai Yu & Jason C. Rogalski & Rajesh A. Shenoi & Iren Constantinescu & Jayachandran N. Kizhakkedathu, 2020. "Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
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