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Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease

Author

Listed:
  • Ke Hou

    (CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
    Peking University
    University of Chinese Academy of Sciences)

  • Jing Zhao

    (MOE Key Laboratory of Micro-systems and Micro-structures Manufacturing, School of Life Science and Technology, Harbin Institute of Technology)

  • Hui Wang

    (CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology)

  • Bin Li

    (CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
    School of Chemical Engineering and Technology, Sun Yat-sen University)

  • Kexin Li

    (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, College of Pharmacy of Harbin Medical University)

  • Xinghua Shi

    (CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology)

  • Kaiwei Wan

    (CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology)

  • Jing Ai

    (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, College of Pharmacy of Harbin Medical University)

  • Jiawei Lv

    (CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology)

  • Dawei Wang

    (CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology)

  • Qunxing Huang

    (CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology)

  • Huayi Wang

    (CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology)

  • Qin Cao

    (UCLA-DOE Institute and Howard Hughes Medical Institute, UCLA)

  • Shaoqin Liu

    (MOE Key Laboratory of Micro-systems and Micro-structures Manufacturing, School of Life Science and Technology, Harbin Institute of Technology)

  • Zhiyong Tang

    (CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

Abstract

Preventing aggregation of amyloid beta (Aβ) peptides is a promising strategy for the treatment of Alzheimer’s disease (AD), and gold nanoparticles have previously been explored as a potential anti-Aβ therapeutics. Here we design and prepare 3.3 nm L- and D-glutathione stabilized gold nanoparticles (denoted as L3.3 and D3.3, respectively). Both chiral nanoparticles are able to inhibit aggregation of Aβ42 and cross the blood-brain barrier (BBB) following intravenous administration without noticeable toxicity. D3.3 possesses a larger binding affinity to Aβ42 and higher brain biodistribution compared with its enantiomer L3.3, giving rise to stronger inhibition of Aβ42 fibrillation and better rescue of behavioral impairments in AD model mice. This conjugation of a small nanoparticle with chiral recognition moiety provides a potential therapeutic approach for AD.

Suggested Citation

  • Ke Hou & Jing Zhao & Hui Wang & Bin Li & Kexin Li & Xinghua Shi & Kaiwei Wan & Jing Ai & Jiawei Lv & Dawei Wang & Qunxing Huang & Huayi Wang & Qin Cao & Shaoqin Liu & Zhiyong Tang, 2020. "Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18525-2
    DOI: 10.1038/s41467-020-18525-2
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    Cited by:

    1. Didar Baimanov & Jing Wang & Jun Zhang & Ke Liu & Yalin Cong & Xiaomeng Shi & Xiaohui Zhang & Yufeng Li & Xiumin Li & Rongrong Qiao & Yuliang Zhao & Yunlong Zhou & Liming Wang & Chunying Chen, 2022. "In situ analysis of nanoparticle soft corona and dynamic evolution," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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