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Influence of the chirality of carbon nanodots on their interaction with proteins and cells

Author

Listed:
  • Huijie Yan

    (Universitat Hamburg)

  • Michele Cacioppo

    (Universitat Hamburg
    University of Trieste)

  • Saad Megahed

    (Universitat Hamburg
    Al-Azhar University)

  • Francesca Arcudi

    (University of Trieste)

  • Luka Đorđević

    (University of Trieste)

  • Dingcheng Zhu

    (Universitat Hamburg
    Hangzhou Normal University)

  • Florian Schulz

    (Universitat Hamburg)

  • Maurizio Prato

    (University of Trieste
    Basque Research and Technology Alliance (BRTA)
    Basque Foundation for Science, Ikerbasque)

  • Wolfgang J. Parak

    (Universitat Hamburg
    Basque Research and Technology Alliance (BRTA))

  • Neus Feliu

    (Universitat Hamburg
    Fraunhofer Center for Applied Nanotechnology (CAN))

Abstract

Carbon nanodots with opposite chirality possess the same major physicochemical properties such as optical features, hydrodynamic diameter, and colloidal stability. Here, a detailed analysis about the comparison of the concentration of both carbon nanodots is carried out, putting a threshold to when differences in biological behavior may be related to chirality and may exclude effects based merely on differences in exposure concentrations due to uncertainties in concentration determination. The present study approaches this comparative analysis evaluating two basic biological phenomena, the protein adsorption and cell internalization. We find how a meticulous concentration error estimation enables the evaluation of the differences in biological effects related to chirality.

Suggested Citation

  • Huijie Yan & Michele Cacioppo & Saad Megahed & Francesca Arcudi & Luka Đorđević & Dingcheng Zhu & Florian Schulz & Maurizio Prato & Wolfgang J. Parak & Neus Feliu, 2021. "Influence of the chirality of carbon nanodots on their interaction with proteins and cells," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27406-1
    DOI: 10.1038/s41467-021-27406-1
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    References listed on IDEAS

    as
    1. Maozhong Sun & Liguang Xu & Joong Hwan Bahng & Hua Kuang & Silas Alben & Nicholas A. Kotov & Chuanlai Xu, 2017. "Intracellular localization of nanoparticle dimers by chirality reversal," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    2. Monica Carril & Daniel Padro & Pablo del Pino & Carolina Carrillo-Carrion & Marta Gallego & Wolfgang J. Parak, 2017. "In situ detection of the protein corona in complex environments," Nature Communications, Nature, vol. 8(1), pages 1-5, December.
    3. Yinhai Wang & Craig Ledgerwood & Claire Grills & Denise C Fitzgerald & Peter W Hamilton, 2012. "A Robust Co-Localisation Measurement Utilising Z-Stack Image Intensity Similarities for Biological Studies," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-15, February.
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