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A synaptic signal for novelty processing in the hippocampus

Author

Listed:
  • Ruy Gómez-Ocádiz

    (Université Paris Cité, Neural Circuits for Spatial Navigation and Memory, Department of Neuroscience
    Sorbonne Université, Collège Doctoral
    Karolinska Institutet)

  • Massimiliano Trippa

    (Sorbonne Université, Université Paris Cité)

  • Chun-Lei Zhang

    (Université Paris Cité, Neural Circuits for Spatial Navigation and Memory, Department of Neuroscience)

  • Lorenzo Posani

    (Université Paris Cité, Neural Circuits for Spatial Navigation and Memory, Department of Neuroscience
    Columbia University)

  • Simona Cocco

    (Sorbonne Université, Université Paris Cité)

  • Rémi Monasson

    (Sorbonne Université, Université Paris Cité)

  • Christoph Schmidt-Hieber

    (Université Paris Cité, Neural Circuits for Spatial Navigation and Memory, Department of Neuroscience)

Abstract

Episodic memory formation and recall are complementary processes that rely on opposing neuronal computations in the hippocampus. How this conflict is resolved in hippocampal circuits is unclear. To address this question, we obtained in vivo whole-cell patch-clamp recordings from dentate gyrus granule cells in head-fixed mice trained to explore and distinguish between familiar and novel virtual environments. We find that granule cells consistently show a small transient depolarisation upon transition to a novel environment. This synaptic novelty signal is sensitive to local application of atropine, indicating that it depends on metabotropic acetylcholine receptors. A computational model suggests that the synaptic response to novelty may bias granule cell population activity, which can drive downstream attractor networks to a new state, favouring the switch from recall to new memory formation when faced with novelty. Such a novelty-driven switch may enable flexible encoding of new memories while preserving stable retrieval of familiar ones.

Suggested Citation

  • Ruy Gómez-Ocádiz & Massimiliano Trippa & Chun-Lei Zhang & Lorenzo Posani & Simona Cocco & Rémi Monasson & Christoph Schmidt-Hieber, 2022. "A synaptic signal for novelty processing in the hippocampus," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31775-6
    DOI: 10.1038/s41467-022-31775-6
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    References listed on IDEAS

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