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Context value updating and multidimensional neuronal encoding in the retrosplenial cortex

Author

Listed:
  • Weilun Sun

    (Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE)
    Center for Behavioral Brain Sciences (CBBS))

  • Ilseob Choi

    (Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE)
    Center for Behavioral Brain Sciences (CBBS))

  • Stoyan Stoyanov

    (Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE))

  • Oleg Senkov

    (Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE))

  • Evgeni Ponimaskin

    (Hannover Medical School)

  • York Winter

    (Humboldt University)

  • Janelle M. P. Pakan

    (Center for Behavioral Brain Sciences (CBBS)
    Otto-von-Guericke University
    German Center for Neurodegenerative Diseases (DZNE))

  • Alexander Dityatev

    (Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE)
    Center for Behavioral Brain Sciences (CBBS)
    Otto-von-Guericke University)

Abstract

The retrosplenial cortex (RSC) has diverse functional inputs and is engaged by various sensory, spatial, and associative learning tasks. We examine how multiple functional aspects are integrated on the single-cell level in the RSC and how the encoding of task-related parameters changes across learning. Using a visuospatial context discrimination paradigm and two-photon calcium imaging in behaving mice, a large proportion of dysgranular RSC neurons was found to encode multiple task-related dimensions while forming context-value associations across learning. During reversal learning requiring increased cognitive flexibility, we revealed an increased proportion of multidimensional encoding neurons that showed higher decoding accuracy for behaviorally relevant context-value associations. Chemogenetic inactivation of RSC led to decreased behavioral context discrimination during learning phases in which context-value associations were formed, while recall of previously formed associations remained intact. RSC inactivation resulted in a persistent positive behavioral bias in valuing contexts, indicating a role for the RSC in context-value updating.

Suggested Citation

  • Weilun Sun & Ilseob Choi & Stoyan Stoyanov & Oleg Senkov & Evgeni Ponimaskin & York Winter & Janelle M. P. Pakan & Alexander Dityatev, 2021. "Context value updating and multidimensional neuronal encoding in the retrosplenial cortex," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26301-z
    DOI: 10.1038/s41467-021-26301-z
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    References listed on IDEAS

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    Cited by:

    1. Luis M. Franco & Michael J. Goard, 2024. "Differential stability of task variable representations in retrosplenial cortex," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Kyerl Park & Yoonsoo Yeo & Kisung Shin & Jeehyun Kwag, 2024. "Egocentric neural representation of geometric vertex in the retrosplenial cortex," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Oliver Barnstedt & Petra Mocellin & Stefan Remy, 2024. "A hippocampus-accumbens code guides goal-directed appetitive behavior," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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