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Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants

Author

Listed:
  • Milja Belik

    (Institute of Biomedicine, University of Turku)

  • Pinja Jalkanen

    (Institute of Biomedicine, University of Turku)

  • Rickard Lundberg

    (Institute of Biomedicine, University of Turku)

  • Arttu Reinholm

    (Institute of Biomedicine, University of Turku)

  • Larissa Laine

    (Finnish Institute for Health and Welfare)

  • Elina Väisänen

    (Institute of Biomedicine, University of Turku
    Finnish Institute for Health and Welfare)

  • Marika Skön

    (Finnish Institute for Health and Welfare)

  • Paula A. Tähtinen

    (Turku University Hospital and University of Turku)

  • Lauri Ivaska

    (Turku University Hospital and University of Turku)

  • Sari H. Pakkanen

    (Helsinki University Hospital and University of Helsinki)

  • Hanni K. Häkkinen

    (Helsinki University Hospital and University of Helsinki)

  • Eeva Ortamo

    (Helsinki University Hospital and University of Helsinki)

  • Arja Pasternack

    (University of Helsinki)

  • Mikael A. Ritvos

    (University of Helsinki)

  • Rauno A. Naves

    (University of Helsinki)

  • Simo Miettinen

    (University of Helsinki and HUSLAB)

  • Tarja Sironen

    (University of Helsinki and HUSLAB
    University of Helsinki)

  • Olli Vapalahti

    (University of Helsinki and HUSLAB
    University of Helsinki)

  • Olli Ritvos

    (University of Helsinki)

  • Pamela Österlund

    (Finnish Institute for Health and Welfare)

  • Anu Kantele

    (Helsinki University Hospital and University of Helsinki)

  • Johanna Lempainen

    (Institute of Biomedicine, University of Turku
    Turku University Hospital and University of Turku
    Clinical Microbiology, Turku University Hospital)

  • Laura Kakkola

    (Institute of Biomedicine, University of Turku)

  • Pekka Kolehmainen

    (Institute of Biomedicine, University of Turku)

  • Ilkka Julkunen

    (Institute of Biomedicine, University of Turku
    Clinical Microbiology, Turku University Hospital)

Abstract

Two COVID-19 mRNA (of BNT162b2, mRNA-1273) and two adenovirus vector vaccines (ChAdOx1 and Janssen) are licensed in Europe, but optimization of regime and dosing is still ongoing. Here we show in health care workers (n = 328) that two doses of BNT162b2, mRNA-1273, or a combination of ChAdOx1 adenovirus vector and mRNA vaccines administrated with a long 12-week dose interval induce equally high levels of anti-SARS-CoV-2 spike antibodies and neutralizing antibodies against D614 and Delta variant. By contrast, two doses of BNT162b2 with a short 3-week interval induce 2-3-fold lower titers of neutralizing antibodies than those from the 12-week interval, yet a third BNT162b2 or mRNA-1273 booster dose increases the antibody levels 4-fold compared to the levels after the second dose, as well as induces neutralizing antibody against Omicron BA.1 variant. Our data thus indicates that a third COVID-19 mRNA vaccine may induce cross-protective neutralizing antibodies against multiple variants.

Suggested Citation

  • Milja Belik & Pinja Jalkanen & Rickard Lundberg & Arttu Reinholm & Larissa Laine & Elina Väisänen & Marika Skön & Paula A. Tähtinen & Lauri Ivaska & Sari H. Pakkanen & Hanni K. Häkkinen & Eeva Ortamo , 2022. "Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30162-5
    DOI: 10.1038/s41467-022-30162-5
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    References listed on IDEAS

    as
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