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SARS-CoV-2 serosurvey across multiple waves of the COVID-19 pandemic in New York City between 2020–2023

Author

Listed:
  • Juan Manuel Carreño

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Abram L. Wagner

    (University of Michigan)

  • Brian Monahan

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Gagandeep Singh

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Daniel Floda

    (ISMMS)

  • Ana S. Gonzalez-Reiche

    (ISMMS)

  • Johnstone Tcheou

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Ariel Raskin

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Dominika Bielak

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Sara Morris

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Miriam Fried

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Temima Yellin

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Leeba Sullivan

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Emilia Mia Sordillo

    (Icahn School of Medicine at Mount Sinai)

  • Aubree Gordon

    (University of Michigan)

  • Harm Bakel

    (Icahn School of Medicine at Mount Sinai
    ISMMS
    ISMMS
    Icahn School of Medicine at Mount Sinai)

  • Viviana Simon

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Florian Krammer

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Medical University of Vienna)

Abstract

Sero-monitoring provides context to the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and changes in population immunity following vaccine introduction. Here, we describe results of a cross-sectional hospital-based study of anti-spike seroprevalence in New York City (NYC) from February 2020 to July 2022, and a follow-up period from August 2023 to October 2023. Samples from 55,092 individuals, spanning five epidemiological waves were analyzed. Prevalence ratios (PR) were obtained using Poisson regression. Anti-spike antibody levels increased gradually over the first two waves, with a sharp increase during the 3rd wave coinciding with SARS-CoV-2 vaccination in NYC resulting in seroprevalence levels >90% by July 2022. Our data provide insights into the dynamic changes in immunity occurring in a large and diverse metropolitan community faced with a new viral pathogen and reflects the patterns of antibody responses as the pandemic transitions into an endemic stage.

Suggested Citation

  • Juan Manuel Carreño & Abram L. Wagner & Brian Monahan & Gagandeep Singh & Daniel Floda & Ana S. Gonzalez-Reiche & Johnstone Tcheou & Ariel Raskin & Dominika Bielak & Sara Morris & Miriam Fried & Temim, 2024. "SARS-CoV-2 serosurvey across multiple waves of the COVID-19 pandemic in New York City between 2020–2023," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50052-2
    DOI: 10.1038/s41467-024-50052-2
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    References listed on IDEAS

    as
    1. Prabal K De, 2020. "Beyond race: Impacts of non-racial perceived discrimination on health access and outcomes in New York City," PLOS ONE, Public Library of Science, vol. 15(9), pages 1-13, September.
    2. Carolina Lucas & Chantal B. F. Vogels & Inci Yildirim & Jessica E. Rothman & Peiwen Lu & Valter Monteiro & Jeff R. Gehlhausen & Melissa Campbell & Julio Silva & Alexandra Tabachnikova & Mario A. Peña-, 2021. "Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity," Nature, Nature, vol. 600(7889), pages 523-529, December.
    3. Nina B Masters & Shu-Fang Shih & Allen Bukoff & Kaitlyn B Akel & Lindsay C Kobayashi & Alison L Miller & Harapan Harapan & Yihan Lu & Abram L Wagner, 2020. "Social distancing in response to the novel coronavirus (COVID-19) in the United States," PLOS ONE, Public Library of Science, vol. 15(9), pages 1-12, September.
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