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Comparative immunogenicity and reactogenicity of heterologous ChAdOx1-nCoV-19-priming and BNT162b2 or mRNA-1273-boosting with homologous COVID-19 vaccine regimens

Author

Listed:
  • Verena Klemis

    (Saarland University)

  • Tina Schmidt

    (Saarland University)

  • David Schub

    (Saarland University)

  • Janine Mihm

    (Saarland University
    SHG Kliniken)

  • Stefanie Marx

    (Saarland University)

  • Amina Abu-Omar

    (Saarland University)

  • Laura Ziegler

    (Saarland University)

  • Franziska Hielscher

    (Saarland University)

  • Candida Guckelmus

    (Saarland University)

  • Rebecca Urschel

    (Saarland University)

  • Stefan Wagenpfeil

    (Saarland University, Campus Homburg/Saar)

  • Sophie Schneitler

    (Saarland University)

  • Sören L. Becker

    (Saarland University)

  • Barbara C. Gärtner

    (Saarland University)

  • Urban Sester

    (Saarland University
    SHG Kliniken)

  • Martina Sester

    (Saarland University)

Abstract

Comparative analyses of the immunogenicity and reactogenicity of homologous and heterologous SARS-CoV-2 vaccine-regimens will inform optimized vaccine strategies. Here we analyze the humoral and cellular immune response following heterologous and homologous vaccination strategies in a convenience cohort of 331 healthy individuals. All regimens induce immunity to the vaccine antigen. Immunity after vaccination with ChAdOx1-nCoV-19 followed by either BNT162b2 (n = 66) or mRNA-1273 (n = 101) is equivalent to or more pronounced than homologous mRNA-regimens (n = 43 BNT162b2, n = 59 mRNA-1273) or homologous ChAdOx1-nCoV-19 vaccination (n = 62). We note highest levels of spike-specific CD8 T-cells following both heterologous regimens. Among mRNA-containing combinations, spike-specific CD4 T-cell levels in regimens including mRNA-1273 are higher than respective combinations with BNT162b2. Polyfunctional T-cell levels are highest in regimens based on ChAdOx1-nCoV-19-priming. All five regimens are well tolerated with most pronounced reactogenicity upon ChAdOx1-nCoV-19-priming, and ChAdOx1-nCoV-19/mRNA-1273-boosting. In conclusion, we present comparative analyses of immunogenicity and reactogenicity for heterologous vector/mRNA-boosting and homologous mRNA-regimens.

Suggested Citation

  • Verena Klemis & Tina Schmidt & David Schub & Janine Mihm & Stefanie Marx & Amina Abu-Omar & Laura Ziegler & Franziska Hielscher & Candida Guckelmus & Rebecca Urschel & Stefan Wagenpfeil & Sophie Schne, 2022. "Comparative immunogenicity and reactogenicity of heterologous ChAdOx1-nCoV-19-priming and BNT162b2 or mRNA-1273-boosting with homologous COVID-19 vaccine regimens," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32321-0
    DOI: 10.1038/s41467-022-32321-0
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    References listed on IDEAS

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    1. Bruno Pozzetto & Vincent Legros & Sophia Djebali & Véronique Barateau & Nicolas Guibert & Marine Villard & Loïc Peyrot & Omran Allatif & Jean-Baptiste Fassier & Amélie Massardier-Pilonchéry & Karen Br, 2021. "Immunogenicity and efficacy of heterologous ChAdOx1–BNT162b2 vaccination," Nature, Nature, vol. 600(7890), pages 701-706, December.
    2. Hayfield, Tristen & Racine, Jeffrey S., 2008. "Nonparametric Econometrics: The np Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 27(i05).
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    Cited by:

    1. Rebecca Urschel & Saskia Bronder & Verena Klemis & Stefanie Marx & Franziska Hielscher & Amina Abu-Omar & Candida Guckelmus & Sophie Schneitler & Christina Baum & Sören L. Becker & Barbara C. Gärtner , 2024. "SARS-CoV-2-specific cellular and humoral immunity after bivalent BA.4/5 COVID-19-vaccination in previously infected and non-infected individuals," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Eakachai Prompetchara & Chutitorn Ketloy & Mohamad-Gabriel Alameh & Kittipan Tharakhet & Papatsara Kaewpang & Nongnaphat Yostrerat & Patrawadee Pitakpolrat & Supranee Buranapraditkun & Suwimon Manopwi, 2023. "Immunogenicity and protective efficacy of SARS-CoV-2 mRNA vaccine encoding secreted non-stabilized spike in female mice," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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