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COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants

Author

Listed:
  • Pinja Jalkanen

    (University of Turku)

  • Pekka Kolehmainen

    (University of Turku)

  • Hanni K. Häkkinen

    (Helsinki University Hospital and University of Helsinki)

  • Moona Huttunen

    (University of Turku)

  • Paula A. Tähtinen

    (Turku University Hospital and University of Turku)

  • Rickard Lundberg

    (University of Turku)

  • Sari Maljanen

    (University of Turku)

  • Arttu Reinholm

    (University of Turku)

  • Sisko Tauriainen

    (University of Turku)

  • Sari H. Pakkanen

    (Helsinki University Hospital and University of Helsinki)

  • Iris Levonen

    (Helsinki University Hospital and University of Helsinki)

  • Arttu Nousiainen

    (Helsinki University Hospital and University of Helsinki)

  • Taru Miller

    (Helsinki University Hospital and University of Helsinki)

  • Hanna Välimaa

    (Helsinki University Hospital and University of Helsinki
    University of Helsinki)

  • Lauri Ivaska

    (Turku University Hospital and University of Turku)

  • Arja Pasternack

    (University of Helsinki)

  • Rauno Naves

    (University of Helsinki)

  • Olli Ritvos

    (University of Helsinki)

  • Pamela Österlund

    (Finnish Institute for Health and Welfare)

  • Suvi Kuivanen

    (University of Helsinki)

  • Teemu Smura

    (University of Helsinki)

  • Jussi Hepojoki

    (University of Helsinki)

  • Olli Vapalahti

    (University of Helsinki)

  • Johanna Lempainen

    (University of Turku
    Turku University Hospital and University of Turku)

  • Laura Kakkola

    (University of Turku)

  • Anu Kantele

    (Helsinki University Hospital and University of Helsinki)

  • Ilkka Julkunen

    (University of Turku
    Turku University Hospital)

Abstract

As SARS-CoV-2 has been circulating for over a year, dozens of vaccine candidates are under development or in clinical use. The BNT162b2 mRNA COVID-19 vaccine induces spike protein-specific neutralizing antibodies associated with protective immunity. The emergence of the B.1.1.7 and B.1.351 variants has raised concerns of reduced vaccine efficacy and increased re-infection rates. Here we show, that after the second dose, the sera of BNT162b2-vaccinated health care workers (n = 180) effectively neutralize the SARS-CoV-2 variant with the D614G substitution and the B.1.1.7 variant, whereas the neutralization of the B.1.351 variant is five-fold reduced. Despite the reduction, 92% of the seronegative vaccinees have a neutralization titre of >20 for the B.1.351 variant indicating some protection. The vaccinees’ neutralization titres exceeded those of recovered non-hospitalized COVID-19 patients. Our work provides evidence that the second dose of the BNT162b2 vaccine induces cross-neutralization of at least some of the circulating SARS-CoV-2 variants.

Suggested Citation

  • Pinja Jalkanen & Pekka Kolehmainen & Hanni K. Häkkinen & Moona Huttunen & Paula A. Tähtinen & Rickard Lundberg & Sari Maljanen & Arttu Reinholm & Sisko Tauriainen & Sari H. Pakkanen & Iris Levonen & A, 2021. "COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24285-4
    DOI: 10.1038/s41467-021-24285-4
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    Cited by:

    1. Milja Belik & Pinja Jalkanen & Rickard Lundberg & Arttu Reinholm & Larissa Laine & Elina Väisänen & Marika Skön & Paula A. Tähtinen & Lauri Ivaska & Sari H. Pakkanen & Hanni K. Häkkinen & Eeva Ortamo , 2022. "Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Nadège Nziza & Yixiang Deng & Lianna Wood & Navneet Dhanoa & Naomi Dulit-Greenberg & Tina Chen & Abigail S. Kane & Zoe Swank & Jameson P. Davis & Melina Demokritou & Anagha P. Chitnis & Alessio Fasano, 2024. "Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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