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Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

Author

Listed:
  • Irma Karabegović

    (Erasmus University Medical Center
    Erasmus University Medical Center
    National Health Laboratory)

  • Eliana Portilla-Fernandez

    (Erasmus University Medical Center)

  • Yang Li

    (Erasmus University Medical Center)

  • Jiantao Ma

    (Tufts University
    National Institutes of Health, Bethesda, Maryland and the Framingham Heart Study)

  • Silvana C. E. Maas

    (Erasmus University Medical Center
    Erasmus University Medical Center)

  • Daokun Sun

    (University of Texas Health Science Center at Houston)

  • Emily A. Hu

    (Johns Hopkins Bloomberg School of Public Health)

  • Brigitte Kühnel

    (German Research Center for Environmental Health
    German Research Center for Environmental Health)

  • Yan Zhang

    (German Cancer Research Center (DKFZ))

  • Srikant Ambatipudi

    (University of Bristol
    Sree Chitra Tirunal Institute for Medical Sciences and Technology
    International Agency for Research on Cancer (IARC))

  • Giovanni Fiorito

    (University of Sassari
    Imperial College London, Norfolk Place)

  • Jian Huang

    (Imperial College London, Norfolk Place
    UK Dementia Research Institute at Imperial College London
    Imperial College NIHR Biomedical Research Centre)

  • Juan E. Castillo-Fernandez

    (Kings College London
    Babraham Institute)

  • Kerri L. Wiggins

    (CHRU)

  • Niek Klein

    (University Medical Center Groningen, University of Groningen)

  • Sara Grioni

    (IRCCS National Cancer Institute Foundation)

  • Brenton R. Swenson

    (CHRU)

  • Silvia Polidoro

    (Imperial College London, Norfolk Place
    Italian Institute for Genomic Medicine (IIGM, former HuGeF), c/o IRCCS Candiolo)

  • Jorien L. Treur

    (Amsterdam UMC)

  • Cyrille Cuenin

    (International Agency for Research on Cancer (IARC))

  • Pei-Chien Tsai

    (Kings College London
    Chang Gung University
    Chang Gung Memorial Hospital)

  • Ricardo Costeira

    (Kings College London)

  • Veronique Chajes

    (International Agency for Research on Cancer)

  • Kim Braun

    (Erasmus University Medical Center)

  • Niek Verweij

    (University Medical Center Groningen, University of Groningen
    Genomics plc, Park End St)

  • Anja Kretschmer

    (German Research Center for Environmental Health
    German Research Center for Environmental Health)

  • Lude Franke

    (University Medical Center Groningen, University of Groningen
    Oncode Institute)

  • Joyce B. J. Meurs

    (Erasmus University Medical Center)

  • André G. Uitterlinden

    (Erasmus University Medical Center)

  • Robert J. Knegt

    (Erasmus University Medical Center)

  • M. Arfan Ikram

    (Erasmus University Medical Center)

  • Abbas Dehghan

    (Imperial College London, Norfolk Place
    UK Dementia Research Institute at Imperial College London)

  • Annette Peters

    (German Research Center for Environmental Health
    German Research Center for Environmental Health
    Partner Site Munich Heart Alliance)

  • Ben Schöttker

    (German Cancer Research Center (DKFZ))

  • Sina A. Gharib

    (University of Washington)

  • Nona Sotoodehnia

    (CHRU)

  • Jordana T. Bell

    (Kings College London)

  • Paul Elliott

    (Imperial College London, Norfolk Place
    UK Dementia Research Institute at Imperial College London
    Imperial College NIHR Biomedical Research Centre
    Health Data Research UK-London)

  • Paolo Vineis

    (Imperial College London, Norfolk Place)

  • Caroline Relton

    (University of Bristol)

  • Zdenko Herceg

    (International Agency for Research on Cancer (IARC))

  • Hermann Brenner

    (German Cancer Research Center (DKFZ)
    German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)
    German Cancer Research Center (DKFZ)
    University of Heidelberg)

  • Melanie Waldenberger

    (German Research Center for Environmental Health
    German Research Center for Environmental Health
    Partner Site Munich Heart Alliance)

  • Casey M. Rebholz

    (Johns Hopkins Bloomberg School of Public Health)

  • Trudy Voortman

    (Erasmus University Medical Center)

  • Qiuwei Pan

    (Erasmus University Medical Center)

  • Myriam Fornage

    (University of Texas Health Science Center at Houston)

  • Daniel Levy

    (National Institutes of Health, Bethesda, Maryland and the Framingham Heart Study)

  • Manfred Kayser

    (Erasmus University Medical Center)

  • Mohsen Ghanbari

    (Erasmus University Medical Center
    Mashhad University of Medical Sciences)

Abstract

Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. Here we report the results from epigenome-wide association studies (EWAS) on coffee and tea consumption in 15,789 participants of European and African-American ancestries from 15 cohorts. EWAS meta-analysis of coffee consumption reveals 11 CpGs surpassing the epigenome-wide significance threshold (P-value

Suggested Citation

  • Irma Karabegović & Eliana Portilla-Fernandez & Yang Li & Jiantao Ma & Silvana C. E. Maas & Daokun Sun & Emily A. Hu & Brigitte Kühnel & Yan Zhang & Srikant Ambatipudi & Giovanni Fiorito & Jian Huang &, 2021. "Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22752-6
    DOI: 10.1038/s41467-021-22752-6
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    Cited by:

    1. Adrienne Tin & Pascal Schlosser & Pamela R. Matias-Garcia & Chris H. L. Thio & Roby Joehanes & Hongbo Liu & Zhi Yu & Antoine Weihs & Anselm Hoppmann & Franziska Grundner-Culemann & Josine L. Min & Vic, 2021. "Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus," Nature Communications, Nature, vol. 12(1), pages 1-18, December.

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