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Roma Ethnicity and Sex-Specific Associations of Serum Uric Acid with Cardiometabolic and Hepatorenal Health Factors in Eastern Slovakian Population: The HepaMeta Study

Author

Listed:
  • Maria Pallayova

    (Department of Medical Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia)

  • Marek Brenisin

    (Department of Pathological Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia)

  • Alina Putrya

    (2nd Department of Cardiology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
    Institute of Cardiovascular Diseases, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia)

  • Martin Vrsko

    (Department of Internal Medicine, AGEL Hospital, Kosice-Saca, 04015 Kosice, Slovakia)

  • Sylvia Drazilova

    (2nd Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
    Louis Pasteur University Hospital, 04011 Kosice, Slovakia)

  • Martin Janicko

    (2nd Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
    Louis Pasteur University Hospital, 04011 Kosice, Slovakia)

  • Maria Marekova

    (Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia)

  • Daniel Pella

    (2nd Department of Cardiology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
    Institute of Cardiovascular Diseases, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia)

  • Andrea Madarasova Geckova

    (Department of Health Psychology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia)

  • Peter Urdzik

    (Louis Pasteur University Hospital, 04011 Kosice, Slovakia
    Department of Gynaecology and Obstetrics, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia)

  • Peter Jarcuska

    (2nd Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
    Louis Pasteur University Hospital, 04011 Kosice, Slovakia)

  • HepaMeta Team

    (HepaMeta Team members are listed in Appendix A .)

Abstract

Background: Health characteristics associated with uric acid (UA) in the Roma minority remain less well known. The study sought to determine the ethnicity- and sex-specific associations of serum UA with health factors in Eastern Slovakian Roma and non-Roma populations. Methods: Data from the comparative cross-sectional HepaMeta study conducted in Slovakia in 2011 were used. The study enrolled 452 Roma subjects (35.2% men) and 403 non-Roma individuals (45.9% men) aged 18–55 years. Results: All study parameters differed between the sexes in both the Roma and non-Roma participants ( p < 0.05). UA was related to sex with odds ratio for female sex 0.873, 95% CI 0.853–0.893 ( p < 0.0001) per 10-unit increase of UA. Average level of UA ± standard deviation was lower in Roma than in non-Roma (226.54 ± 79.8 vs. 259.11 ± 84.53 umol/L; p < 0.0001). The Roma population presented with greater levels of high-sensitivity C-reactive protein (hsCRP) (3.07 ± 4 mg/L vs. 1.98 ± 2.83 mg/L; p < 0.0001) and ferritin in Roma males (403.78 ± 391.84 vs. 302.67 ± 236.26 mg/L; p < 0.0001). Conclusions: Serum UA is sex- and ethnicity specific. Elevated levels of hsCRP and ferritin particularly in Roma males can reflect low-grade systemic inflammation and thus serve as a marker of an increased cardiovascular risk.

Suggested Citation

  • Maria Pallayova & Marek Brenisin & Alina Putrya & Martin Vrsko & Sylvia Drazilova & Martin Janicko & Maria Marekova & Daniel Pella & Andrea Madarasova Geckova & Peter Urdzik & Peter Jarcuska & HepaMet, 2020. "Roma Ethnicity and Sex-Specific Associations of Serum Uric Acid with Cardiometabolic and Hepatorenal Health Factors in Eastern Slovakian Population: The HepaMeta Study," IJERPH, MDPI, vol. 17(20), pages 1-15, October.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:20:p:7673-:d:432230
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    References listed on IDEAS

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    1. Kazi Mirajul Hoque & Eryn E. Dixon & Raychel M. Lewis & Jordyn Allan & Gregory D. Gamble & Amanda J. Phipps-Green & Victoria L. Halperin Kuhns & Anne M. Horne & Lisa K. Stamp & Tony R. Merriman & Nico, 2020. "The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
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