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Epigenome-wide association studies identify DNA methylation associated with kidney function

Author

Listed:
  • Audrey Y. Chu

    (The Population Sciences Branch, Division of Intramural Research, NHLBI, NIH
    NHLBI’s Framingham Heart Study)

  • Adrienne Tin

    (Johns Hopkins Bloomberg School of Public Health)

  • Pascal Schlosser

    (Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center—University of Freiburg)

  • Yi-An Ko

    (Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, University of Pennsylvania, Perelman School of Medicine)

  • Chengxiang Qiu

    (Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, University of Pennsylvania, Perelman School of Medicine)

  • Chen Yao

    (The Population Sciences Branch, Division of Intramural Research, NHLBI, NIH
    NHLBI’s Framingham Heart Study)

  • Roby Joehanes

    (The Population Sciences Branch, Division of Intramural Research, NHLBI, NIH
    NHLBI’s Framingham Heart Study
    Institute of Aging Research, Hebrew Senior Life
    Beth Israel Deaconess Medical Center and Harvard Medical School)

  • Morgan E. Grams

    (Johns Hopkins Bloomberg School of Public Health)

  • Liming Liang

    (Harvard University School of Public Health)

  • Caroline A. Gluck

    (Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, University of Pennsylvania, Perelman School of Medicine)

  • Chunyu Liu

    (The Population Sciences Branch, Division of Intramural Research, NHLBI, NIH
    NHLBI’s Framingham Heart Study)

  • Josef Coresh

    (Johns Hopkins Bloomberg School of Public Health)

  • Shih-Jen Hwang

    (The Population Sciences Branch, Division of Intramural Research, NHLBI, NIH
    NHLBI’s Framingham Heart Study)

  • Daniel Levy

    (The Population Sciences Branch, Division of Intramural Research, NHLBI, NIH
    NHLBI’s Framingham Heart Study)

  • Eric Boerwinkle

    (Human Genetics Center, University of Texas Health Science Center)

  • James S. Pankow

    (Division of Epidemiology & Community Health, School of Public Health, University of Minnesota)

  • Qiong Yang

    (NHLBI’s Framingham Heart Study
    Boston University School of Public Health)

  • Myriam Fornage

    (Human Genetics Center, University of Texas Health Science Center)

  • Caroline S. Fox

    (The Population Sciences Branch, Division of Intramural Research, NHLBI, NIH
    NHLBI’s Framingham Heart Study)

  • Katalin Susztak

    (Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, University of Pennsylvania, Perelman School of Medicine)

  • Anna Köttgen

    (Johns Hopkins Bloomberg School of Public Health
    Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center—University of Freiburg)

Abstract

Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham Heart Study participants to identify epigenetic signatures of kidney function. Of 19 CpG sites significantly associated (P

Suggested Citation

  • Audrey Y. Chu & Adrienne Tin & Pascal Schlosser & Yi-An Ko & Chengxiang Qiu & Chen Yao & Roby Joehanes & Morgan E. Grams & Liming Liang & Caroline A. Gluck & Chunyu Liu & Josef Coresh & Shih-Jen Hwang, 2017. "Epigenome-wide association studies identify DNA methylation associated with kidney function," Nature Communications, Nature, vol. 8(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01297-7
    DOI: 10.1038/s41467-017-01297-7
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    Citations

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    Cited by:

    1. Laura J. Smyth & Emma H. Dahlström & Anna Syreeni & Katie Kerr & Jill Kilner & Ross Doyle & Eoin Brennan & Viji Nair & Damian Fermin & Robert G. Nelson & Helen C. Looker & Christopher Wooster & Darrel, 2022. "Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Anna Ulrich & Yukyee Wu & Harmen Draisma & John Wharton & Emilia M. Swietlik & Inês Cebola & Eleni Vasilaki & Zhanna Balkhiyarova & Marjo-Riitta Jarvelin & Juha Auvinen & Karl-Heinz Herzig & J. Gerry , 2024. "Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Pascal Schlosser & Adrienne Tin & Pamela R. Matias-Garcia & Chris H. L. Thio & Roby Joehanes & Hongbo Liu & Antoine Weihs & Zhi Yu & Anselm Hoppmann & Franziska Grundner-Culemann & Josine L. Min & Ade, 2021. "Meta-analyses identify DNA methylation associated with kidney function and damage," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    4. Yu Yan & Hongbo Liu & Amin Abedini & Xin Sheng & Matthew Palmer & Hongzhe Li & Katalin Susztak, 2024. "Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    5. Kelly Yichen Li & Claudia Ha Ting Tam & Hongbo Liu & Samantha Day & Cadmon King Poo Lim & Wing Yee So & Chuiguo Huang & Guozhi Jiang & Mai Shi & Heung Man Lee & Hui-yao Lan & Cheuk-Chun Szeto & Robert, 2023. "DNA methylation markers for kidney function and progression of diabetic kidney disease," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    6. Adrienne Tin & Pascal Schlosser & Pamela R. Matias-Garcia & Chris H. L. Thio & Roby Joehanes & Hongbo Liu & Zhi Yu & Antoine Weihs & Anselm Hoppmann & Franziska Grundner-Culemann & Josine L. Min & Vic, 2021. "Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus," Nature Communications, Nature, vol. 12(1), pages 1-18, December.

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