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Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9

Author

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  • Brian J DeBosch

    (BJC Institute of Health, Washington University School of Medicine)

  • Oliver Kluth

    (German Institute of Human Nutrition Potsdam-Rehbruecke)

  • Hideji Fujiwara

    (BJC Institute of Health, Washington University School of Medicine)

  • Annette Schürmann

    (German Institute of Human Nutrition Potsdam-Rehbruecke)

  • Kelle Moley

    (BJC Institute of Health, Washington University School of Medicine)

Abstract

Excess circulating uric acid, a product of hepatic glycolysis and purine metabolism, often accompanies metabolic syndrome. However, whether hyperuricaemia contributes to the development of metabolic syndrome or is merely a by-product of other processes that cause this disorder has not been resolved. In addition, how uric acid is cleared from the circulation is incompletely understood. Here we present a genetic model of spontaneous, early-onset metabolic syndrome in mice lacking the enterocyte urate transporter Glut9 (encoded by the SLC2A9 gene). Glut9-deficient mice develop impaired enterocyte uric acid transport kinetics, hyperuricaemia, hyperuricosuria, spontaneous hypertension, dyslipidaemia and elevated body fat. Allopurinol, a xanthine oxidase inhibitor, can reverse the hypertension and hypercholesterolaemia. These data provide evidence that hyperuricaemia per se could have deleterious metabolic sequelae. Moreover, these findings suggest that enterocytes may regulate whole-body metabolism, and that enterocyte urate metabolism could potentially be targeted to modulate or prevent metabolic syndrome.

Suggested Citation

  • Brian J DeBosch & Oliver Kluth & Hideji Fujiwara & Annette Schürmann & Kelle Moley, 2014. "Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9," Nature Communications, Nature, vol. 5(1), pages 1-7, December.
  • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5642
    DOI: 10.1038/ncomms5642
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    Cited by:

    1. Adrienne Tin & Pascal Schlosser & Pamela R. Matias-Garcia & Chris H. L. Thio & Roby Joehanes & Hongbo Liu & Zhi Yu & Antoine Weihs & Anselm Hoppmann & Franziska Grundner-Culemann & Josine L. Min & Vic, 2021. "Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus," Nature Communications, Nature, vol. 12(1), pages 1-18, December.

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