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Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator

Author

Listed:
  • Juan Salazar

    (Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • Pablo Durán

    (Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • María P. Díaz

    (Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • Maricarmen Chacín

    (Centro de Investigaciones en Ciencias de la Vida, Universidad Simón Bolívar, Barranquilla 080002, Colombia
    Sociedad Internacional de Rejuvenecimiento Facial No Quirúrgico (SIRF), Barranquilla 080002, Colombia)

  • Raquel Santeliz

    (Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • Edgardo Mengual

    (Biological Research Institute “Doctors Orlando Castejon and Haydee V Castejon”, Faculty of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • Emma Gutiérrez

    (Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • Xavier León

    (Instituto Ecuatoriano de Seguridad Social, Cuenca 010101, Ecuador)

  • Andrea Díaz

    (Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • Marycarlota Bernal

    (Facultad de Ingenierias, Universidad Simón Bolívar, Cúcuta 540001, Colombia)

  • Daniel Escalona

    (Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • Luis Alberto Parra Hernández

    (Sociedad Internacional de Rejuvenecimiento Facial No Quirúrgico (SIRF), Barranquilla 080002, Colombia)

  • Valmore Bermúdez

    (Centro de Investigaciones en Ciencias de la Vida, Universidad Simón Bolívar, Barranquilla 080002, Colombia)

Abstract

The gut microbiota (GM) has been the subject of intense research in recent years. Therefore, numerous factors affecting its composition have been thoroughly examined, and with them, their function and role in the individual’s systems. The gut microbiota’s taxonomical composition dramatically impacts older adults’ health status. In this regard, it could either extend their life expectancy via the modulation of metabolic processes and the immune system or, in the case of dysbiosis, predispose them to age-related diseases, including bowel inflammatory and musculoskeletal diseases and metabolic and neurological disorders. In general, the microbiome of the elderly tends to present taxonomic and functional changes, which can function as a target to modulate the microbiota and improve the health of this population. The GM of centenarians is unique, with the faculty-promoting metabolic pathways capable of preventing and counteracting the different processes associated with age-related diseases. The molecular mechanisms by which the microbiota can exhibit anti-ageing properties are mainly based on anti-inflammatory and antioxidant actions. This review focuses on analysing the current knowledge of gut microbiota characteristics and modifiers, its relationship with ageing, and the GM-modulating approaches to increase life expectancy.

Suggested Citation

  • Juan Salazar & Pablo Durán & María P. Díaz & Maricarmen Chacín & Raquel Santeliz & Edgardo Mengual & Emma Gutiérrez & Xavier León & Andrea Díaz & Marycarlota Bernal & Daniel Escalona & Luis Alberto Pa, 2023. "Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator," IJERPH, MDPI, vol. 20(10), pages 1-24, May.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:10:p:5845-:d:1148835
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