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Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator

Author

Listed:
  • Juan Salazar

    (Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • Pablo Durán

    (Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • María P. Díaz

    (Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • Maricarmen Chacín

    (Centro de Investigaciones en Ciencias de la Vida, Universidad Simón Bolívar, Barranquilla 080002, Colombia
    Sociedad Internacional de Rejuvenecimiento Facial No Quirúrgico (SIRF), Barranquilla 080002, Colombia)

  • Raquel Santeliz

    (Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • Edgardo Mengual

    (Biological Research Institute “Doctors Orlando Castejon and Haydee V Castejon”, Faculty of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • Emma Gutiérrez

    (Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • Xavier León

    (Instituto Ecuatoriano de Seguridad Social, Cuenca 010101, Ecuador)

  • Andrea Díaz

    (Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • Marycarlota Bernal

    (Facultad de Ingenierias, Universidad Simón Bolívar, Cúcuta 540001, Colombia)

  • Daniel Escalona

    (Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4001, Venezuela)

  • Luis Alberto Parra Hernández

    (Sociedad Internacional de Rejuvenecimiento Facial No Quirúrgico (SIRF), Barranquilla 080002, Colombia)

  • Valmore Bermúdez

    (Centro de Investigaciones en Ciencias de la Vida, Universidad Simón Bolívar, Barranquilla 080002, Colombia)

Abstract

The gut microbiota (GM) has been the subject of intense research in recent years. Therefore, numerous factors affecting its composition have been thoroughly examined, and with them, their function and role in the individual’s systems. The gut microbiota’s taxonomical composition dramatically impacts older adults’ health status. In this regard, it could either extend their life expectancy via the modulation of metabolic processes and the immune system or, in the case of dysbiosis, predispose them to age-related diseases, including bowel inflammatory and musculoskeletal diseases and metabolic and neurological disorders. In general, the microbiome of the elderly tends to present taxonomic and functional changes, which can function as a target to modulate the microbiota and improve the health of this population. The GM of centenarians is unique, with the faculty-promoting metabolic pathways capable of preventing and counteracting the different processes associated with age-related diseases. The molecular mechanisms by which the microbiota can exhibit anti-ageing properties are mainly based on anti-inflammatory and antioxidant actions. This review focuses on analysing the current knowledge of gut microbiota characteristics and modifiers, its relationship with ageing, and the GM-modulating approaches to increase life expectancy.

Suggested Citation

  • Juan Salazar & Pablo Durán & María P. Díaz & Maricarmen Chacín & Raquel Santeliz & Edgardo Mengual & Emma Gutiérrez & Xavier León & Andrea Díaz & Marycarlota Bernal & Daniel Escalona & Luis Alberto Pa, 2023. "Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator," IJERPH, MDPI, vol. 20(10), pages 1-24, May.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:10:p:5845-:d:1148835
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    1. Dachuan Zhang & Grace Chen & Deepa Manwani & Arthur Mortha & Chunliang Xu & Jeremiah J. Faith & Robert D. Burk & Yuya Kunisaki & Jung-Eun Jang & Christoph Scheiermann & Miriam Merad & Paul S. Frenette, 2015. "Neutrophil ageing is regulated by the microbiome," Nature, Nature, vol. 525(7570), pages 528-532, September.
    2. Reiner Jumpertz Schwartzenberg & Jordan E. Bisanz & Svetlana Lyalina & Peter Spanogiannopoulos & Qi Yan Ang & Jingwei Cai & Sophia Dickmann & Marie Friedrich & Su-Yang Liu & Stephanie L. Collins & Dan, 2021. "Caloric restriction disrupts the microbiota and colonization resistance," Nature, Nature, vol. 595(7866), pages 272-277, July.
    3. Yuko Sato & Koji Atarashi & Damian R. Plichta & Yasumichi Arai & Satoshi Sasajima & Sean M. Kearney & Wataru Suda & Kozue Takeshita & Takahiro Sasaki & Shoki Okamoto & Ashwin N. Skelly & Yuki Okamura , 2021. "Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians," Nature, Nature, vol. 599(7885), pages 458-464, November.
    4. Shuo Han & Will Treuren & Curt R. Fischer & Bryan D. Merrill & Brian C. DeFelice & Juan M. Sanchez & Steven K. Higginbottom & Leah Guthrie & Lalla A. Fall & Dylan Dodd & Michael A. Fischbach & Justin , 2021. "A metabolomics pipeline for the mechanistic interrogation of the gut microbiome," Nature, Nature, vol. 595(7867), pages 415-420, July.
    5. Jonas Schluter & Jonathan U. Peled & Bradford P. Taylor & Kate A. Markey & Melody Smith & Ying Taur & Rene Niehus & Anna Staffas & Anqi Dai & Emily Fontana & Luigi A. Amoretti & Roberta J. Wright & Se, 2020. "The gut microbiota is associated with immune cell dynamics in humans," Nature, Nature, vol. 588(7837), pages 303-307, December.
    6. Tanya Yatsunenko & Federico E. Rey & Mark J. Manary & Indi Trehan & Maria Gloria Dominguez-Bello & Monica Contreras & Magda Magris & Glida Hidalgo & Robert N. Baldassano & Andrey P. Anokhin & Andrew C, 2012. "Human gut microbiome viewed across age and geography," Nature, Nature, vol. 486(7402), pages 222-227, June.
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