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Rebuilding the Gut Microbiota Ecosystem

Author

Listed:
  • Antonella Gagliardi

    (Department of Public Health and Infectious Diseases, Section of Microbiology, Sapienza University of Rome, Rome 00185, Italy)

  • Valentina Totino

    (Department of Public Health and Infectious Diseases, Section of Microbiology, Sapienza University of Rome, Rome 00185, Italy)

  • Fatima Cacciotti

    (Department of Public Health and Infectious Diseases, Section of Microbiology, Sapienza University of Rome, Rome 00185, Italy)

  • Valerio Iebba

    (Department of Public Health and Infectious Diseases, Section of Microbiology, Sapienza University of Rome, Rome 00185, Italy)

  • Bruna Neroni

    (Department of Public Health and Infectious Diseases, Section of Microbiology, Sapienza University of Rome, Rome 00185, Italy)

  • Giulia Bonfiglio

    (Department of Public Health and Infectious Diseases, Section of Microbiology, Sapienza University of Rome, Rome 00185, Italy)

  • Maria Trancassini

    (Department of Public Health and Infectious Diseases, Section of Microbiology, Sapienza University of Rome, Rome 00185, Italy)

  • Claudio Passariello

    (Department of Public Health and Infectious Diseases, Section of Microbiology, Sapienza University of Rome, Rome 00185, Italy)

  • Fabrizio Pantanella

    (Department of Public Health and Infectious Diseases, Section of Microbiology, Sapienza University of Rome, Rome 00185, Italy)

  • Serena Schippa

    (Department of Public Health and Infectious Diseases, Section of Microbiology, Sapienza University of Rome, Rome 00185, Italy)

Abstract

A microbial ecosystem in which bacteria no longer live in a mutualistic association is called dysbiotic. Gut microbiota dysbiosis is a condition related with the pathogenesis of intestinal illnesses (irritable bowel syndrome, celiac disease, and inflammatory bowel disease) and extra-intestinal illnesses (obesity, metabolic disorder, cardiovascular syndrome, allergy, and asthma). Dysbiosis status has been related to various important pathologies, and many therapeutic strategies aimed at restoring the balance of the intestinal ecosystem have been implemented. These strategies include the administration of probiotics, prebiotics, and synbiotics; phage therapy; fecal transplantation; bacterial consortium transplantation; and a still poorly investigated approach based on predatory bacteria. This review discusses the various aspects of these strategies to counteract intestinal dysbiosis.

Suggested Citation

  • Antonella Gagliardi & Valentina Totino & Fatima Cacciotti & Valerio Iebba & Bruna Neroni & Giulia Bonfiglio & Maria Trancassini & Claudio Passariello & Fabrizio Pantanella & Serena Schippa, 2018. "Rebuilding the Gut Microbiota Ecosystem," IJERPH, MDPI, vol. 15(8), pages 1-24, August.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:8:p:1679-:d:162381
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    References listed on IDEAS

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    1. Nishant Gupta & Virendra Kumar Yadav & Amel Gacem & M. Al-Dossari & Krishna Kumar Yadav & N. S. Abd El-Gawaad & Nidhal Ben Khedher & Nisha Choudhary & Pankaj Kumar & Simona Cavalu, 2022. "Deleterious Effect of Air Pollution on Human Microbial Community and Bacterial Flora: A Short Review," IJERPH, MDPI, vol. 19(23), pages 1-16, November.

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