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Caloric restriction disrupts the microbiota and colonization resistance

Author

Listed:
  • Reiner Jumpertz Schwartzenberg

    (Charité Universitätsmedizin Berlin, Department of Endocrinology and Metabolic Diseases
    Berlin Institute of Health (BIH)
    partner site Berlin, Center for Cardiovascular Research (CCR))

  • Jordan E. Bisanz

    (University of California San Francisco)

  • Svetlana Lyalina

    (Gladstone Institutes)

  • Peter Spanogiannopoulos

    (University of California San Francisco)

  • Qi Yan Ang

    (University of California San Francisco)

  • Jingwei Cai

    (The Pennsylvania State University)

  • Sophia Dickmann

    (Charité Universitätsmedizin Berlin, Department of Endocrinology and Metabolic Diseases)

  • Marie Friedrich

    (Charité Universitätsmedizin Berlin, Department of Endocrinology and Metabolic Diseases)

  • Su-Yang Liu

    (University of California San Francisco)

  • Stephanie L. Collins

    (The Pennsylvania State University)

  • Danielle Ingebrigtsen

    (University of California San Francisco)

  • Steve Miller

    (University of California San Francisco)

  • Jessie A. Turnbaugh

    (University of California San Francisco)

  • Andrew D. Patterson

    (The Pennsylvania State University)

  • Katherine S. Pollard

    (Gladstone Institutes
    University of California San Francisco
    University of California San Francisco
    University of California San Francisco)

  • Knut Mai

    (Charité Universitätsmedizin Berlin, Department of Endocrinology and Metabolic Diseases
    Berlin Institute of Health (BIH))

  • Joachim Spranger

    (Charité Universitätsmedizin Berlin, Department of Endocrinology and Metabolic Diseases
    Berlin Institute of Health (BIH)
    partner site Berlin, Center for Cardiovascular Research (CCR))

  • Peter J. Turnbaugh

    (University of California San Francisco)

Abstract

Diet is a major factor that shapes the gut microbiome1, but the consequences of diet-induced changes in the microbiome for host pathophysiology remain poorly understood. We conducted a randomized human intervention study using a very-low-calorie diet (NCT01105143). Although metabolic health was improved, severe calorie restriction led to a decrease in bacterial abundance and restructuring of the gut microbiome. Transplantation of post-diet microbiota to mice decreased their body weight and adiposity relative to mice that received pre-diet microbiota. Weight loss was associated with impaired nutrient absorption and enrichment in Clostridioides difficile, which was consistent with a decrease in bile acids and was sufficient to replicate metabolic phenotypes in mice in a toxin-dependent manner. These results emphasize the importance of diet–microbiome interactions in modulating host energy balance and the need to understand the role of diet in the interplay between pathogenic and beneficial symbionts.

Suggested Citation

  • Reiner Jumpertz Schwartzenberg & Jordan E. Bisanz & Svetlana Lyalina & Peter Spanogiannopoulos & Qi Yan Ang & Jingwei Cai & Sophia Dickmann & Marie Friedrich & Su-Yang Liu & Stephanie L. Collins & Dan, 2021. "Caloric restriction disrupts the microbiota and colonization resistance," Nature, Nature, vol. 595(7866), pages 272-277, July.
  • Handle: RePEc:nat:nature:v:595:y:2021:i:7866:d:10.1038_s41586-021-03663-4
    DOI: 10.1038/s41586-021-03663-4
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    Cited by:

    1. Hagai Yanai & Bongsoo Park & Hyunwook Koh & Hyo Jung Jang & Kelli L. Vaughan & Mayuri Tanaka-Yano & Miguel Aon & Madison Blanton & Ilhem Messaoudi & Alberto Diaz-Ruiz & Julie A. Mattison & Isabel Beer, 2024. "Short-term periodic restricted feeding elicits metabolome-microbiome signatures with sex dimorphic persistence in primate intervention," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. K. E. Huus & T. T. Hoang & A. Creus-Cuadros & M. Cirstea & S. L. Vogt & K. Knuff-Janzen & P. J. Sansonetti & P. Vonaesch & B. B. Finlay, 2021. "Cross-feeding between intestinal pathobionts promotes their overgrowth during undernutrition," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    3. Alex E. Mohr & Karen L. Sweazea & Devin A. Bowes & Paniz Jasbi & Corrie M. Whisner & Dorothy D. Sears & Rosa Krajmalnik-Brown & Yan Jin & Haiwei Gu & Judith Klein-Seetharaman & Karen M. Arciero & Eric, 2024. "Gut microbiome remodeling and metabolomic profile improves in response to protein pacing with intermittent fasting versus continuous caloric restriction," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    4. Juan Salazar & Pablo Durán & María P. Díaz & Maricarmen Chacín & Raquel Santeliz & Edgardo Mengual & Emma Gutiérrez & Xavier León & Andrea Díaz & Marycarlota Bernal & Daniel Escalona & Luis Alberto Pa, 2023. "Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator," IJERPH, MDPI, vol. 20(10), pages 1-24, May.

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