IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v10y2013i12p7235-7256d31389.html
   My bibliography  Save this article

The Potential Link between Gut Microbiota and IgE-Mediated Food Allergy in Early Life

Author

Listed:
  • John Molloy

    (Child Health Research Unit, Barwon Health, Geelong, Victoria 3220, Australia
    School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia
    Murdoch Children's Research Institute, Parkville, Victoria 3052, Australia)

  • Katrina Allen

    (Murdoch Children's Research Institute, Parkville, Victoria 3052, Australia
    Department of Allergy and Immunology, Royal Children's Hospital, Parkville, Victoria 3052, Australia
    Department of Paediatrics, University of Melbourne, Parkville, Victoria 3052, Australia)

  • Fiona Collier

    (Child Health Research Unit, Barwon Health, Geelong, Victoria 3220, Australia
    School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia)

  • Mimi L. K. Tang

    (Murdoch Children's Research Institute, Parkville, Victoria 3052, Australia
    Department of Allergy and Immunology, Royal Children's Hospital, Parkville, Victoria 3052, Australia
    Department of Paediatrics, University of Melbourne, Parkville, Victoria 3052, Australia)

  • Alister C. Ward

    (School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia)

  • Peter Vuillermin

    (Child Health Research Unit, Barwon Health, Geelong, Victoria 3220, Australia
    School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia
    Murdoch Children's Research Institute, Parkville, Victoria 3052, Australia
    Department of Paediatrics, University of Melbourne, Parkville, Victoria 3052, Australia)

Abstract

There has been a dramatic rise in the prevalence of IgE-mediated food allergy over recent decades, particularly among infants and young children. The cause of this increase is unknown but one putative factor is a change in the composition, richness and balance of the microbiota that colonize the human gut during early infancy. The coevolution of the human gastrointestinal tract and commensal microbiota has resulted in a symbiotic relationship in which gut microbiota play a vital role in early life immune development and function, as well as maintenance of gut wall epithelial integrity. Since IgE mediated food allergy is associated with immune dysregulation and impaired gut epithelial integrity there is substantial interest in the potential link between gut microbiota and food allergy. Although the exact link between gut microbiota and food allergy is yet to be established in humans, recent experimental evidence suggests that specific patterns of gut microbiota colonization may influence the risk and manifestations of food allergy. An understanding of the relationship between gut microbiota and food allergy has the potential to inform both the prevention and treatment of food allergy. In this paper we review the theory and evidence linking gut microbiota and IgE-mediated food allergy in early life. We then consider the implications and challenges for future research, including the techniques of measuring and analyzing gut microbiota, and the types of studies required to advance knowledge in the field.

Suggested Citation

  • John Molloy & Katrina Allen & Fiona Collier & Mimi L. K. Tang & Alister C. Ward & Peter Vuillermin, 2013. "The Potential Link between Gut Microbiota and IgE-Mediated Food Allergy in Early Life," IJERPH, MDPI, vol. 10(12), pages 1-22, December.
    • Handle: RePEc:gam:jijerp:v:10:y:2013:i:12:p:7235-7256:d:31389
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/10/12/7235/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/10/12/7235/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Kendle M. Maslowski & Angelica T. Vieira & Aylwin Ng & Jan Kranich & Frederic Sierro & Di Yu & Heidi C. Schilter & Michael S. Rolph & Fabienne Mackay & David Artis & Ramnik J. Xavier & Mauro M. Teixei, 2009. "Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43," Nature, Nature, vol. 461(7268), pages 1282-1286, October.
    2. Peter J. Turnbaugh & Micah Hamady & Tanya Yatsunenko & Brandi L. Cantarel & Alexis Duncan & Ruth E. Ley & Mitchell L. Sogin & William J. Jones & Bruce A. Roe & Jason P. Affourtit & Michael Egholm & Be, 2009. "A core gut microbiome in obese and lean twins," Nature, Nature, vol. 457(7228), pages 480-484, January.
    3. Tanya Yatsunenko & Federico E. Rey & Mark J. Manary & Indi Trehan & Maria Gloria Dominguez-Bello & Monica Contreras & Magda Magris & Glida Hidalgo & Robert N. Baldassano & Andrey P. Anokhin & Andrew C, 2012. "Human gut microbiome viewed across age and geography," Nature, Nature, vol. 486(7402), pages 222-227, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Todd D. Terhune & Richard C. Deth, 2018. "Aluminum Adjuvant-Containing Vaccines in the Context of the Hygiene Hypothesis: A Risk Factor for Eosinophilia and Allergy in a Genetically Susceptible Subpopulation?," IJERPH, MDPI, vol. 15(5), pages 1-16, May.
    2. Lena Takayasu & Wataru Suda & Eiichiro Watanabe & Shinji Fukuda & Kageyasu Takanashi & Hiroshi Ohno & Misako Takayasu & Hideki Takayasu & Masahira Hattori, 2017. "A 3-dimensional mathematical model of microbial proliferation that generates the characteristic cumulative relative abundance distributions in gut microbiomes," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-20, August.
    3. Fiona B. Tamburini & Dylan Maghini & Ovokeraye H. Oduaran & Ryan Brewster & Michaella R. Hulley & Venesa Sahibdeen & Shane A. Norris & Stephen Tollman & Kathleen Kahn & Ryan G. Wagner & Alisha N. Wade, 2022. "Short- and long-read metagenomics of urban and rural South African gut microbiomes reveal a transitional composition and undescribed taxa," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    4. Doris Vandeputte & Lindsey Commer & Raul Y. Tito & Gunter Kathagen & João Sabino & Séverine Vermeire & Karoline Faust & Jeroen Raes, 2021. "Temporal variability in quantitative human gut microbiome profiles and implications for clinical research," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    5. Jeffrey D Galley & Michael Bailey & Claire Kamp Dush & Sarah Schoppe-Sullivan & Lisa M Christian, 2014. "Maternal Obesity Is Associated with Alterations in the Gut Microbiome in Toddlers," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-13, November.
    6. Gertrude Ecklu-Mensah & Candice Choo-Kang & Maria Gjerstad Maseng & Sonya Donato & Pascal Bovet & Bharathi Viswanathan & Kweku Bedu-Addo & Jacob Plange-Rhule & Prince Oti Boateng & Terrence E. Forrest, 2023. "Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: the METS-microbiome study," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    7. Silvia Rodrigues Jardim & Lucila Marieta Perrotta de Souza & Heitor Siffert Pereira de Souza, 2023. "The Rise of Gastrointestinal Cancers as a Global Phenomenon: Unhealthy Behavior or Progress?," IJERPH, MDPI, vol. 20(4), pages 1-23, February.
    8. Andrea Fontana & Concetta Panebianco & Andrea Picchianti-Diamanti & Bruno Laganà & Duccio Cavalieri & Adele Potenza & Riccardo Pracella & Elena Binda & Massimiliano Copetti & Valerio Pazienza, 2019. "Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study," IJERPH, MDPI, vol. 16(21), pages 1-20, October.
    9. Natalia Di Tommaso & Antonio Gasbarrini & Francesca Romana Ponziani, 2021. "Intestinal Barrier in Human Health and Disease," IJERPH, MDPI, vol. 18(23), pages 1-23, December.
    10. Allison G. White & George S. Watts & Zhenqiang Lu & Maria M. Meza-Montenegro & Eric A. Lutz & Philip Harber & Jefferey L. Burgess, 2014. "Environmental Arsenic Exposure and Microbiota in Induced Sputum," IJERPH, MDPI, vol. 11(2), pages 1-15, February.
    11. Eunkyung Lee & Vanessa Kady & Eric Han & Kayla Montan & Marjona Normuminova & Michael J. Rovito, 2022. "Healthy Eating and Mortality among Breast Cancer Survivors: A Systematic Review and Meta-Analysis of Cohort Studies," IJERPH, MDPI, vol. 19(13), pages 1-24, June.
    12. Pirjo Wacklin & Harri Mäkivuokko & Noora Alakulppi & Janne Nikkilä & Heli Tenkanen & Jarkko Räbinä & Jukka Partanen & Kari Aranko & Jaana Mättö, 2011. "Secretor Genotype (FUT2 gene) Is Strongly Associated with the Composition of Bifidobacteria in the Human Intestine," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-10, May.
    13. Agnieszka Mika & Will Van Treuren & Antonio González & Jonathan J Herrera & Rob Knight & Monika Fleshner, 2015. "Exercise Is More Effective at Altering Gut Microbial Composition and Producing Stable Changes in Lean Mass in Juvenile versus Adult Male F344 Rats," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-20, May.
    14. Sanjeena Subedi & Drew Neish & Stephen Bak & Zeny Feng, 2020. "Cluster analysis of microbiome data by using mixtures of Dirichlet–multinomial regression models," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 69(5), pages 1163-1187, November.
    15. Fanette Fontaine & Sondra Turjeman & Karel Callens & Omry Koren, 2023. "The intersection of undernutrition, microbiome, and child development in the first years of life," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    16. Shinji Fukuda & Yumiko Nakanishi & Eisuke Chikayama & Hiroshi Ohno & Tsuneo Hino & Jun Kikuchi, 2009. "Evaluation and Characterization of Bacterial Metabolic Dynamics with a Novel Profiling Technique, Real-Time Metabolotyping," PLOS ONE, Public Library of Science, vol. 4(3), pages 1-10, March.
    17. Davide Albanese & Carlotta De Filippo & Duccio Cavalieri & Claudio Donati, 2015. "Explaining Diversity in Metagenomic Datasets by Phylogenetic-Based Feature Weighting," PLOS Computational Biology, Public Library of Science, vol. 11(3), pages 1-18, March.
    18. Lai-yu Kwok & Jiachao Zhang & Zhuang Guo & Qimu Gesudu & Yi Zheng & Jianmin Qiao & Dongxue Huo & Heping Zhang, 2014. "Characterization of Fecal Microbiota across Seven Chinese Ethnic Groups by Quantitative Polymerase Chain Reaction," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-11, April.
    19. Paul J McMurdie & Susan Holmes, 2014. "Waste Not, Want Not: Why Rarefying Microbiome Data Is Inadmissible," PLOS Computational Biology, Public Library of Science, vol. 10(4), pages 1-12, April.
    20. Patricia L Hibberd & Lauren Kleimola & Anne-Maria Fiorino & Christine Botelho & Miriam Haverkamp & Irina Andreyeva & Debra Poutsiaka & Claire Fraser & Gloria Solano-Aguilar & David R Snydman, 2014. "No Evidence of Harms of Probiotic Lactobacillus rhamnosus GG ATCC 53103 in Healthy Elderly—A Phase I Open Label Study to Assess Safety, Tolerability and Cytokine Responses," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-21, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:10:y:2013:i:12:p:7235-7256:d:31389. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.