IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-37459-z.html
   My bibliography  Save this article

Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice

Author

Listed:
  • Qi Zhao

    (Sichuan University)

  • Man-Yun Dai

    (Sichuan University
    Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Ruo-Yue Huang

    (Sichuan University)

  • Jing-Yi Duan

    (Sichuan University)

  • Ting Zhang

    (Sichuan University
    Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Wei-Min Bao

    (The First People’s Hospital of Yunnan Province)

  • Jing-Yi Zhang

    (The second Affiliated Hospital of Kunming Medical University)

  • Shao-Qiang Gui

    (The second Affiliated Hospital of Kunming Medical University)

  • Shu-Min Xia

    (The second Affiliated Hospital of Kunming Medical University)

  • Cong-Ting Dai

    (The second Affiliated Hospital of Kunming Medical University)

  • Ying-Mei Tang

    (The second Affiliated Hospital of Kunming Medical University)

  • Frank J. Gonzalez

    (National Institutes of Health)

  • Fei Li

    (Sichuan University
    Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Center, West China Hospital, Sichuan University)

Abstract

Parabacteroides distasonis (P. distasonis) plays an important role in human health, including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that P. distasonis is decreased in patients with hepatic fibrosis, and that administration of P. distasonis to male mice improves thioacetamide (TAA)- and methionine and choline-deficient (MCD) diet-induced hepatic fibrosis. Administration of P. distasonis also leads to increased bile salt hydrolase (BSH) activity, inhibition of intestinal farnesoid X receptor (FXR) signaling and decreased taurochenodeoxycholic acid (TCDCA) levels in liver. TCDCA produces toxicity in mouse primary hepatic cells (HSCs) and induces mitochondrial permeability transition (MPT) and Caspase-11 pyroptosis in mice. The decrease of TCDCA by P. distasonis improves activation of HSCs through decreasing MPT-Caspase-11 pyroptosis in hepatocytes. Celastrol, a compound reported to increase P. distasonis abundance in mice, promotes the growth of P. distasonis with concomitant enhancement of bile acid excretion and improvement of hepatic fibrosis in male mice. These data suggest that supplementation of P. distasonis may be a promising means to ameliorate hepatic fibrosis.

Suggested Citation

  • Qi Zhao & Man-Yun Dai & Ruo-Yue Huang & Jing-Yi Duan & Ting Zhang & Wei-Min Bao & Jing-Yi Zhang & Shao-Qiang Gui & Shu-Min Xia & Cong-Ting Dai & Ying-Mei Tang & Frank J. Gonzalez & Fei Li, 2023. "Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37459-z
    DOI: 10.1038/s41467-023-37459-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-37459-z
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-023-37459-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Changtao Jiang & Cen Xie & Ying Lv & Jing Li & Kristopher W. Krausz & Jingmin Shi & Chad N. Brocker & Dhimant Desai & Shantu G. Amin & William H. Bisson & Yulan Liu & Oksana Gavrilova & Andrew D. Patt, 2015. "Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction," Nature Communications, Nature, vol. 6(1), pages 1-18, December.
    2. Shuo Han & Will Treuren & Curt R. Fischer & Bryan D. Merrill & Brian C. DeFelice & Juan M. Sanchez & Steven K. Higginbottom & Leah Guthrie & Lalla A. Fall & Dylan Dodd & Michael A. Fischbach & Justin , 2021. "A metabolomics pipeline for the mechanistic interrogation of the gut microbiome," Nature, Nature, vol. 595(7867), pages 415-420, July.
    3. Fei Li & Changtao Jiang & Kristopher W. Krausz & Yunfei Li & Istvan Albert & Haiping Hao & Kristin M. Fabre & James B. Mitchell & Andrew D. Patterson & Frank J. Gonzalez, 2013. "Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity," Nature Communications, Nature, vol. 4(1), pages 1-10, December.
    4. Yuko Sato & Koji Atarashi & Damian R. Plichta & Yasumichi Arai & Satoshi Sasajima & Sean M. Kearney & Wataru Suda & Kozue Takeshita & Takahiro Sasaki & Shoki Okamoto & Ashwin N. Skelly & Yuki Okamura , 2021. "Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians," Nature, Nature, vol. 599(7885), pages 458-464, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Juan Salazar & Pablo Durán & María P. Díaz & Maricarmen Chacín & Raquel Santeliz & Edgardo Mengual & Emma Gutiérrez & Xavier León & Andrea Díaz & Marycarlota Bernal & Daniel Escalona & Luis Alberto Pa, 2023. "Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator," IJERPH, MDPI, vol. 20(10), pages 1-24, May.
    2. Youwen Qin & Xin Tong & Wei-Jian Mei & Yanshuang Cheng & Yuanqiang Zou & Kai Han & Jiehai Yu & Zhuye Jie & Tao Zhang & Shida Zhu & Xin Jin & Jian Wang & Huanming Yang & Xun Xu & Huanzi Zhong & Liang X, 2024. "Consistent signatures in the human gut microbiome of old- and young-onset colorectal cancer," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Michael DiMarzio & Brigida Rusconi & Neela H Yennawar & Mark Eppinger & Andrew D Patterson & Edward G Dudley, 2017. "Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-15, September.
    4. Romina Bonomini-Gnutzmann & Julio Plaza-Díaz & Carlos Jorquera-Aguilera & Andrés Rodríguez-Rodríguez & Fernando Rodríguez-Rodríguez, 2022. "Effect of Intensity and Duration of Exercise on Gut Microbiota in Humans: A Systematic Review," IJERPH, MDPI, vol. 19(15), pages 1-17, August.
    5. Yuanyuan Lei & Li Tang & Qiao Chen & Lingyi Wu & Wei He & Dianji Tu & Sumin Wang & Yuyang Chen & Shuang Liu & Zhuo Xie & Hong Wei & Shiming Yang & Bo Tang, 2022. "Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Christine Tara Peterson, 2024. "Gut Microbiota-Mediated Biotransformation of Medicinal Herb-Derived Natural Products: A Narrative Review of New Frontiers in Drug Discovery," J, MDPI, vol. 7(3), pages 1-22, September.
    7. Marwan E. Majzoub & Sudarshan Paramsothy & Craig Haifer & Rohit Parthasarathy & Thomas J. Borody & Rupert W. Leong & Michael A. Kamm & Nadeem O. Kaakoush, 2024. "The phageome of patients with ulcerative colitis treated with donor fecal microbiota reveals markers associated with disease remission," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    8. Kali M. Pruss & Haoqing Chen & Yuanyuan Liu & William Treuren & Steven K. Higginbottom & John B. Jarman & Curt R. Fischer & Justin Mak & Beverly Wong & Tina M. Cowan & Michael A. Fischbach & Justin L., 2023. "Host-microbe co-metabolism via MCAD generates circulating metabolites including hippuric acid," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    9. Ethan A. Older & Jian Zhang & Zachary E. Ferris & Dan Xue & Zheng Zhong & Mary K. Mitchell & Michael Madden & Yuzhen Wang & Hexin Chen & Prakash Nagarkatti & Mitzi Nagarkatti & Daping Fan & Melissa El, 2024. "Biosynthetic enzyme analysis identifies a protective role for TLR4-acting gut microbial sulfonolipids in inflammatory bowel disease," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37459-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.