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Neutrophil ageing is regulated by the microbiome

Author

Listed:
  • Dachuan Zhang

    (Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

  • Grace Chen

    (Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

  • Deepa Manwani

    (Albert Einstein College of Medicine)

  • Arthur Mortha

    (Mount Sinai School of Medicine
    The Immunology Institute, Mount Sinai School of Medicine)

  • Chunliang Xu

    (Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

  • Jeremiah J. Faith

    (The Immunology Institute, Mount Sinai School of Medicine
    The Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine)

  • Robert D. Burk

    (Albert Einstein College of Medicine)

  • Yuya Kunisaki

    (Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
    Albert Einstein College of Medicine
    †Present addresses: Department of Medicine and Biosystemic Science, Kyushu University, Fukuoka, Fukuoka 812-8582, Japan (Y.K.); Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-University, 81377 Munich, Germany (C.S.).)

  • Jung-Eun Jang

    (Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

  • Christoph Scheiermann

    (Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
    Albert Einstein College of Medicine
    †Present addresses: Department of Medicine and Biosystemic Science, Kyushu University, Fukuoka, Fukuoka 812-8582, Japan (Y.K.); Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-University, 81377 Munich, Germany (C.S.).)

  • Miriam Merad

    (Mount Sinai School of Medicine
    The Immunology Institute, Mount Sinai School of Medicine)

  • Paul S. Frenette

    (Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
    Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

Abstract

Neutrophil ageing, which encourages inflammation and vaso-occlusion in a mouse model of sickle-cell disease, is shown to depend on the intestinal microbiota and activation of the TLR/Myd88 signalling pathways.

Suggested Citation

  • Dachuan Zhang & Grace Chen & Deepa Manwani & Arthur Mortha & Chunliang Xu & Jeremiah J. Faith & Robert D. Burk & Yuya Kunisaki & Jung-Eun Jang & Christoph Scheiermann & Miriam Merad & Paul S. Frenette, 2015. "Neutrophil ageing is regulated by the microbiome," Nature, Nature, vol. 525(7570), pages 528-532, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7570:d:10.1038_nature15367
    DOI: 10.1038/nature15367
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    Cited by:

    1. Anastasiia Petenkova & Shelby A. Auger & Jeffrey Lamb & Daisy Quellier & Cody Carter & On Tak To & Jelena Milosevic & Rana Barghout & Abirami Kugadas & Xiaoxiao Lu & Jennifer Geddes-McAlister & Raina , 2023. "Prenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Meng Wang & Adeline Dehlinger & Camila Fernández Zapata & Maya Golan & Gerardina Gallaccio & Leif E. Sander & Stephan Schlickeiser & Desiree Kunkel & Tanja Schmitz-Hübsch & Birgit Sawitzki & Arnon Kar, 2023. "Associations of myeloid cells with cellular and humoral responses following vaccinations in patients with neuroimmunological diseases," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Marianna Ioannou & Dennis Hoving & Iker Valle Aramburu & Mia I. Temkin & Nathalia M. Vasconcelos & Theodora-Dorita Tsourouktsoglou & Qian Wang & Stefan Boeing & Robert Goldstone & Spyros Vernardis & V, 2022. "Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening," Nature Communications, Nature, vol. 13(1), pages 1-24, December.
    4. Jiaoling Chen & Yaxing Bai & Ke Xue & Zhiguo Li & Zhenlai Zhu & Qingyang Li & Chen Yu & Bing Li & Shengxian Shen & Pei Qiao & Caixia Li & Yixin Luo & Hongjiang Qiao & Erle Dang & Wen Yin & Johann E. G, 2023. "CREB1-driven CXCR4hi neutrophils promote skin inflammation in mouse models and human patients," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    5. Kun Wang & Muyun Wang & Ximing Liao & Shaoyong Gao & Jing Hua & Xiaodong Wu & Qian Guo & Wujian Xu & Jiaxing Sun & Yanan He & Qiang Li & Wei Gao, 2022. "Locally organised and activated Fth1hi neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    6. Juan Salazar & Pablo Durán & María P. Díaz & Maricarmen Chacín & Raquel Santeliz & Edgardo Mengual & Emma Gutiérrez & Xavier León & Andrea Díaz & Marycarlota Bernal & Daniel Escalona & Luis Alberto Pa, 2023. "Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator," IJERPH, MDPI, vol. 20(10), pages 1-24, May.

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