IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v16y2019i20p3833-d275153.html
   My bibliography  Save this article

Radical Hysterectomy After Neoadjuvant Chemotherapy for Locally Bulky-Size Cervical Cancer: A Retrospective Comparative Analysis between the Robotic and Abdominal Approaches

Author

Listed:
  • Chia-Hao Liu

    (Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
    Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan)

  • Yu-Chieh Lee

    (Department of Obstetrics and Gynecology, Taipei Medical University Hospital and Taipei Medical University, Taipei 110, Taiwan)

  • Jeff Chien-Fu Lin

    (Department of Statistics, National Taipei University, Taipei 104, Taiwan
    Department of Orthopedic Surgery, Taipei Municipal Wanfang Hospital, Taipei Medical University, Taipei 116, Taiwan)

  • I-San Chan

    (Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
    Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan)

  • Na-Rong Lee

    (Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
    Department of Nursing, Taipei Veterans General Hospital, Taipei 112, Taiwan)

  • Wen-Hsun Chang

    (Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
    Department of Nursing, Taipei Veterans General Hospital, Taipei 112, Taiwan)

  • Wei-Min Liu

    (Department of Obstetrics and Gynecology, Taipei Medical University Hospital and Taipei Medical University, Taipei 110, Taiwan)

  • Peng-Hui Wang

    (Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
    Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan
    Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan
    Department of Medical Research, China Medical University Hospital, Taichung 440, Taiwan)

Abstract

Radical hysterectomy (RH) is the standard treatment for early stage cervical cancer, but the surgical approach for locally bulky-size cervical cancer (LBS-CC) is still unclear. We retrospectively compared the outcomes of women with LBS-CC treated with neoadjuvant chemotherapy (NACT) and subsequent RH between the robotic (R-RH) and abdominal approaches (A-RH). Between 2012 and 2014, 39 women with LBS-CC FIGO (International Federation of Gynecology and Obstetrics) stage IB2–IIB were treated with NACT-R-RH ( n = 18) or NACT-A-RH ( n = 21). Surgical parameters and prognosis were compared. Patient characteristics were not significantly different between the groups, but the NACT-R-RH group had significantly more patients with FIGO stage IIB disease, received multi-agent-based NACT, and had a lower percentage of deep stromal invasion than the NACT-A-RH group. After NACT-R-RH, surgical parameters were better, but survival outcomes, such as disease-free survival (DFS) and overall survival (OS), were significantly worse. On multivariate analysis, FIGO stage IIB contributed to worse DFS ( p = 0.003) and worse OS ( p = 0.012) in the NACT-A-RH group. Women with LBS-CC treated with NACT-R-RH have better perioperative outcomes but poorer survival outcomes compared with those treated with NACT-A-RH. Thus, patients with FIGO stage IIB LBS-CC disease might not be suitable for surgery after multi-agent-based NACT.

Suggested Citation

  • Chia-Hao Liu & Yu-Chieh Lee & Jeff Chien-Fu Lin & I-San Chan & Na-Rong Lee & Wen-Hsun Chang & Wei-Min Liu & Peng-Hui Wang, 2019. "Radical Hysterectomy After Neoadjuvant Chemotherapy for Locally Bulky-Size Cervical Cancer: A Retrospective Comparative Analysis between the Robotic and Abdominal Approaches," IJERPH, MDPI, vol. 16(20), pages 1-19, October.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:20:p:3833-:d:275153
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/16/20/3833/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/16/20/3833/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Chun-Ku Chen & Hsiao-Ting Chang & Yu-Chun Chen & Shu-Chiung Chiang & Hsiao-Ping Chou & Tzeng-Ji Chen, 2019. "Utilization and Safety of Percutaneous Lung Biopsy: A 10-Year Nationwide Population-Based Study," IJERPH, MDPI, vol. 16(8), pages 1-10, April.
    2. Jarim Kim, 2018. "The Relationship of Health Beliefs with Information Sources and HPV Vaccine Acceptance among Young Adults in Korea," IJERPH, MDPI, vol. 15(4), pages 1-11, April.
    3. Yue-Mei Jin & Shan-Shan Liu & Jun Chen & Yan-Nan Chen & Chen-Chen Ren, 2018. "Robotic radical hysterectomy is superior to laparoscopic radical hysterectomy and open radical hysterectomy in the treatment of cervical cancer," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-14, March.
    4. Concetta Paola Pelullo & Maria Rosaria Esposito & Gabriella Di Giuseppe, 2019. "Human Papillomavirus Infection and Vaccination: Knowledge and Attitudes among Nursing Students in Italy," IJERPH, MDPI, vol. 16(10), pages 1-9, May.
    5. Vincenzo Restivo & Claudio Costantino & Antonello Marras & Giuseppe Napoli & Sabrina Scelfo & Tiziana Scuderi & Alessandra Casuccio & Achille Cernigliaro & Angela Giusti & Stefania Spila Alegiani, 2018. "Pap Testing in a High-Income Country with Suboptimal Compliance Levels: A Survey on Acceptance Factors among Sicilian Women," IJERPH, MDPI, vol. 15(9), pages 1-10, August.
    6. Chieh-Sen Chuang & Kai-Wei Yang & Chia-Ming Yen & Cheng-Li Lin & Chia-Hung Kao, 2019. "Risk of Seizures in Patients with Organophosphate Poisoning: A Nationwide Population-Based Study," IJERPH, MDPI, vol. 16(17), pages 1-9, August.
    7. Ching Tong & Yu-Hsun Wang & Yu-Chao Chang, 2019. "Increased Risk of Carotid Atherosclerosis in Male Patients with Chronic Periodontitis: A Nationwide Population-Based Retrospective Cohort Study," IJERPH, MDPI, vol. 16(15), pages 1-8, July.
    8. Ha Kyun Chang & Sang-Soo Seo & Jun-Pyo Myong & Jung-Wan Koo & Jinhee Jeong, 2018. "Factors Associated with Cervical Cancer Screening among Married Female Immigrants with Korean Husbands in South Korea," IJERPH, MDPI, vol. 15(11), pages 1-10, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yung-Kai Huang & Li-Chiu Yang & Yu-Hsun Wang & Yu-Chao Chang, 2021. "Increased Risk of Migraine in Patients with Chronic Periodontitis: A Population-Based Cohort Study," IJERPH, MDPI, vol. 18(4), pages 1-10, February.
    2. Matthew Asare & Peter Agyei-Baffour & Beth A. Lanning & Alex Barimah Owusu & Mary E. Commeh & Kathileen Boozer & Adofo Koranteng & Lori A. Spies & Jane R. Montealegre & Electra D. Paskett, 2020. "Multi-Theory Model and Predictors of Likelihood of Accepting the Series of HPV Vaccination: A Cross-Sectional Study among Ghanaian Adolescents," IJERPH, MDPI, vol. 17(2), pages 1-13, January.
    3. Claudio Costantino & Alessandra Casuccio & Vincenzo Restivo, 2020. "Potential Risks and Factors of Women’s Health Promotion," IJERPH, MDPI, vol. 17(24), pages 1-7, December.
    4. Ssirai Kim & Sun-Young Lee & Smi Choi-Kwon, 2020. "Cervical Cancer Screening and Human Papillomavirus Vaccination among Korean Sexual Minority Women by Sex of Their Sexual Partners," IJERPH, MDPI, vol. 17(23), pages 1-11, November.
    5. Xingyuan Wang & Yun Liu & Hongchen Liu, 2020. "Examining Users’ Adoption of Precision Medicine: The Moderating Role of Medical Technical Knowledge," IJERPH, MDPI, vol. 17(3), pages 1-16, February.
    6. Szu-Chun Yang & Ching-Han Lai & Chin-Wei Kuo & Chien-Chung Lin & Wu-Wei Lai & Jung-Der Wang, 2021. "Downstream Complications and Healthcare Expenditure after Invasive Procedures for Lung Lesions in Taiwan," IJERPH, MDPI, vol. 18(8), pages 1-9, April.
    7. Sara Villanueva & Diego Gabriel Mosteiro-Miguéns & Eva María Domínguez-Martís & David López-Ares & Silvia Novío, 2019. "Knowledge, Attitudes, and Intentions towards Human Papillomavirus Vaccination among Nursing Students in Spain," IJERPH, MDPI, vol. 16(22), pages 1-14, November.
    8. Jinhee Jeong & Yunhee Lee & Sung Hee Kwon & Jun-Pyo Myong, 2019. "Factors Associated with General Health Screening Participation among Married Immigrant Women in Korea," IJERPH, MDPI, vol. 16(20), pages 1-9, October.
    9. Li-Chiu Yang & Yih-Jane Suen & Yu-Hsun Wang & Tai-Chen Lin & Hui-Chieh Yu & Yu-Chao Chang, 2020. "The Association of Periodontal Treatment and Decreased Pneumonia: A Nationwide Population-Based Cohort Study," IJERPH, MDPI, vol. 17(1), pages 1-10, January.
    10. Giuseppa Minutolo & Palmira Immordino & Alessia Dolce & Mario Valenza & Emanuele Amodio & Walter Mazzucco & Alessandra Casuccio & Vincenzo Restivo, 2022. "Could a Behavioral Model Explain Adherence to Second-Level Colonoscopy for Colon Cancer Screening? Results of a Cross-Sectional Study of the Palermo Province Population," IJERPH, MDPI, vol. 19(5), pages 1-12, February.
    11. Jarim Kim & Yerim Kim, 2021. "What Predicts Korean Citizens’ Mask-Wearing Behaviors? Health Beliefs and Protective Behaviors against Particulate Matter," IJERPH, MDPI, vol. 18(6), pages 1-11, March.
    12. José Tuells & Cecilia M. Egoavil & Isabel Morales-Moreno & Elena Fortes-Montoya & Carlos Salazar-García & Noelia Rodríguez-Blanco, 2021. "Knowledge, Attitudes, and Sources of Information on Vaccines in Spanish Nursing Students: A Cross-Sectional Study," IJERPH, MDPI, vol. 18(7), pages 1-17, March.
    13. Xin Wang & Taifeng Du & Xiaoling Shi & Kusheng Wu, 2021. "Awareness and Knowledge about Human Papilloma Virus Infection among Students at Secondary Occupational Health School in China," IJERPH, MDPI, vol. 18(12), pages 1-11, June.
    14. Esther E. Idehen & Anni Virtanen & Eero Lilja & Tomi-Pekka Tuomainen & Tellervo Korhonen & Päivikki Koponen, 2020. "Cervical Cancer Screening Participation among Women of Russian, Somali, and Kurdish Origin Compared with the General Finnish Population: A Register-Based Study," IJERPH, MDPI, vol. 17(21), pages 1-16, October.
    15. Mbah Ntepe Leonel Javeres & Rabia Habib & Ngondi Judith Laure & Syed Tahir Abbas Shah & Martin Valis & Kamil Kuca & Syed Muhammad Nurulain, 2021. "Chronic Exposure to Organophosphates Pesticides and Risk of Metabolic Disorder in Cohort from Pakistan and Cameroon," IJERPH, MDPI, vol. 18(5), pages 1-13, February.
    16. Achille Cernigliaro & Sara Palmeri & Alessandra Casuccio & Salvatore Scondotto & Vincenzo Restivo & In Primis Working Group, 2019. "Association of the Individual and Context Inequalities on the Breastfeeding: A Study from the Sicily Region," IJERPH, MDPI, vol. 16(19), pages 1-11, September.
    17. Ying-Ting Yeh & Yen-Shuo Tseng & Yi-Liang Wu & Shun-Fa Yang & Bo-Yuan Wang & Yu-Hsun Wang & Liang-Tsai Yeh & Ying-Tung Yeh & Chi-Ho Chan, 2022. "Risk of Peripheral Arterial Occlusive Disease with Periodontitis and Dental Scaling: A Nationwide Population-Based Cohort Study," IJERPH, MDPI, vol. 19(16), pages 1-11, August.
    18. Neice Muller Xavier Faria & Rodrigo Dalke Meucci & Nadia Spada Fiori & Maria Laura Vidal Carret & Carlos Augusto Mello-da-Silva & Anaclaudia Gastal Fassa, 2023. "Acute Pesticide Poisoning in Tobacco Farming, According to Different Criteria," IJERPH, MDPI, vol. 20(4), pages 1-17, February.
    19. Yung-Kai Huang & Yu-Hsun Wang & Yu-Chao Chang, 2020. "Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study," IJERPH, MDPI, vol. 17(10), pages 1-8, May.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:16:y:2019:i:20:p:3833-:d:275153. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.