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Risk of Seizures in Patients with Organophosphate Poisoning: A Nationwide Population-Based Study

Author

Listed:
  • Chieh-Sen Chuang

    (Department of Neurology, Changhua Christian Hospital, Changhua 50006, Taiwan)

  • Kai-Wei Yang

    (Department of Emergency, China Medical University Hospital, Taichung 40447, Taiwan)

  • Chia-Ming Yen

    (Department of Anesthesiology, Buddhist Tzu Chi General Hospital, Taichung 40447, Taiwan
    Department of Graduate Institute of Acupuncture Science, China Medical University, Taichung 40447, Taiwan)

  • Cheng-Li Lin

    (Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan
    College of Medicine, China Medical University, Taichung 40447, Taiwan)

  • Chia-Hung Kao

    (Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung 40447, Taiwan
    Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung 40447, Taiwan
    Department of Bioinformatics and Medical Engineering, Asia University, Taichung 41354, Taiwan
    Center of Augmented Intelligence in Healthcare, China Medical University Hospital, Taichung 40447, Taiwan)

Abstract

Objective: Previous research has demonstrated that patients with a history of organophosphate poisoning tend to have a higher risk of neurological disorder. However, research on the rate of seizure development in patients after organophosphate poisoning is lacking. This study examined whether individuals with organophosphate poisoning have an increased risk of seizures through several years of follow-up. Patients and Methods: We conducted a retrospective study on a cohort of 45,060 individuals (9012 patients with a history of organophosphate poisoning and 36,048 controls) selected from the Taiwan National Health Insurance Research Database. The individuals were observed for a maximum of 12 years to determine the rate of new-onset seizure disorder. We selected a comparison cohort from the general population that was randomly frequency-matched by age, sex, and index year and further analyzed the risk of seizures using a Cox regression model adjusted for sex, age, and comorbidities. Results: During the study period, the risk of seizure development was 3.57 times greater in patients with organophosphate poisoning compared with individuals without, after adjustments for age, sex, and comorbidities. The absolute incidence of seizures was highest in individuals aged 20 to 34 years in both cohorts (adjusted hazard ratio = 13.0, 95% confidence interval = 5.40−31.4). A significantly higher seizure risk was also observed in patients with organophosphate poisoning and comorbidities other than cirrhosis. Conclusions: This nationwide retrospective cohort study demonstrates that seizure risk is significantly increased in patients with organophosphate poisoning compared with the general population.

Suggested Citation

  • Chieh-Sen Chuang & Kai-Wei Yang & Chia-Ming Yen & Cheng-Li Lin & Chia-Hung Kao, 2019. "Risk of Seizures in Patients with Organophosphate Poisoning: A Nationwide Population-Based Study," IJERPH, MDPI, vol. 16(17), pages 1-9, August.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:17:p:3147-:d:261925
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    Citations

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    Cited by:

    1. Chia-Hao Liu & Yu-Chieh Lee & Jeff Chien-Fu Lin & I-San Chan & Na-Rong Lee & Wen-Hsun Chang & Wei-Min Liu & Peng-Hui Wang, 2019. "Radical Hysterectomy After Neoadjuvant Chemotherapy for Locally Bulky-Size Cervical Cancer: A Retrospective Comparative Analysis between the Robotic and Abdominal Approaches," IJERPH, MDPI, vol. 16(20), pages 1-19, October.
    2. Mbah Ntepe Leonel Javeres & Rabia Habib & Ngondi Judith Laure & Syed Tahir Abbas Shah & Martin Valis & Kamil Kuca & Syed Muhammad Nurulain, 2021. "Chronic Exposure to Organophosphates Pesticides and Risk of Metabolic Disorder in Cohort from Pakistan and Cameroon," IJERPH, MDPI, vol. 18(5), pages 1-13, February.
    3. Neice Muller Xavier Faria & Rodrigo Dalke Meucci & Nadia Spada Fiori & Maria Laura Vidal Carret & Carlos Augusto Mello-da-Silva & Anaclaudia Gastal Fassa, 2023. "Acute Pesticide Poisoning in Tobacco Farming, According to Different Criteria," IJERPH, MDPI, vol. 20(4), pages 1-17, February.

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