IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i4p1921-d500531.html
   My bibliography  Save this article

Increased Risk of Migraine in Patients with Chronic Periodontitis: A Population-Based Cohort Study

Author

Listed:
  • Yung-Kai Huang

    (Department of Oral Hygiene, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

  • Li-Chiu Yang

    (School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan)

  • Yu-Hsun Wang

    (Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

  • Yu-Chao Chang

    (School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

Abstract

Migraine is considered to be a neurovascular disease that manifests as a throbbing headache, possibly caused by the activation of the trigeminovascular system. Several studies have supported the role of inflammation in the pathogenesis of migraine. Chronic periodontitis (CP) is an infectious inflammatory disease triggered by bacterial products evoking an immune response which could result in the destruction of the periodontium. However, little is known about the longitudinal association between CP and migraine. In this study, we designed a nationwide population-based cohort study to investigate the risk of migraine and CP exposure in Taiwan. In total, 68,282 patients with CP were identified from the National Health Insurance Research Database (NHIRD), and 68,282 comparisons were randomly captured and matched by age, sex, monthly income, urbanization and comorbidities. The association between CP exposure and migraine risk was evaluated by Cox proportional hazards regression models. In this study, 785 migraine patients were identified in the CP cohort, and 641 migraine cases were found in the non-CP cohort. The incidence rate of migraine was significantly higher in the CP cohort than the non-CP cohort (adjusted HR: 1.21, 95% CI: 1.09–1.34, p < 0.001) during the 13-year follow-up period. Females had a 2.69-fold higher risk for migraine than males (95% CI: 2.38–3.04, p < 0.001). In summary, CP is associated with an increased risk of subsequent migraine in Taiwan.

Suggested Citation

  • Yung-Kai Huang & Li-Chiu Yang & Yu-Hsun Wang & Yu-Chao Chang, 2021. "Increased Risk of Migraine in Patients with Chronic Periodontitis: A Population-Based Cohort Study," IJERPH, MDPI, vol. 18(4), pages 1-10, February.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:4:p:1921-:d:500531
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/4/1921/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/18/4/1921/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Yung-Kai Huang & Yu-Hsun Wang & Yu-Chao Chang, 2020. "Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study," IJERPH, MDPI, vol. 17(10), pages 1-8, May.
    2. Li-Chiu Yang & Yih-Jane Suen & Yu-Hsun Wang & Tai-Chen Lin & Hui-Chieh Yu & Yu-Chao Chang, 2020. "The Association of Periodontal Treatment and Decreased Pneumonia: A Nationwide Population-Based Cohort Study," IJERPH, MDPI, vol. 17(1), pages 1-10, January.
    3. Chien-Fang Tseng & Kun-Huang Chen & Hui-Chieh Yu & Fu-Mei Huang & Yu-Chao Chang, 2020. "Dental Amalgam Fillings and Multiple Sclerosis: A Nationwide Population-Based Case–Control Study in Taiwan," IJERPH, MDPI, vol. 17(8), pages 1-7, April.
    4. Ching Tong & Yu-Hsun Wang & Yu-Chao Chang, 2019. "Increased Risk of Carotid Atherosclerosis in Male Patients with Chronic Periodontitis: A Nationwide Population-Based Retrospective Cohort Study," IJERPH, MDPI, vol. 16(15), pages 1-8, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yung-Kai Huang & Yu-Hsun Wang & Yu-Chao Chang, 2020. "Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study," IJERPH, MDPI, vol. 17(10), pages 1-8, May.
    2. Chia-Hao Liu & Yu-Chieh Lee & Jeff Chien-Fu Lin & I-San Chan & Na-Rong Lee & Wen-Hsun Chang & Wei-Min Liu & Peng-Hui Wang, 2019. "Radical Hysterectomy After Neoadjuvant Chemotherapy for Locally Bulky-Size Cervical Cancer: A Retrospective Comparative Analysis between the Robotic and Abdominal Approaches," IJERPH, MDPI, vol. 16(20), pages 1-19, October.
    3. Li-Chiu Yang & Yih-Jane Suen & Yu-Hsun Wang & Tai-Chen Lin & Hui-Chieh Yu & Yu-Chao Chang, 2020. "The Association of Periodontal Treatment and Decreased Pneumonia: A Nationwide Population-Based Cohort Study," IJERPH, MDPI, vol. 17(1), pages 1-10, January.
    4. Chien-Fang Tseng & Kun-Huang Chen & Hui-Chieh Yu & Fu-Mei Huang & Yu-Chao Chang, 2020. "Dental Amalgam Fillings and Multiple Sclerosis: A Nationwide Population-Based Case–Control Study in Taiwan," IJERPH, MDPI, vol. 17(8), pages 1-7, April.
    5. Ying-Ting Yeh & Yen-Shuo Tseng & Yi-Liang Wu & Shun-Fa Yang & Bo-Yuan Wang & Yu-Hsun Wang & Liang-Tsai Yeh & Ying-Tung Yeh & Chi-Ho Chan, 2022. "Risk of Peripheral Arterial Occlusive Disease with Periodontitis and Dental Scaling: A Nationwide Population-Based Cohort Study," IJERPH, MDPI, vol. 19(16), pages 1-11, August.
    6. Yi-Wei Kao & Ben-Chang Shia & Huei-Chen Chiang & Mingchih Chen & Szu-Yuan Wu, 2021. "Association of Tooth Scaling with Acute Myocardial Infarction and Analysis of the Corresponding Medical Expenditure: A Nationwide Population-Based Study," IJERPH, MDPI, vol. 18(14), pages 1-8, July.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:4:p:1921-:d:500531. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.