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Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study

Author

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  • Yung-Kai Huang

    (Department of Oral Hygiene, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

  • Yu-Hsun Wang

    (Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

  • Yu-Chao Chang

    (School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

Abstract

Bipolar disorder (BD) is a psychiatric mood disturbance manifested by manic, hypomanic, or major depressive periods. Chronic inflammation was evidenced as an important etiologic factor of BD. Chronic periodontitis (CP) is an inflammatory disease triggered by bacterial products, leading to the destruction of periodontium. The relationship between BD and CP is of interest to investigate. Therefore, a nationwide population-based cohort study was used to investigate the risk of BD and CP exposure from 2001 to 2012. We identified 61,608 patients with CP from the Taiwanese National Health Insurance Research Database (NHIRD). The 123,216 controls were randomly captured and matched by age, sex, index year, and co-morbidities. The association between CP exposure and BD risk was examined by Cox proportional hazards regression models. In this study, 61,608 CP patients and 123,216 controls were followed up for 7.45 and 7.36 years, respectively. In total, 138 BD patients were identified in the CP cohort and 187 BD cases were found in the non-CP cohort. The incidence rate of BD was significantly higher in the CP cohort than in the non-CP cohort (adjusted HR: 1.46, 95% CI: 1.17–1.81) according to the multivariate Cox regression analysis. Females had a 1.47-fold increased risk (95% CI: 1.16–1.86) for BD compared to males. Taken together, CP may be associated with an increased risk of subsequent BD in Taiwan.

Suggested Citation

  • Yung-Kai Huang & Yu-Hsun Wang & Yu-Chao Chang, 2020. "Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study," IJERPH, MDPI, vol. 17(10), pages 1-8, May.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:10:p:3466-:d:358747
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    References listed on IDEAS

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    1. Hui-Chieh Yu & Tsung-Po Chen & Chia-Yi Wei & Yu-Chao Chang, 2018. "Association between Peptic Ulcer Disease and Periodontitis: A Nationwide Population-Based Case-Control Study in Taiwan," IJERPH, MDPI, vol. 15(5), pages 1-8, May.
    2. Li-Chiu Yang & Yih-Jane Suen & Yu-Hsun Wang & Tai-Chen Lin & Hui-Chieh Yu & Yu-Chao Chang, 2020. "The Association of Periodontal Treatment and Decreased Pneumonia: A Nationwide Population-Based Cohort Study," IJERPH, MDPI, vol. 17(1), pages 1-10, January.
    3. Chang-Yu Lee & Cheuk-Sing Choy & Yu-Cheng Lai & Chao-Chien Chang & Nai-Chia Teng & Wan-Ting Huang & Che-Tong Lin & Yung-Kai Huang, 2019. "A Cross-Sectional Study of Endogenous Antioxidants and Patterns of Dental Visits of Periodontitis Patients," IJERPH, MDPI, vol. 16(2), pages 1-16, January.
    4. Chang-Kai Chen & Jing-Yang Huang & Yung-Tsan Wu & Yu-Chao Chang, 2018. "Dental Scaling Decreases the Risk of Parkinson’s Disease: A Nationwide Population-Based Nested Case-Control Study," IJERPH, MDPI, vol. 15(8), pages 1-8, July.
    5. Ching Tong & Yu-Hsun Wang & Yu-Chao Chang, 2019. "Increased Risk of Carotid Atherosclerosis in Male Patients with Chronic Periodontitis: A Nationwide Population-Based Retrospective Cohort Study," IJERPH, MDPI, vol. 16(15), pages 1-8, July.
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    1. Yung-Kai Huang & Li-Chiu Yang & Yu-Hsun Wang & Yu-Chao Chang, 2021. "Increased Risk of Migraine in Patients with Chronic Periodontitis: A Population-Based Cohort Study," IJERPH, MDPI, vol. 18(4), pages 1-10, February.

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