IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i5p2310-d506558.html
   My bibliography  Save this article

Chronic Exposure to Organophosphates Pesticides and Risk of Metabolic Disorder in Cohort from Pakistan and Cameroon

Author

Listed:
  • Mbah Ntepe Leonel Javeres

    (Department of Biosciences, COMSATS University Islamabad, Chak Shahzad, Islamabad 45550, Pakistan
    Institute of Medical Research and Medical Plants Studies, Yaounde 1457, Cameroon)

  • Rabia Habib

    (Department of Biosciences, COMSATS University Islamabad, Chak Shahzad, Islamabad 45550, Pakistan)

  • Ngondi Judith Laure

    (Department of Biochemistry, Yaoundé I University, Yaoundé 8024, Cameroon)

  • Syed Tahir Abbas Shah

    (Department of Biosciences, COMSATS University Islamabad, Chak Shahzad, Islamabad 45550, Pakistan)

  • Martin Valis

    (Department of Neurology of the Medical Faculty of Charles University and University Hospital in Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic)

  • Kamil Kuca

    (Biomedical Research Center, University Hospital in Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic
    Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic)

  • Syed Muhammad Nurulain

    (Department of Biosciences, COMSATS University Islamabad, Chak Shahzad, Islamabad 45550, Pakistan)

Abstract

(1) Background: Organophosphorus pesticides (OPPs) are major chemicals used in agriculture for eradication of insecticides/pesticides. Unfortunately, the longtime exposure of human beings to OPPs could lead to metabolic disorder such as high blood pressure, hyperglycemia, overweight or dyslipidemia. The aim of this research is to evaluate the possible metabolic dysregulations as a consequence of chronic OPPs exposure to individuals in Cameroon and Pakistan. (2) Methods: Blood samples were collected from 300 participants in each country, into ethylenediaminetetraacetic acid (EDTA) tubes. The samples were extracted with solid phase extraction (methanol/water) for analysis of OPPs with gas chromatography mass spectrometry. The spectrophotometry and Enzyme Linked ImmunoSorbent Assay (ELISA) were used to measure the hepatic, renal, pancreatic and cardiovascular functions. The atherogenic index (AI) was also determined in OPPs exposed and nonexposed cohorts. (3) Results: The results showed the presence of malathion, parathion and chlorpyrifos OPPs residues in Cameroonians, and malathion and chlorpyrifos in Pakistani samples, respectively. Elevated Body Mass Index (BMI), insulin, blood glucose, dyslipidemia and hypertension were noted in OPPs chronic exposed groups. In addition, dysregulated liver and kidney function profiles were observed in all participants regardless of gender and age groups. (4) Conclusions: The study concludes that both the study cohorts showed several metabolic dysregulations attributable to chronic exposure to a mixture of OPPs which may provide precursors for establishment of metabolic syndrome and other chronic diseases. Further different extended population-based studies are suggested to understand the differential metabolic dysfunctions caused by structurally different OPPs mixtures exposure.

Suggested Citation

  • Mbah Ntepe Leonel Javeres & Rabia Habib & Ngondi Judith Laure & Syed Tahir Abbas Shah & Martin Valis & Kamil Kuca & Syed Muhammad Nurulain, 2021. "Chronic Exposure to Organophosphates Pesticides and Risk of Metabolic Disorder in Cohort from Pakistan and Cameroon," IJERPH, MDPI, vol. 18(5), pages 1-13, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:5:p:2310-:d:506558
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/5/2310/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/5/2310/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Yuan Kei Ching & Yit Siew Chin & Mahenderan Appukutty & Wan Ying Gan & Vasudevan Ramanchadran & Yoke Mun Chan, 2018. "Prevalence of Metabolic Syndrome and Its Associated Factors among Vegetarians in Malaysia," IJERPH, MDPI, vol. 15(9), pages 1-15, September.
    2. Chieh-Sen Chuang & Kai-Wei Yang & Chia-Ming Yen & Cheng-Li Lin & Chia-Hung Kao, 2019. "Risk of Seizures in Patients with Organophosphate Poisoning: A Nationwide Population-Based Study," IJERPH, MDPI, vol. 16(17), pages 1-9, August.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yamdeu Joseph Hubert Galani & Michael Houbraken & Abukari Wumbei & Joseph Fovo Djeugap & Daniel Fotio & Yun Yun Gong & Pieter Spanoghe, 2021. "Contamination of Foods from Cameroon with Residues of 20 Halogenated Pesticides, and Health Risk of Adult Human Dietary Exposure," IJERPH, MDPI, vol. 18(9), pages 1-26, May.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Chia-Hao Liu & Yu-Chieh Lee & Jeff Chien-Fu Lin & I-San Chan & Na-Rong Lee & Wen-Hsun Chang & Wei-Min Liu & Peng-Hui Wang, 2019. "Radical Hysterectomy After Neoadjuvant Chemotherapy for Locally Bulky-Size Cervical Cancer: A Retrospective Comparative Analysis between the Robotic and Abdominal Approaches," IJERPH, MDPI, vol. 16(20), pages 1-19, October.
    2. Ming-Shu Chen & Shih-Hsin Chen, 2018. "A Data-Driven Assessment of the Metabolic Syndrome Criteria for Adult Health Management in Taiwan," IJERPH, MDPI, vol. 16(1), pages 1-11, December.
    3. Neice Muller Xavier Faria & Rodrigo Dalke Meucci & Nadia Spada Fiori & Maria Laura Vidal Carret & Carlos Augusto Mello-da-Silva & Anaclaudia Gastal Fassa, 2023. "Acute Pesticide Poisoning in Tobacco Farming, According to Different Criteria," IJERPH, MDPI, vol. 20(4), pages 1-17, February.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:5:p:2310-:d:506558. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.