IDEAS home Printed from https://ideas.repec.org/a/eee/thpobi/v81y2012i2p144-157.html
   My bibliography  Save this article

The structure of allelic diversity in the presence of purifying selection

Author

Listed:
  • Desai, Michael M.
  • Nicolaisen, Lauren E.
  • Walczak, Aleksandra M.
  • Plotkin, Joshua B.

Abstract

In the absence of selection, the structure of equilibrium allelic diversity is described by the elegant sampling formula of Ewens. This formula has helped to shape our expectations of empirical patterns of molecular variation. Along with coalescent theory, it provides statistical techniques for rejecting the null model of neutrality. However, we still do not fully understand the statistics of the allelic diversity expected in the presence of natural selection. Earlier work has described the effects of strongly deleterious mutations linked to many neutral sites, and allelic variation in models where offspring fitness is unrelated to parental fitness, but it has proven difficult to understand allelic diversity in the presence of purifying selection at many linked sites. Here, we study the population genetics of infinitely many perfectly linked sites, some neutral and some deleterious. Our approach is based on studying the lineage structure within each class of individuals of similar fitness in the deleterious mutation-selection balance. Consistent with previous observations, we find that for moderate and weak selection pressures, the patterns of allelic diversity cannot be described by a neutral model for any choice of the effective population site. We compute precisely how purifying selection at many linked sites distorts the patterns of allelic diversity, by developing expressions for the likelihood of any configuration of allelic types in a sample analogous to the Ewens sampling formula.

Suggested Citation

  • Desai, Michael M. & Nicolaisen, Lauren E. & Walczak, Aleksandra M. & Plotkin, Joshua B., 2012. "The structure of allelic diversity in the presence of purifying selection," Theoretical Population Biology, Elsevier, vol. 81(2), pages 144-157.
    • Handle: RePEc:eee:thpobi:v:81:y:2012:i:2:p:144-157
    DOI: 10.1016/j.tpb.2011.12.002
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0040580911001055
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.tpb.2011.12.002?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Etheridge, Alison M. & Griffiths, Robert C. & Taylor, Jesse E., 2010. "A coalescent dual process in a Moran model with genic selection, and the lambda coalescent limit," Theoretical Population Biology, Elsevier, vol. 78(2), pages 77-92.
    2. Ethier, S. N. & Kurtz, Thomas G., 1994. "Convergence to Fleming-Viot processes in the weak atomic topology," Stochastic Processes and their Applications, Elsevier, vol. 54(1), pages 1-27, November.
    3. Etheridge, A.M. & Griffiths, R.C., 2009. "A coalescent dual process in a Moran model with genic selection," Theoretical Population Biology, Elsevier, vol. 75(4), pages 320-330.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Malaguti, Giulia & Singh, Param Priya & Isambert, Hervé, 2014. "On the retention of gene duplicates prone to dominant deleterious mutations," Theoretical Population Biology, Elsevier, vol. 93(C), pages 38-51.
    2. Griffiths, Robert C. & Jenkins, Paul A. & Lessard, Sabin, 2016. "A coalescent dual process for a Wright–Fisher diffusion with recombination and its application to haplotype partitioning," Theoretical Population Biology, Elsevier, vol. 112(C), pages 126-138.
    3. Möhle, Martin, 2024. "On multi-type Cannings models and multi-type exchangeable coalescents," Theoretical Population Biology, Elsevier, vol. 156(C), pages 103-116.
    4. Der, Ricky & Epstein, Charles L. & Plotkin, Joshua B., 2011. "Generalized population models and the nature of genetic drift," Theoretical Population Biology, Elsevier, vol. 80(2), pages 80-99.
    5. Kon Kam King, Guillaume & Pandolfi, Andrea & Piretto, Marco & Ruggiero, Matteo, 2024. "Approximate filtering via discrete dual processes," Stochastic Processes and their Applications, Elsevier, vol. 168(C).
    6. Mikula, Lynette Caitlin & Vogl, Claus, 2024. "The expected sample allele frequencies from populations of changing size via orthogonal polynomials," Theoretical Population Biology, Elsevier, vol. 157(C), pages 55-85.
    7. Vogl, Claus & Clemente, Florian, 2012. "The allele-frequency spectrum in a decoupled Moran model with mutation, drift, and directional selection, assuming small mutation rates," Theoretical Population Biology, Elsevier, vol. 81(3), pages 197-209.
    8. Steinrücken, Matthias & Wang, Y.X. Rachel & Song, Yun S., 2013. "An explicit transition density expansion for a multi-allelic Wright–Fisher diffusion with general diploid selection," Theoretical Population Biology, Elsevier, vol. 83(C), pages 1-14.
    9. Etheridge, Alison M. & Griffiths, Robert C. & Taylor, Jesse E., 2010. "A coalescent dual process in a Moran model with genic selection, and the lambda coalescent limit," Theoretical Population Biology, Elsevier, vol. 78(2), pages 77-92.
    10. Lenz, Ute & Kluth, Sandra & Baake, Ellen & Wakolbinger, Anton, 2015. "Looking down in the ancestral selection graph: A probabilistic approach to the common ancestor type distribution," Theoretical Population Biology, Elsevier, vol. 103(C), pages 27-37.
    11. Vogl, Claus & Mikula, Lynette Caitlin, 2021. "A nearly-neutral biallelic Moran model with biased mutation and linear and quadratic selection," Theoretical Population Biology, Elsevier, vol. 139(C), pages 1-17.
    12. A. Dawson, Donald & Feng, Shui, 2001. "Large deviations for the Fleming-Viot process with neutral mutation and selection, II," Stochastic Processes and their Applications, Elsevier, vol. 92(1), pages 131-162, March.
    13. Feng, Shui, 2009. "Poisson-Dirichlet distribution with small mutation rate," Stochastic Processes and their Applications, Elsevier, vol. 119(6), pages 2082-2094, June.
    14. Champagnat, Nicolas & Hass, Vincent, 2023. "Existence, uniqueness and ergodicity for the centered Fleming–Viot process," Stochastic Processes and their Applications, Elsevier, vol. 166(C).
    15. Schrempf, Dominik & Hobolth, Asger, 2017. "An alternative derivation of the stationary distribution of the multivariate neutral Wright–Fisher model for low mutation rates with a view to mutation rate estimation from site frequency data," Theoretical Population Biology, Elsevier, vol. 114(C), pages 88-94.
    16. Dawson, Donald A. & Feng, Shui, 1998. "Large deviations for the Fleming-Viot process with neutral mutation and selection," Stochastic Processes and their Applications, Elsevier, vol. 77(2), pages 207-232, September.
    17. Vogl, Claus & Bergman, Juraj, 2015. "Inference of directional selection and mutation parameters assuming equilibrium," Theoretical Population Biology, Elsevier, vol. 106(C), pages 71-82.
    18. Stephen G. Walker & Matteo Ruggiero, 2007. "Construction and Stationary Distribution of the Fleming-Viot Process with Viability Selection," ICER Working Papers - Applied Mathematics Series 14-2007, ICER - International Centre for Economic Research.
    19. Burden, Conrad J. & Tang, Yurong, 2017. "Rate matrix estimation from site frequency data," Theoretical Population Biology, Elsevier, vol. 113(C), pages 23-33.
    20. Frank Hollander & Shubhamoy Nandan, 2022. "Spatially Inhomogeneous Populations with Seed-Banks: I. Duality, Existence and Clustering," Journal of Theoretical Probability, Springer, vol. 35(3), pages 1795-1841, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:thpobi:v:81:y:2012:i:2:p:144-157. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: https://www.journals.elsevier.com/intelligence .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.