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Looking down in the ancestral selection graph: A probabilistic approach to the common ancestor type distribution

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  • Lenz, Ute
  • Kluth, Sandra
  • Baake, Ellen
  • Wakolbinger, Anton

Abstract

In a (two-type) Wright–Fisher diffusion with directional selection and two-way mutation, let x denote today’s frequency of the beneficial type, and given x, let h(x) be the probability that, among all individuals of today’s population, the individual whose progeny will eventually take over in the population is of the beneficial type. Fearnhead (2002) and Taylor (2007) obtained a series representation for h(x). We develop a construction that contains elements of both the ancestral selection graph and the lookdown construction and includes pruning of certain lines upon mutation. Besides being interesting in its own right, this construction allows a transparent derivation of the series coefficients of h(x) and gives them a probabilistic meaning.

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  • Lenz, Ute & Kluth, Sandra & Baake, Ellen & Wakolbinger, Anton, 2015. "Looking down in the ancestral selection graph: A probabilistic approach to the common ancestor type distribution," Theoretical Population Biology, Elsevier, vol. 103(C), pages 27-37.
    • Handle: RePEc:eee:thpobi:v:103:y:2015:i:c:p:27-37
    DOI: 10.1016/j.tpb.2015.01.005
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    References listed on IDEAS

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    1. Pokalyuk, Cornelia & Pfaffelhuber, Peter, 2013. "The ancestral selection graph under strong directional selection," Theoretical Population Biology, Elsevier, vol. 87(C), pages 25-33.
    2. Mano, Shuhei, 2009. "Duality, ancestral and diffusion processes in models with selection," Theoretical Population Biology, Elsevier, vol. 75(2), pages 164-175.
    3. Etheridge, A.M. & Griffiths, R.C., 2009. "A coalescent dual process in a Moran model with genic selection," Theoretical Population Biology, Elsevier, vol. 75(4), pages 320-330.
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    Cited by:

    1. González Casanova, Adrián & Miró Pina, Verónica & Pardo, Juan Carlos, 2020. "The Wright–Fisher model with efficiency," Theoretical Population Biology, Elsevier, vol. 132(C), pages 33-46.
    2. Baake, E. & Esercito, L. & Hummel, S., 2023. "Lines of descent in a Moran model with frequency-dependent selection and mutation," Stochastic Processes and their Applications, Elsevier, vol. 160(C), pages 409-457.
    3. Cordero, Fernando, 2017. "Common ancestor type distribution: A Moran model and its deterministic limit," Stochastic Processes and their Applications, Elsevier, vol. 127(2), pages 590-621.
    4. Wirtz, Johannes & Wiehe, Thomas, 2019. "The Evolving Moran Genealogy," Theoretical Population Biology, Elsevier, vol. 130(C), pages 94-105.

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