IDEAS home Printed from https://ideas.repec.org/a/eee/rensus/v143y2021ics1364032121002008.html
   My bibliography  Save this article

Yeasts as microbial cell factories for sustainable production of biofuels

Author

Listed:
  • Liu, Zihe
  • Moradi, Hamideh
  • Shi, Shuobo
  • Darvishi, Farshad

Abstract

Sustainable production of biofuels has provided an attractive alternative to fossil fuels, which has relieved the concern regarding energy supply and global climate change. Currently, interest in metabolic engineering of yeasts as microbial cell factories for biofuel production, which varies from short-chain ethanol to long-chain fatty acid-derived molecules, is growing. The commercial production of new energy-dense biofuels using yeasts and new synthetic biology tools is now possible due to recent developments in metabolic engineering. Here, it is attempted to comprehensively and critically review the latest advances in metabolism-targeted strategies and the production of different types of biofuels using yeasts. Furthermore, the key challenges and perspectives have been discussed for improving yeast biorefineries for the production of biofuels, such as host compatibility of heterologous genes, substrate extension for alternative feedstocks, better tools for reprogramming cell metabolism, host robustness for tolerating or alleviating toxicity induced by end products, and new design principles with predictable behaviors for the constructed biological systems.

Suggested Citation

  • Liu, Zihe & Moradi, Hamideh & Shi, Shuobo & Darvishi, Farshad, 2021. "Yeasts as microbial cell factories for sustainable production of biofuels," Renewable and Sustainable Energy Reviews, Elsevier, vol. 143(C).
    • Handle: RePEc:eee:rensus:v:143:y:2021:i:c:s1364032121002008
    DOI: 10.1016/j.rser.2021.110907
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S1364032121002008
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.rser.2021.110907?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Aditiya, H.B. & Mahlia, T.M.I. & Chong, W.T. & Nur, Hadi & Sebayang, A.H., 2016. "Second generation bioethanol production: A critical review," Renewable and Sustainable Energy Reviews, Elsevier, vol. 66(C), pages 631-653.
    2. Farshad Darvishi Harzevili & Serge Hiligsmann, 2017. "Impressive potential of microorganisms to achieve the transition from fossil fuels to biofuels," ULB Institutional Repository 2013/271294, ULB -- Universite Libre de Bruxelles.
    3. Tao Yu & Yongjin J. Zhou & Leonie Wenning & Quanli Liu & Anastasia Krivoruchko & Verena Siewers & Jens Nielsen & Florian David, 2017. "Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals," Nature Communications, Nature, vol. 8(1), pages 1-11, August.
    4. Farshad Darvishi Harzevili & Serge Hiligsmann, 2017. "Microbial Fuels: Technologies and Applications," ULB Institutional Repository 2013/271293, ULB -- Universite Libre de Bruxelles.
    5. Codruta Ignea & Morten H. Raadam & Mohammed S. Motawia & Antonios M. Makris & Claudia E. Vickers & Sotirios C. Kampranis, 2019. "Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    6. Yongjin J. Zhou & Eduard J. Kerkhoven & Jens Nielsen, 2018. "Barriers and opportunities in bio-based production of hydrocarbons," Nature Energy, Nature, vol. 3(11), pages 925-935, November.
    7. Yongjin J. Zhou & Nicolaas A. Buijs & Zhiwei Zhu & Jiufu Qin & Verena Siewers & Jens Nielsen, 2016. "Production of fatty acid-derived oleochemicals and biofuels by synthetic yeast cell factories," Nature Communications, Nature, vol. 7(1), pages 1-9, September.
    8. Andreas Porse & Thea S. Schou & Christian Munck & Mostafa M. H. Ellabaan & Morten O. A. Sommer, 2018. "Biochemical mechanisms determine the functional compatibility of heterologous genes," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    9. Liu, Zhi-Hua & Le, Rosemary K. & Kosa, Matyas & Yang, Bin & Yuan, Joshua & Ragauskas, Arthur J., 2019. "Identifying and creating pathways to improve biological lignin valorization," Renewable and Sustainable Energy Reviews, Elsevier, vol. 105(C), pages 349-362.
    10. Tong Si & Ran Chao & Yuhao Min & Yuying Wu & Wen Ren & Huimin Zhao, 2017. "Automated multiplex genome-scale engineering in yeast," Nature Communications, Nature, vol. 8(1), pages 1-12, August.
    11. Pamela P. Peralta-Yahya & Mario Ouellet & Rossana Chan & Aindrila Mukhopadhyay & Jay D. Keasling & Taek Soon Lee, 2011. "Identification and microbial production of a terpene-based advanced biofuel," Nature Communications, Nature, vol. 2(1), pages 1-8, September.
    12. Yueping Zhang & Juan Wang & Zibai Wang & Yiming Zhang & Shuobo Shi & Jens Nielsen & Zihe Liu, 2019. "A gRNA-tRNA array for CRISPR-Cas9 based rapid multiplexed genome editing in Saccharomyces cerevisiae," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    13. Christopher, Lew P. & Hemanathan Kumar, & Zambare, Vasudeo P., 2014. "Enzymatic biodiesel: Challenges and opportunities," Applied Energy, Elsevier, vol. 119(C), pages 497-520.
    14. Xiaomei Lv & Fan Wang & Pingping Zhou & Lidan Ye & Wenping Xie & Haoming Xu & Hongwei Yu, 2016. "Dual regulation of cytoplasmic and mitochondrial acetyl-CoA utilization for improved isoprene production in Saccharomyces cerevisiae," Nature Communications, Nature, vol. 7(1), pages 1-12, November.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Dias, Bruna & Lopes, Marlene & Fernandes, Helena & Marques, Susana & Gírio, Francisco & Belo, Isabel, 2024. "Biomass and microbial lipids production by Yarrowia lipolytica W29 from eucalyptus bark hydrolysate," Renewable Energy, Elsevier, vol. 224(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Das, Manali & Patra, Pradipta & Ghosh, Amit, 2020. "Metabolic engineering for enhancing microbial biosynthesis of advanced biofuels," Renewable and Sustainable Energy Reviews, Elsevier, vol. 119(C).
    2. Dixit, Yatika & Yadav, Preeti & Sharma, Arun Kumar & Pandey, Poornima & Kuila, Arindam, 2023. "Multiplex genome editing to construct cellulase engineered Saccharomyces cerevisiae for ethanol production from cellulosic biomass," Renewable and Sustainable Energy Reviews, Elsevier, vol. 187(C).
    3. Qun Yue & Jie Meng & Yue Qiu & Miaomiao Yin & Liwen Zhang & Weiping Zhou & Zhiqiang An & Zihe Liu & Qipeng Yuan & Wentao Sun & Chun Li & Huimin Zhao & István Molnár & Yuquan Xu & Shuobo Shi, 2023. "A polycistronic system for multiplexed and precalibrated expression of multigene pathways in fungi," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    4. Shan Yang & Ruibing Chen & Xuan Cao & Guodong Wang & Yongjin J. Zhou, 2024. "De novo biosynthesis of the hops bioactive flavonoid xanthohumol in yeast," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    5. Zhang, Xiaolei & Yan, Song & Tyagi, Rajeshwar D. & Surampalli, RaoY. & Valéro, Jose R., 2014. "Wastewater sludge as raw material for microbial oils production," Applied Energy, Elsevier, vol. 135(C), pages 192-201.
    6. Liu, Ruo-Ying & Lan, Hai-Na & Liu, Zhi-Hua & Li, Bing-Zhi & Yuan, Ying-Jin, 2024. "Microbial valorization of lignin toward coumarins: Challenges and perspectives," Renewable and Sustainable Energy Reviews, Elsevier, vol. 191(C).
    7. Taghizadeh-Alisaraei, Ahmad & Motevali, Ali & Ghobadian, Barat, 2019. "Ethanol production from date wastes: Adapted technologies, challenges, and global potential," Renewable Energy, Elsevier, vol. 143(C), pages 1094-1110.
    8. Fernand, Francois & Israel, Alvaro & Skjermo, Jorunn & Wichard, Thomas & Timmermans, Klaas R. & Golberg, Alexander, 2017. "Offshore macroalgae biomass for bioenergy production: Environmental aspects, technological achievements and challenges," Renewable and Sustainable Energy Reviews, Elsevier, vol. 75(C), pages 35-45.
    9. Luigi Pari & Francesco Latterini & Walter Stefanoni, 2020. "Herbaceous Oil Crops, a Review on Mechanical Harvesting State of the Art," Agriculture, MDPI, vol. 10(8), pages 1-25, July.
    10. Zhiyong Cui & Yutao Zhong & Zhijie Sun & Zhennan Jiang & Jingyu Deng & Qian Wang & Jens Nielsen & Jin Hou & Qingsheng Qi, 2023. "Reconfiguration of the reductive TCA cycle enables high-level succinic acid production by Yarrowia lipolytica," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    11. Holmatov, B. & Hoekstra, A.Y. & Krol, M.S., 2019. "Land, water and carbon footprints of circular bioenergy production systems," Renewable and Sustainable Energy Reviews, Elsevier, vol. 111(C), pages 224-235.
    12. M. Tanvir Rahman & M. Kristian Koski & Joanna Panecka-Hofman & Werner Schmitz & Alexander J. Kastaniotis & Rebecca C. Wade & Rik K. Wierenga & J. Kalervo Hiltunen & Kaija J. Autio, 2023. "An engineered variant of MECR reductase reveals indispensability of long-chain acyl-ACPs for mitochondrial respiration," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    13. Kumar, R. & Strezov, V., 2021. "Thermochemical production of bio-oil: A review of downstream processing technologies for bio-oil upgrading, production of hydrogen and high value-added products," Renewable and Sustainable Energy Reviews, Elsevier, vol. 135(C).
    14. Murphy, Fionnuala & Devlin, Ger & Deverell, Rory & McDonnell, Kevin, 2014. "Potential to increase indigenous biodiesel production to help meet 2020 targets – An EU perspective with a focus on Ireland," Renewable and Sustainable Energy Reviews, Elsevier, vol. 35(C), pages 154-170.
    15. Carvalho, Ana Karine F. & Bento, Heitor B.S. & Izário Filho, Hélcio J. & de Castro, Heizir F., 2018. "Approaches to convert Mucor circinelloides lipid into biodiesel by enzymatic synthesis assisted by microwave irradiations," Renewable Energy, Elsevier, vol. 125(C), pages 747-754.
    16. Wentao Zheng & Yuxuan Wang & Jie Cui & Guangyao Guo & Yufeng Li & Jin Hou & Qiang Tu & Yulong Yin & Francis Stewart & Youming Zhang & Xiaoying Bian & Xue Wang, 2024. "ReaL-MGE is a tool for enhanced multiplex genome engineering and application to malonyl-CoA anabolism," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    17. Hui Liu & Pei Zhou & Mengya Qi & Liang Guo & Cong Gao & Guipeng Hu & Wei Song & Jing Wu & Xiulai Chen & Jian Chen & Wei Chen & Liming Liu, 2022. "Enhancing biofuels production by engineering the actin cytoskeleton in Saccharomyces cerevisiae," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    18. Codruta Ignea & Morten H. Raadam & Aikaterini Koutsaviti & Yong Zhao & Yao-Tao Duan & Maria Harizani & Karel Miettinen & Panagiota Georgantea & Mads Rosenfeldt & Sara E. Viejo-Ledesma & Mikael A. Pete, 2022. "Expanding the terpene biosynthetic code with non-canonical 16 carbon atom building blocks," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    19. Bingyin Peng & Lygie Esquirol & Zeyu Lu & Qianyi Shen & Li Chen Cheah & Christopher B. Howard & Colin Scott & Matt Trau & Geoff Dumsday & Claudia E. Vickers, 2022. "An in vivo gene amplification system for high level expression in Saccharomyces cerevisiae," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    20. William M. Shaw & Lucie Studená & Kyler Roy & Piotr Hapeta & Nicholas S. McCarty & Alicia E. Graham & Tom Ellis & Rodrigo Ledesma-Amaro, 2022. "Inducible expression of large gRNA arrays for multiplexed CRISPRai applications," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:rensus:v:143:y:2021:i:c:s1364032121002008. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/wps/find/journaldescription.cws_home/600126/description#description .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.