IDEAS home Printed from https://ideas.repec.org/a/wsi/jikmxx/v18y2019i01ns0219649219500011.html
   My bibliography  Save this article

Visualisation and Modelling of High-Dimensional Cancerous Gene Expression Dataset

Author

Listed:
  • Abhishek Bhola

    (Department of Computer Science and Engineering, Punjab Engineering College (Deemed to be University), Sector 12, Chandigarh 160012, India)

  • Shailendra Singh

    (Department of Computer Science and Engineering, Punjab Engineering College (Deemed to be University), Sector 12, Chandigarh 160012, India)

Abstract

The increase in the number of dimensions of cancerous gene expression dataset causes an increase in complexity, misinterpretation and decrease in the visualisation of the particular dataset for further analysis. Therefore, dimensionality reduction, visualisation and modelling tasks of these dataset become challenging. In this paper, a framework is developed which helps to understand, visualise and model high-dimensional cancerous gene expression dataset into lower dimensions which may be helpful in revealing cancer mechanism and diagnosis. Initially, cancerous gene expression datasets are preprocessed to make them complete, precise and efficient; and principal component analysis is applied for dimensionality reduction and visualisation purpose. The regression is used to model the cancerous gene expression dataset so that type of association (linear or nonlinear) and directions between gene profiles may be estimated. To assess the performance of the developed framework, three different types of cancerous gene expression datasets are taken namely: breast (GEO Acc. No. GDS5076), lung (GEO Acc. No. GDS5040) and prostate (GEO Acc. No. GDS5072) which are publicly available. To validate the results of the regression the cross-validation method is used. The results revealed that a linear approach is to be used for prostate cancer dataset and nonlinear approach for breast and lung cancer datasets in finding an association between gene pairs.

Suggested Citation

  • Abhishek Bhola & Shailendra Singh, 2019. "Visualisation and Modelling of High-Dimensional Cancerous Gene Expression Dataset," Journal of Information & Knowledge Management (JIKM), World Scientific Publishing Co. Pte. Ltd., vol. 18(01), pages 1-22, March.
  • Handle: RePEc:wsi:jikmxx:v:18:y:2019:i:01:n:s0219649219500011
    DOI: 10.1142/S0219649219500011
    as

    Download full text from publisher

    File URL: http://www.worldscientific.com/doi/abs/10.1142/S0219649219500011
    Download Restriction: Access to full text is restricted to subscribers

    File URL: https://libkey.io/10.1142/S0219649219500011?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Dai Jian J & Lieu Linh & Rocke David, 2006. "Dimension Reduction for Classification with Gene Expression Microarray Data," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 5(1), pages 1-21, February.
    2. Ming Yuan & Yi Lin, 2006. "Model selection and estimation in regression with grouped variables," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 68(1), pages 49-67, February.
    3. Witten, Daniela M. & Tibshirani, Robert, 2010. "A Framework for Feature Selection in Clustering," Journal of the American Statistical Association, American Statistical Association, vol. 105(490), pages 713-726.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Dong Liu & Changwei Zhao & Yong He & Lei Liu & Ying Guo & Xinsheng Zhang, 2023. "Simultaneous cluster structure learning and estimation of heterogeneous graphs for matrix‐variate fMRI data," Biometrics, The International Biometric Society, vol. 79(3), pages 2246-2259, September.
    2. Tutz, Gerhard & Pößnecker, Wolfgang & Uhlmann, Lorenz, 2015. "Variable selection in general multinomial logit models," Computational Statistics & Data Analysis, Elsevier, vol. 82(C), pages 207-222.
    3. Guillaume Sagnol & Edouard Pauwels, 2019. "An unexpected connection between Bayes A-optimal designs and the group lasso," Statistical Papers, Springer, vol. 60(2), pages 565-584, April.
    4. Bakalli, Gaetan & Guerrier, Stéphane & Scaillet, Olivier, 2023. "A penalized two-pass regression to predict stock returns with time-varying risk premia," Journal of Econometrics, Elsevier, vol. 237(2).
    5. Shuichi Kawano, 2014. "Selection of tuning parameters in bridge regression models via Bayesian information criterion," Statistical Papers, Springer, vol. 55(4), pages 1207-1223, November.
    6. Wongsa-art, Pipat & Kim, Namhyun & Xia, Yingcun & Moscone, Francesco, 2024. "Varying coefficient panel data models and methods under correlated error components: Application to disparities in mental health services in England," Regional Science and Urban Economics, Elsevier, vol. 106(C).
    7. Dong, C. & Li, S., 2021. "Specification Lasso and an Application in Financial Markets," Cambridge Working Papers in Economics 2139, Faculty of Economics, University of Cambridge.
    8. Lam, Clifford, 2008. "Estimation of large precision matrices through block penalization," LSE Research Online Documents on Economics 31543, London School of Economics and Political Science, LSE Library.
    9. Weiyang Ding & Michael K. Ng & Wenxing Zhang, 2024. "A generalized alternating direction implicit method for consensus optimization: application to distributed sparse logistic regression," Journal of Global Optimization, Springer, vol. 90(3), pages 727-753, November.
    10. Gregory Vaughan & Robert Aseltine & Kun Chen & Jun Yan, 2017. "Stagewise generalized estimating equations with grouped variables," Biometrics, The International Biometric Society, vol. 73(4), pages 1332-1342, December.
    11. Yaeji Lim & Hee-Seok Oh & Ying Kuen Cheung, 2019. "Multiscale Clustering for Functional Data," Journal of Classification, Springer;The Classification Society, vol. 36(2), pages 368-391, July.
    12. Pradeep Ravikumar & John Lafferty & Han Liu & Larry Wasserman, 2009. "Sparse additive models," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 71(5), pages 1009-1030, November.
    13. Yujia Li & Xiangrui Zeng & Chien‐Wei Lin & George C. Tseng, 2022. "Simultaneous estimation of cluster number and feature sparsity in high‐dimensional cluster analysis," Biometrics, The International Biometric Society, vol. 78(2), pages 574-585, June.
    14. Yucheng Yang & Zhong Zheng & Weinan E, 2020. "Interpretable Neural Networks for Panel Data Analysis in Economics," Papers 2010.05311, arXiv.org, revised Nov 2020.
    15. Madeleine Cule & Richard Samworth & Michael Stewart, 2010. "Maximum likelihood estimation of a multi‐dimensional log‐concave density," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 72(5), pages 545-607, November.
    16. Toshio Honda, 2021. "The de-biased group Lasso estimation for varying coefficient models," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 73(1), pages 3-29, February.
    17. Bilin Zeng & Xuerong Meggie Wen & Lixing Zhu, 2017. "A link-free sparse group variable selection method for single-index model," Journal of Applied Statistics, Taylor & Francis Journals, vol. 44(13), pages 2388-2400, October.
    18. Jeffrey Andrews & Paul McNicholas, 2014. "Variable Selection for Clustering and Classification," Journal of Classification, Springer;The Classification Society, vol. 31(2), pages 136-153, July.
    19. Xu Cheng & Zhipeng Liao & Frank Schorfheide, 2016. "Shrinkage Estimation of High-Dimensional Factor Models with Structural Instabilities," The Review of Economic Studies, Review of Economic Studies Ltd, vol. 83(4), pages 1511-1543.
    20. Capanu, Marinela & Giurcanu, Mihai & Begg, Colin B. & Gönen, Mithat, 2023. "Subsampling based variable selection for generalized linear models," Computational Statistics & Data Analysis, Elsevier, vol. 184(C).

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:wsi:jikmxx:v:18:y:2019:i:01:n:s0219649219500011. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Tai Tone Lim (email available below). General contact details of provider: http://www.worldscinet.com/jikm/jikm.shtml .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.