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Dermal Uptake of 18 Dilute Aqueous Chemicals: In Vivo Disappearance‐Method Measures Greatly Exceed In Vitro‐Based Predictions

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  • Kenneth T. Bogen

Abstract

Average rates of total dermal uptake (Kup) from short‐term (e.g., bathing) contact with dilute aqueous organic chemicals (DAOCs) are typically estimated from steady‐state in vitro diffusion‐cell measures of chemical permeability (Kp) through skin into receptor solution. Widely used (“PCR‐vitro”) methods estimate Kup by applying diffusion theory to increase Kp predictions made by a physico‐chemical regression (PCR) model that was fit to a large set of Kp measures. Here, Kup predictions for 18 DAOCs made by three PCR‐vitro models (EPA, NIOSH, and MH) were compared to previous in vivo measures obtained by methods unlikely to underestimate Kup. A new PCR model fit to all 18 measures is accurate to within approximately threefold (r = 0.91, p 0.63) all tend to underestimate the Kup measures by mean factors (UF, and p value for testing UF = 1) of 10 (EPA, p 0.05), so vapor pressure appears not to explain the significant in vivo/PCR‐vitro discrepancy. Until this discrepancy is explained, careful in vivo measures of Kup should be obtained for more chemicals, the expanded in vivo database should be compared to in vitro‐based predictions, and in vivo data should be considered in assessing aqueous dermal exposure and its uncertainty.

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  • Kenneth T. Bogen, 2013. "Dermal Uptake of 18 Dilute Aqueous Chemicals: In Vivo Disappearance‐Method Measures Greatly Exceed In Vitro‐Based Predictions," Risk Analysis, John Wiley & Sons, vol. 33(7), pages 1334-1352, July.
    • Handle: RePEc:wly:riskan:v:33:y:2013:i:7:p:1334-1352
    DOI: 10.1111/j.1539-6924.2012.01901.x
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    References listed on IDEAS

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    1. Mohammad S. Islam & Luhua Zhao & James N. McDougal & Gordon L. Flynn, 1995. "Uptake of Chloroform by Skin During Short Exposures to Contaminated Water," Risk Analysis, John Wiley & Sons, vol. 15(3), pages 343-352, June.
    2. Thomas E. McKone & Robert A. Howd, 1992. "Estimating Dermal Uptake of Nonionic Organic Chemicals from Water and Soil: I. Unified Fugacity‐Based Models for Risk Assessments," Risk Analysis, John Wiley & Sons, vol. 12(4), pages 543-557, December.
    3. J. P. Royston, 1982. "Expected Normal Order Statistics (Exact and Approximate)," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 31(2), pages 161-165, June.
    4. Wan K. Jo & Clifford P. Weisel & Paul J. Lioy, 1990. "Chloroform Exposure and the Health Risk Associated with Multiple Uses of Chlorinated Tap Water," Risk Analysis, John Wiley & Sons, vol. 10(4), pages 581-585, December.
    5. Wan K. Jo & Clifford P. Weisel & Paul J. Lioy, 1990. "Routes of Chloroform Exposure and Body Burden from Showering with Chlorinated Tap Water," Risk Analysis, John Wiley & Sons, vol. 10(4), pages 575-580, December.
    6. Robert L. Chinery & A. Kevin Gleason, 1993. "A Compartmental Model for the Prediction of Breath Concentration and Absorbed Dose of Chloroform After Exposure While Showering," Risk Analysis, John Wiley & Sons, vol. 13(1), pages 51-62, February.
    7. Mohammad S. Islam & Luhua Zhao & Joseph Zhou & Lilly Dong & James N. McDougal & Gordon L. Flynn, 1996. "Systemic Uptake and Clearance of Chloroform by Hairless Rats Following Dermal Exposure. I. Brief Exposure to Aqueous Solutions," Risk Analysis, John Wiley & Sons, vol. 16(3), pages 349-357, June.
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    1. Kenneth T. Bogen & Patrick J. Sheehan, 2014. "Dermal Versus Total Uptake of Benzene from Mineral Spirits Solvent During Parts Washing," Risk Analysis, John Wiley & Sons, vol. 34(7), pages 1336-1358, July.

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