IDEAS home Printed from https://ideas.repec.org/a/wly/riskan/v12y1992i4p543-557.html
   My bibliography  Save this article

Estimating Dermal Uptake of Nonionic Organic Chemicals from Water and Soil: I. Unified Fugacity‐Based Models for Risk Assessments

Author

Listed:
  • Thomas E. McKone
  • Robert A. Howd

Abstract

Contamination of water and soil that might eventually contact human skin makes it imperative to include the dermal uptake route in efforts to assess potential environmental health risks. Direct measurements of dermal uptake from either water or soil are only available for a small number of the thousands of chemicals likely to be found in the environment. We propose here a mass‐transfer model for estimating skin permeability and dermal uptake for organic chemicals that contaminate soil and water. Statistical relationships between measured permeabilities and chemical properties reveal that permeability varies primarily with the octanol‐water partition coefficient (Kow)and secondarily with the molecular weight. From these results, we derive a fugacity‐based model for skin permeability that addresses the inherent permeability of the skin, the interaction of the skin with the environmental medium on skin (water or soil), and retains a relatively simple algebraic form. Model predictions are compared to measured human skin permeabilities for some 50 compounds in water and four compounds in soil. The model is adjusted to account for dermal uptake during both short‐term (10‐20 min)and long‐term (several hour)exposures. This model is recommended for compounds with molecular weight less than or equal to 280 g.

Suggested Citation

  • Thomas E. McKone & Robert A. Howd, 1992. "Estimating Dermal Uptake of Nonionic Organic Chemicals from Water and Soil: I. Unified Fugacity‐Based Models for Risk Assessments," Risk Analysis, John Wiley & Sons, vol. 12(4), pages 543-557, December.
    • Handle: RePEc:wly:riskan:v:12:y:1992:i:4:p:543-557
    DOI: 10.1111/j.1539-6924.1992.tb00711.x
    as

    Download full text from publisher

    File URL: https://doi.org/10.1111/j.1539-6924.1992.tb00711.x
    Download Restriction: no
    File URL: https://libkey.io/10.1111/j.1539-6924.1992.tb00711.x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Thomas E. McKone, 1990. "Dermal Uptake of Organic Chemicals from a Soil Matrix," Risk Analysis, John Wiley & Sons, vol. 10(3), pages 407-419, September.
    2. Wan K. Jo & Clifford P. Weisel & Paul J. Lioy, 1990. "Routes of Chloroform Exposure and Body Burden from Showering with Chlorinated Tap Water," Risk Analysis, John Wiley & Sons, vol. 10(4), pages 575-580, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Kenneth T. Bogen, 2013. "Dermal Uptake of 18 Dilute Aqueous Chemicals: In Vivo Disappearance‐Method Measures Greatly Exceed In Vitro‐Based Predictions," Risk Analysis, John Wiley & Sons, vol. 33(7), pages 1334-1352, July.
    2. Michael R. Adams & Cynthia A. Hanna & Janet A. Mayernik & William M. Mendez, 1994. "Probabilistic Health Risk Assessment for Exposures to Estuary Sediments and Biota Contaminated with Polychlorinated Biphenyls, Polychlorinated Terphenyls and Other Toxic Substances," Risk Analysis, John Wiley & Sons, vol. 14(4), pages 577-594, August.
    3. Jaspreet S. Gujral & Deborah M. Proctor & Steave H. Su & Joseph M. Fedoruk, 2011. "Water Adherence Factors for Human Skin," Risk Analysis, John Wiley & Sons, vol. 31(8), pages 1271-1280, August.
    4. Jacob Krüse & Christel W. E. Verberk, 2008. "Modelling of systemic uptake of agrochemicals after dermal exposure; effects of formulation, application and exposure scenarios," Environment Systems and Decisions, Springer, vol. 28(1), pages 57-65, March.
    5. H. Frederick Frasch, 2002. "A Random Walk Model of Skin Permeation," Risk Analysis, John Wiley & Sons, vol. 22(2), pages 265-276, April.
    6. W. J. Riley & T. E. McKone & E. A. Cohen Hubal, 2004. "Estimating Contaminant Dose for Intermittent Dermal Contact: Model Development, Testing, and Application," Risk Analysis, John Wiley & Sons, vol. 24(1), pages 73-85, February.
    7. Mark P. van Veen, 1996. "A General Model for Exposure and Uptake from Consumer Products," Risk Analysis, John Wiley & Sons, vol. 16(3), pages 331-338, June.
    8. Mohammad S. Islam & Luhua Zhao & Joseph Zhou & Lilly Dong & James N. McDougal & Gordon L. Flynn, 1996. "Systemic Uptake and Clearance of Chloroform by Hairless Rats Following Dermal Exposure. I. Brief Exposure to Aqueous Solutions," Risk Analysis, John Wiley & Sons, vol. 16(3), pages 349-357, June.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Wan K. Jo & Clifford P. Weisel & Paul J. Lioy, 1990. "Chloroform Exposure and the Health Risk Associated with Multiple Uses of Chlorinated Tap Water," Risk Analysis, John Wiley & Sons, vol. 10(4), pages 581-585, December.
    2. Mathieu Valcke & Kannan Krishnan, 2010. "An Assessment of the Interindividual Variability of Internal Dosimetry during Multi-Route Exposure to Drinking Water Contaminants," IJERPH, MDPI, vol. 7(11), pages 1-21, November.
    3. Kimberly M. Thompson & David E. Burmaster & Edmund A.C. Crouch3, 1992. "Monte Carlo Techniques for Quantitative Uncertainty Analysis in Public Health Risk Assessments," Risk Analysis, John Wiley & Sons, vol. 12(1), pages 53-63, March.
    4. David E. Burmaster & Nancy Irwin Maxwell, 1991. "Time‐ and Loading‐Dependence in the McKone Model for Dermal Uptake of Organic Chemicals from a Soil Matrix," Risk Analysis, John Wiley & Sons, vol. 11(3), pages 491-497, September.
    5. Kenneth T. Bogen, 2013. "Dermal Uptake of 18 Dilute Aqueous Chemicals: In Vivo Disappearance‐Method Measures Greatly Exceed In Vitro‐Based Predictions," Risk Analysis, John Wiley & Sons, vol. 33(7), pages 1334-1352, July.
    6. Mohammad S. Islam & Luhua Zhao & James N. McDougal & Gordon L. Flynn, 1995. "Uptake of Chloroform by Skin During Short Exposures to Contaminated Water," Risk Analysis, John Wiley & Sons, vol. 15(3), pages 343-352, June.
    7. Brent Finley & Dennis Paustenbach, 1994. "The Benefits of Probabilistic Exposure Assessment: Three Case Studies Involving Contaminated Air, Water, and Soil," Risk Analysis, John Wiley & Sons, vol. 14(1), pages 53-73, February.
    8. Thomas E. McKone, 1991. "Human Exposure to Chemicals from Multiple Media and through Multiple Pathways: Research Overview and Comments," Risk Analysis, John Wiley & Sons, vol. 11(1), pages 5-10, March.
    9. Brent L. Finley & Paul K. Scott & Douglas A. Mayhall, 1994. "Development of a Standard Soil‐to‐Skin Adherence Probability Density Function for Use in Monte Carlo Analyses of Dermal Exposure," Risk Analysis, John Wiley & Sons, vol. 14(4), pages 555-569, August.
    10. Tine Bizjak & Marco Capodiferro & Deepika Deepika & Öykü Dinçkol & Vazha Dzhedzheia & Lorena Lopez-Suarez & Ioannis Petridis & Agneta A. Runkel & Dayna R. Schultz & Branko Kontić, 2022. "Human Biomonitoring Data in Health Risk Assessments Published in Peer-Reviewed Journals between 2016 and 2021: Confronting Reality after a Preliminary Review," IJERPH, MDPI, vol. 19(6), pages 1-18, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:wly:riskan:v:12:y:1992:i:4:p:543-557. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: https://doi.org/10.1111/(ISSN)1539-6924 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.