IDEAS home Printed from https://ideas.repec.org/a/taf/jnlasa/v109y2014i507p955-966.html
   My bibliography  Save this article

Multivariate Analysis of Longitudinal Ordinal Data With Mixed Effects Models, With Application to Clinical Outcomes in Osteoarthritis

Author

Listed:
  • Celine Marielle Laffont
  • Marc Vandemeulebroecke
  • Didier Concordet

Abstract

Our objective was to evaluate the efficacy of robenacoxib in osteoarthritic dogs using four ordinal responses measured repeatedly over time. We propose a multivariate probit mixed effects model to describe the joint evolution of endpoints and to evidence the intrinsic correlations between responses that are not due to treatment effect. Maximum likelihood computation is intractable within reasonable time frames. We therefore use a pairwise modeling approach in combination with a stochastic EM algorithm. Multidimensional ordinal responses with longitudinal measurements are a common feature in clinical trials. However, the standard methods for data analysis use unidimensional models, resulting in a loss of information. Our methodology provides substantially greater insight than these methods for the evaluation of treatment effects and shows a good performance at low computational cost. We thus believe that it could be used in routine practice to optimize the evaluation of treatment efficacy.

Suggested Citation

  • Celine Marielle Laffont & Marc Vandemeulebroecke & Didier Concordet, 2014. "Multivariate Analysis of Longitudinal Ordinal Data With Mixed Effects Models, With Application to Clinical Outcomes in Osteoarthritis," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 109(507), pages 955-966, September.
    • Handle: RePEc:taf:jnlasa:v:109:y:2014:i:507:p:955-966
    DOI: 10.1080/01621459.2014.917977
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/01621459.2014.917977
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/01621459.2014.917977?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Dunson, David B., 2003. "Dynamic Latent Trait Models for Multidimensional Longitudinal Data," Journal of the American Statistical Association, American Statistical Association, vol. 98, pages 555-563, January.
    2. Sik-Yum Lee & Xin-Yuan Song, 2004. "Maximum Likelihood Analysis of a General Latent Variable Model with Hierarchically Mixed Data," Biometrics, The International Biometric Society, vol. 60(3), pages 624-636, September.
    3. Ivy Liu & Alan Agresti, 2005. "The analysis of ordered categorical data: An overview and a survey of recent developments," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 14(1), pages 1-73, June.
    4. Li, Yonghai & Schafer, Daniel W., 2008. "Likelihood analysis of the multivariate ordinal probit regression model for repeated ordinal responses," Computational Statistics & Data Analysis, Elsevier, vol. 52(7), pages 3474-3492, March.
    5. J. G. Booth & J. P. Hobert, 1999. "Maximizing generalized linear mixed model likelihoods with an automated Monte Carlo EM algorithm," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 61(1), pages 265-285.
    6. Thomas R. Ten Have & Alfredo Morabia, 1999. "Mixed Effects Models with Bivariate and Univariate Association Parameters for Longitudinal Bivariate Binary Response Data," Biometrics, The International Biometric Society, vol. 55(1), pages 85-93, March.
    7. Katsikatsou, Myrsini & Moustaki, Irini & Yang-Wallentin, Fan & Jöreskog, Karl G., 2012. "Pairwise likelihood estimation for factor analysis models with ordinal data," LSE Research Online Documents on Economics 43182, London School of Economics and Political Science, LSE Library.
    8. Bahjat F. Qaqish & Anastasia Ivanova, 2006. "Multivariate logistic models," Biometrika, Biometrika Trust, vol. 93(4), pages 1011-1017, December.
    9. Steffen Fieuws & Geert Verbeke, 2006. "Pairwise Fitting of Mixed Models for the Joint Modeling of Multivariate Longitudinal Profiles," Biometrics, The International Biometric Society, vol. 62(2), pages 424-431, June.
    10. J.‐Q. Shi & S.‐Y. Lee, 2000. "Latent variable models with mixed continuous and polytomous data," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 62(1), pages 77-87.
    11. Steffen Fieuws & Geert Verbeke & Filip Boen & Christophe Delecluse, 2006. "High dimensional multivariate mixed models for binary questionnaire data," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 55(4), pages 449-460, August.
    12. Katsikatsou, Myrsini & Moustaki, Irini & Yang-Wallentin, Fan & Jöreskog, Karl G., 2012. "Pairwise likelihood estimation for factor analysis models with ordinal data," Computational Statistics & Data Analysis, Elsevier, vol. 56(12), pages 4243-4258.
    13. Mary Dupuis Sammel & Louise M. Ryan & Julie M. Legler, 1997. "Latent Variable Models for Mixed Discrete and Continuous Outcomes," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 59(3), pages 667-678.
    14. Kuhn, E. & Lavielle, M., 2005. "Maximum likelihood estimation in nonlinear mixed effects models," Computational Statistics & Data Analysis, Elsevier, vol. 49(4), pages 1020-1038, June.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yu-Zhu Tian & Man-Lai Tang & Wai-Sum Chan & Mao-Zai Tian, 2021. "Bayesian bridge-randomized penalized quantile regression for ordinal longitudinal data, with application to firm’s bond ratings," Computational Statistics, Springer, vol. 36(2), pages 1289-1319, June.
    2. Dipankar Bandyopadhyay & Antonio Canale, 2016. "Non-parametric spatial models for clustered ordered periodontal data," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 65(4), pages 619-640, August.
    3. Chu, Amanda M.Y. & Omori, Yasuhiro & So, Hing-yu & So, Mike K.P., 2023. "A Multivariate Randomized Response Model for Sensitive Binary Data," Econometrics and Statistics, Elsevier, vol. 27(C), pages 16-35.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Sik-Yum Lee & Xin-Yuan Song, 2007. "A Unified Maximum Likelihood Approach for Analyzing Structural Equation Models With Missing Nonstandard Data," Sociological Methods & Research, , vol. 35(3), pages 352-381, February.
    2. Zhang, Q. & Ip, E.H., 2014. "Variable assessment in latent class models," Computational Statistics & Data Analysis, Elsevier, vol. 77(C), pages 146-156.
    3. Alexander Robitzsch, 2024. "A Comparison of Limited Information Estimation Methods for the Two-Parameter Normal-Ogive Model with Locally Dependent Items," Stats, MDPI, vol. 7(3), pages 1-16, June.
    4. Papageorgiou, Ioulia & Moustaki, Irini, 2019. "Sampling of pairs in pairwise likelihood estimation for latent variable models with categorical observed variables," LSE Research Online Documents on Economics 87592, London School of Economics and Political Science, LSE Library.
    5. Myrsini Katsikatsou & Irini Moustaki, 2016. "Pairwise Likelihood Ratio Tests and Model Selection Criteria for Structural Equation Models with Ordinal Variables," Psychometrika, Springer;The Psychometric Society, vol. 81(4), pages 1046-1068, December.
    6. Emilio Augusto Coelho-Barros & Jorge Alberto Achcar & Josmar Mazucheli, 2010. "Longitudinal Poisson modeling: an application for CD4 counting in HIV-infected patients," Journal of Applied Statistics, Taylor & Francis Journals, vol. 37(5), pages 865-880.
    7. Jeonghye Choi & David R. Bell & Leonard M. Lodish, 2012. "Traditional and IS-Enabled Customer Acquisition on the Internet," Management Science, INFORMS, vol. 58(4), pages 754-769, April.
    8. Zhang, Xiao & Boscardin, W. John & Belin, Thomas R. & Wan, Xiaohai & He, Yulei & Zhang, Kui, 2015. "A Bayesian method for analyzing combinations of continuous, ordinal, and nominal categorical data with missing values," Journal of Multivariate Analysis, Elsevier, vol. 135(C), pages 43-58.
    9. Margaux Delporte & Steffen Fieuws & Geert Molenberghs & Geert Verbeke & Simeon Situma Wanyama & Elpis Hatziagorou & Christiane De Boeck, 2022. "A joint normal‐binary (probit) model," International Statistical Review, International Statistical Institute, vol. 90(S1), pages 37-51, December.
    10. An, Xinming & Bentler, Peter M., 2012. "Efficient direct sampling MCEM algorithm for latent variable models with binary responses," Computational Statistics & Data Analysis, Elsevier, vol. 56(2), pages 231-244.
    11. Alexander Robitzsch, 2021. "A Comprehensive Simulation Study of Estimation Methods for the Rasch Model," Stats, MDPI, vol. 4(4), pages 1-23, October.
    12. Katsikatsou, Myrsini & Moustaki, Irini & Md Jamil, Haziq, 2022. "Pairwise likelihood estimation for confirmatory factor analysis models with categorical variables and data that are missing at random," LSE Research Online Documents on Economics 108933, London School of Economics and Political Science, LSE Library.
    13. Øystein Sørensen & Anders M. Fjell & Kristine B. Walhovd, 2023. "Longitudinal Modeling of Age-Dependent Latent Traits with Generalized Additive Latent and Mixed Models," Psychometrika, Springer;The Psychometric Society, vol. 88(2), pages 456-486, June.
    14. Battauz, Michela & Vidoni, Paolo, 2022. "A likelihood-based boosting algorithm for factor analysis models with binary data," Computational Statistics & Data Analysis, Elsevier, vol. 168(C).
    15. Zachary F. Fisher & Kenneth A. Bollen, 2020. "An Instrumental Variable Estimator for Mixed Indicators: Analytic Derivatives and Alternative Parameterizations," Psychometrika, Springer;The Psychometric Society, vol. 85(3), pages 660-683, September.
    16. Trevezas, S. & Malefaki, S. & Cournède, P.-H., 2014. "Parameter estimation via stochastic variants of the ECM algorithm with applications to plant growth modeling," Computational Statistics & Data Analysis, Elsevier, vol. 78(C), pages 82-99.
    17. Jerzy Grobelny & Rafal Michalski & Gerhard-Wilhelm Weber, 2021. "Modeling human thinking about similarities by neuromatrices in the perspective of fuzzy logic," WORking papers in Management Science (WORMS) WORMS/21/09, Department of Operations Research and Business Intelligence, Wroclaw University of Science and Technology.
    18. Anna Ivanova & Geert Molenberghs & Geert Verbeke, 2017. "Mechanism for missing data incorporated in joint modelling of ordinal responses," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 66(5), pages 1049-1064, November.
    19. Geminiani, Elena & Marra, Giampiero & Moustaki, Irini, 2021. "Single and multiple-group penalized factor analysis: a trust-region algorithm approach with integrated automatic multiple tuning parameter selection," LSE Research Online Documents on Economics 108873, London School of Economics and Political Science, LSE Library.
    20. Zhang, Haoran & Chen, Yunxiao & Li, Xiaoou, 2020. "A note on exploratory item factor analysis by singular value decomposition," LSE Research Online Documents on Economics 104166, London School of Economics and Political Science, LSE Library.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:jnlasa:v:109:y:2014:i:507:p:955-966. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/UASA20 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.