IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0234833.html
   My bibliography  Save this article

Factors influencing precision medicine knowledge and attitudes

Author

Listed:
  • Rohini Chakravarthy
  • Sarah C Stallings
  • Michael Williams
  • Megan Hollister
  • Mario Davidson
  • Juan Canedo
  • Consuelo H Wilkins

Abstract

Precision medicine holds great promise for improving health and reducing health disparities that can be most fully realized by advancing diversity and inclusion in research participants. Without engaging underrepresented groups, precision medicine could not only fail to achieve its promise but also further exacerbate the health disparities already burdening the most vulnerable. Yet underrepresentation by people of non-European ancestry continues in precision medicine research and there are disparities across racial groups in the uptake of precision medicine applications and services. Studies have explored possible explanations for population differences in precision medicine participation, but full appreciation of the factors involved is still developing. To better inform the potential for addressing health disparities through PM, we assessed the relationship of precision medicine knowledge and trust in biomedical research with sociodemographic variables. Using a series of linear regression models applied to survey data collected in a diverse sample, we analyzed variation in both precision medicine knowledge and trust in biomedical research with socioeconomic factors as a way to understand the range of precision medicine knowledge (PMK) in a broadly representative group and its relationship to trust in research and demographic characteristics. Our results demonstrate that identifying as Black, while significantly PMK, explains only 1.5% of the PMK variance in unadjusted models and 7% of overall variance in models adjusted for meaningful covariates such as age, marital status, employment, and education. We also found a positive association between PMK and trust in biomedical research. These results indicate that race is a factor affecting PMK, even after accounting for differences in sociodemographic variables. Additional work is needed, however, to identify other factors contributing to variation in PMK as we work to increase diversity and inclusion in precision medicine applications.

Suggested Citation

  • Rohini Chakravarthy & Sarah C Stallings & Michael Williams & Megan Hollister & Mario Davidson & Juan Canedo & Consuelo H Wilkins, 2020. "Factors influencing precision medicine knowledge and attitudes," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-14, November.
    • Handle: RePEc:plo:pone00:0234833
    DOI: 10.1371/journal.pone.0234833
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234833
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0234833&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0234833?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Samuel J. Aronson & Heidi L. Rehm, 2015. "Building the foundation for genomics in precision medicine," Nature, Nature, vol. 526(7573), pages 336-342, October.
    2. Kasisomayajula Viswanath & Leland K Ackerson, 2011. "Race, Ethnicity, Language, Social Class, and Health Communication Inequalities: A Nationally-Representative Cross-Sectional Study," PLOS ONE, Public Library of Science, vol. 6(1), pages 1-8, January.
    3. Alice B. Popejoy & Stephanie M. Fullerton, 2016. "Genomics is failing on diversity," Nature, Nature, vol. 538(7624), pages 161-164, October.
    4. George, S. & Duran, N. & Norris, K., 2014. "A systematic review of barriers and facilitators to minority research participation among African Americans, Latinos, Asian Americans, and Pacific Islanders," American Journal of Public Health, American Public Health Association, vol. 104(2), pages 16-31.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Wei Fu & Shin-Yi Chou & Li-San Wang, 2022. "NIH Grant Expansion, Ancestral Diversity and Scientific Discovery in Genomics Research," NBER Working Papers 30155, National Bureau of Economic Research, Inc.
    2. Brandy M Mapes & Christopher S Foster & Sheila V Kusnoor & Marcia I Epelbaum & Mona AuYoung & Gwynne Jenkins & Maria Lopez-Class & Dara Richardson-Heron & Ahmed Elmi & Karl Surkan & Robert M Cronin & , 2020. "Diversity and inclusion for the All of Us research program: A scoping review," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-14, July.
    3. Amelia S Knopf & Peter Krombach & Amy J Katz & Rebecca Baker & Gregory Zimet, 2021. "Measuring research mistrust in adolescents and adults: Validity and reliability of an adapted version of the Group-Based Medical Mistrust Scale," PLOS ONE, Public Library of Science, vol. 16(1), pages 1-9, January.
    4. Michel S. Naslavsky & Marilia O. Scliar & Guilherme L. Yamamoto & Jaqueline Yu Ting Wang & Stepanka Zverinova & Tatiana Karp & Kelly Nunes & José Ricardo Magliocco Ceroni & Diego Lima Carvalho & Carlo, 2022. "Whole-genome sequencing of 1,171 elderly admixed individuals from Brazil," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    5. Bruce, Marta M. & Ulrich, Connie M. & Webster, Jessica & Richmond, Therese S., 2022. "Injured black men's perceptions of the recovery environment," Social Science & Medicine, Elsevier, vol. 292(C).
    6. Charlene S. Aaron, 2016. "Recruitment of African Americans With Type 2 Diabetes Who Care For Persons With Dementia," Clinical Nursing Research, , vol. 25(1), pages 3-8, February.
    7. Stephen Amoah & Ruth Ennin & Karen Sagoe & Astrid Steinbrecher & Tobias Pischon & Frank P. Mockenhaupt & Ina Danquah, 2021. "Feasibility of a Culturally Adapted Dietary Weight-Loss Intervention among Ghanaian Migrants in Berlin, Germany: The ADAPT Study," IJERPH, MDPI, vol. 18(2), pages 1-13, January.
    8. Margarita Echeverri & David Anderson & Anna María Nápoles & Jacqueline M. Haas & Marc E. Johnson & Friar Sergio A. Serrano, 2018. "Cancer Health Literacy and Willingness to Participate in Cancer Research and Donate Bio-Specimens," IJERPH, MDPI, vol. 15(10), pages 1-18, September.
    9. Ningyuan Guo & Ziqiu Guo & Shengzhi Zhao & Sai Yin Ho & Daniel Yee Tak Fong & Agnes Yuen Kwan Lai & Sophia Siu-chee Chan & Man Ping Wang & Tai Hing Lam, 2021. "Digital inequalities in health information seeking behaviors and experiences in the age of web 2.0: A population-based study in Hong Kong," PLOS ONE, Public Library of Science, vol. 16(3), pages 1-16, March.
    10. Li, LiLi & Zeng, Yiwu & Zhang, Zhonggen, 2020. "Impact of Internet use on Health outcomes of Rural Residents: Evidence from China," 2020 Annual Meeting, July 26-28, Kansas City, Missouri 304177, Agricultural and Applied Economics Association.
    11. Man Ping Wang & Xin Wang & Tai Hing Lam & Kasisomayajula Viswanath & Sophia S Chan, 2013. "Health Information Seeking Partially Mediated the Association between Socioeconomic Status and Self-Rated Health among Hong Kong Chinese," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-7, December.
    12. Baier, Tina & Lyngstad, Torkild Hovde, 2024. "Social Background Effects on Educational Outcomes - New Insights from Modern Genetic Science," EconStor Open Access Articles and Book Chapters, ZBW - Leibniz Information Centre for Economics, vol. 76(3), pages 525-545.
    13. Pritzker, Suzanne & Moreno, Dennise & Nicotera, Nicole & Saenz, Rebecca & Clancy, Helen & Avila, Katherine & Ruiz, Alexis & Campos, Sophia, 2024. "Promoting good trouble: Latinx youth-driven change strategies for civic engagement and activism," Children and Youth Services Review, Elsevier, vol. 164(C).
    14. Dalnim Cho & Beverly Gor & Hyunsoo Hwang & Xuemei Wang & Mike Hernandez & Lovell A. Jones & Jacqueline Frost & Pamela Roberson & Curtis A. Pettaway, 2024. "A Community-Based Prostate Cancer Screening and Education Program for Asian American Men in Medically Underserved Communities," IJERPH, MDPI, vol. 21(4), pages 1-11, March.
    15. Zamil Khadija & Alsharqi Omar, 2019. "The Effect of Information Technology on the Recruitment Process in Healthcare Organization in Makkah City," Global Journal of Health Science, Canadian Center of Science and Education, vol. 11(2), pages 123-123, February.
    16. Julia A Dalton & Dianne Rodger & Michael Wilmore & Sal Humphreys & Andrew Skuse & Claire T Roberts & Vicki L Clifton, 2018. "The Health-e Babies App for antenatal education: Feasibility for socially disadvantaged women," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-18, May.
    17. Rogério M. Pinto & Anya Y. Spector & Rahbel Rahman, 2019. "Nurturing Practitioner-Researcher Partnerships to Improve Adoption and Delivery of Research-Based Social and Public Health Services Worldwide," IJERPH, MDPI, vol. 16(5), pages 1-13, March.
    18. Richard leBrasseur, 2022. "Cultural Greenspaces: Synthesizing Knowledge and Experience in Nova Scotia’s African-Canadian Communities through Participatory Research and SoftGIS," Social Sciences, MDPI, vol. 11(7), pages 1-29, June.
    19. Donna Antoine-LaVigne & Traci Hayes & Marty Fortenberry & Evidence Ohikhuai & Clifton Addison & Sam Mozee & Dorothy McGill & Mangle L. Shanks & Christopher Roby & Brenda W. Campbell Jenkins & Paul B. , 2023. "Trust and Biomedical Research Engagement of Minority and Under-Represented Communities in Mississippi, USA," IJERPH, MDPI, vol. 20(2), pages 1-12, January.
    20. Kaitlyn E. Brodar & Marissa G. Hall & Eboneé N. Butler & Humberto Parada & Al Stein-Seroussi & Sean Hanley & Noel T. Brewer, 2016. "Recruiting Diverse Smokers: Enrollment Yields and Cost," IJERPH, MDPI, vol. 13(12), pages 1-9, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0234833. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.