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GWAS of QRS duration identifies new loci specific to Hispanic/Latino populations

Author

Listed:
  • Brenton R Swenson
  • Tin Louie
  • Henry J Lin
  • Raúl Méndez-Giráldez
  • Jennifer E Below
  • Cathy C Laurie
  • Kathleen F Kerr
  • Heather Highland
  • Timothy A Thornton
  • Kelli K Ryckman
  • Charles Kooperberg
  • Elsayed Z Soliman
  • Amanda A Seyerle
  • Xiuqing Guo
  • Kent D Taylor
  • Jie Yao
  • Susan R Heckbert
  • Dawood Darbar
  • Lauren E Petty
  • Barbara McKnight
  • Susan Cheng
  • Natalie A Bello
  • Eric A Whitsel
  • Craig L Hanis
  • Mike A Nalls
  • Daniel S Evans
  • Jerome I Rotter
  • Tamar Sofer
  • Christy L Avery
  • Nona Sotoodehnia

Abstract

Background: The electrocardiographically quantified QRS duration measures ventricular depolarization and conduction. QRS prolongation has been associated with poor heart failure prognosis and cardiovascular mortality, including sudden death. While previous genome-wide association studies (GWAS) have identified 32 QRS SNPs across 26 loci among European, African, and Asian-descent populations, the genetics of QRS among Hispanics/Latinos has not been previously explored. Methods: We performed a GWAS of QRS duration among Hispanic/Latino ancestry populations (n = 15,124) from four studies using 1000 Genomes imputed genotype data (adjusted for age, sex, global ancestry, clinical and study-specific covariates). Study-specific results were combined using fixed-effects, inverse variance-weighted meta-analysis. Results: We identified six loci associated with QRS (P

Suggested Citation

  • Brenton R Swenson & Tin Louie & Henry J Lin & Raúl Méndez-Giráldez & Jennifer E Below & Cathy C Laurie & Kathleen F Kerr & Heather Highland & Timothy A Thornton & Kelli K Ryckman & Charles Kooperberg , 2019. "GWAS of QRS duration identifies new loci specific to Hispanic/Latino populations," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-15, June.
    • Handle: RePEc:plo:pone00:0217796
    DOI: 10.1371/journal.pone.0217796
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    References listed on IDEAS

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    1. Casey E. Romanoski & Christopher K. Glass & Hendrik G. Stunnenberg & Laurence Wilson & Genevieve Almouzni, 2015. "Roadmap for regulation," Nature, Nature, vol. 518(7539), pages 314-316, February.
    2. Alice B. Popejoy & Stephanie M. Fullerton, 2016. "Genomics is failing on diversity," Nature, Nature, vol. 538(7624), pages 161-164, October.
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