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Genomic analyses of 10,376 individuals in the Westlake BioBank for Chinese (WBBC) pilot project

Author

Listed:
  • Pei-Kuan Cong

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

  • Wei-Yang Bai

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

  • Jin-Chen Li

    (Xiangya Hospital, Central South University
    Central South University
    Central South University)

  • Meng-Yuan Yang

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

  • Saber Khederzadeh

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

  • Si-Rui Gai

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

  • Nan Li

    (Westlake University)

  • Yu-Heng Liu

    (Westlake University)

  • Shi-Hui Yu

    (KingMed Diagnostics, Co., Ltd.)

  • Wei-Wei Zhao

    (KingMed Diagnostics, Co., Ltd.)

  • Jun-Quan Liu

    (KingMed Diagnostics, Co., Ltd.)

  • Yi Sun

    (KingMed Diagnostics, Co., Ltd.)

  • Xiao-Wei Zhu

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

  • Pian-Pian Zhao

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

  • Jiang-Wei Xia

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

  • Peng-Lin Guan

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

  • Yu Qian

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

  • Jian-Guo Tao

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

  • Lin Xu

    (Binzhou Medical University)

  • Geng Tian

    (Binzhou Medical University)

  • Ping-Yu Wang

    (Binzhou Medical University)

  • Shu-Yang Xie

    (Binzhou Medical University)

  • Mo-Chang Qiu

    (Jiangxi Medical College)

  • Ke-Qi Liu

    (Jiangxi Medical College)

  • Bei-Sha Tang

    (Xiangya Hospital, Central South University
    Central South University)

  • Hou-Feng Zheng

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

Abstract

We initiate the Westlake BioBank for Chinese (WBBC) pilot project with 4,535 whole-genome sequencing (WGS) individuals and 5,841 high-density genotyping individuals, and identify 81.5 million SNPs and INDELs, of which 38.5% are absent in dbSNP Build 151. We provide a population-specific reference panel and an online imputation server ( https://wbbc.westlake.edu.cn/ ) which could yield substantial improvement of imputation performance in Chinese population, especially for low-frequency and rare variants. By analyzing the singleton density of the WGS data, we find selection signatures in SNX29, DNAH1 and WDR1 genes, and the derived alleles of the alcohol metabolism genes (ADH1A and ADH1B) emerge around 7,000 years ago and tend to be more common from 4,000 years ago in East Asia. Genetic evidence supports the corresponding geographical boundaries of the Qinling-Huaihe Line and Nanling Mountains, which separate the Han Chinese into subgroups, and we reveal that North Han was more homogeneous than South Han.

Suggested Citation

  • Pei-Kuan Cong & Wei-Yang Bai & Jin-Chen Li & Meng-Yuan Yang & Saber Khederzadeh & Si-Rui Gai & Nan Li & Yu-Heng Liu & Shi-Hui Yu & Wei-Wei Zhao & Jun-Quan Liu & Yi Sun & Xiao-Wei Zhu & Pian-Pian Zhao , 2022. "Genomic analyses of 10,376 individuals in the Westlake BioBank for Chinese (WBBC) pilot project," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30526-x
    DOI: 10.1038/s41467-022-30526-x
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