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Adoptive Immunotherapy in Postoperative Hepatocellular Carcinoma: A Systemic Review

Author

Listed:
  • Feng Xie
  • Xinji Zhang
  • Hui Li
  • Tao Zheng
  • Feng Xu
  • Rongxi Shen
  • Long Yan
  • Jiamei Yang
  • Jia He

Abstract

Purpose: The effectiveness of immunotherapy for postoperative hepatocellular carcinoma patients is still controversial. To address this issue, we did a systemic review of the literatures and analyzed the data with emphasis on the recurrence and survival. Methods: We searched six randomized controlled trials that included adoptive immunotherapy in the postoperative management of hepatocellular carcinoma and compared with non-immunotherapy postoperation. A meta-analysis was carried out to examine one- and 3-year recurrence and survival. Results: The overall analysis revealed significantly reduced risk of 1-year recurrence in patients receiving adoptive immunotherapy (OR = 0.35; 95% CI, 0.17 to 0.71; p = 0.003), in that the risk of 3-year recurrence with a pooled OR estimated at 0.31 (95% CI 0.16 to 0.61; p = 0.001). However, no statistically significant difference was observed for 3-year survival between groups with adoptive immunotherapy and without adjuvant treatment (OR = 0.91; 95% CI, 0.45 to 1.84; P = 0.792). Conclusions: Adjuvant immunotherapy with cytokine induced killer cells or lymphokine activated killer cells may reduce recurrence in postoperative hepatocellular carcinoma patients, but may not improve survival.

Suggested Citation

  • Feng Xie & Xinji Zhang & Hui Li & Tao Zheng & Feng Xu & Rongxi Shen & Long Yan & Jiamei Yang & Jia He, 2012. "Adoptive Immunotherapy in Postoperative Hepatocellular Carcinoma: A Systemic Review," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-7, August.
    • Handle: RePEc:plo:pone00:0042879
    DOI: 10.1371/journal.pone.0042879
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    1. Editors The, 2008. "From the Editors," Basic Income Studies, De Gruyter, vol. 2(2), pages 1-3, January.
    2. Editors The, 2008. "From the Editors," Basic Income Studies, De Gruyter, vol. 3(1), pages 1-1, July.
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    1. Yuan Zeng & Wenli Ruan & Jiaxi He & Jianrong Zhang & Wenhua Liang & Yaoqi Chen & Qihua He & Jianxing He, 2016. "Adoptive Immunotherapy in Postoperative Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-11, September.
    2. Han-Yue Mo & Ying-Yang Liao & Xue-Mei You & Alessandro Cucchetti & Bao-Hong Yuan & Ru-Hong Li & Jian-Hong Zhong & Le-Qun Li, 2017. "Timely meta-analysis on the efficacy of adoptive immunotherapy for hepatocellular carcinoma patients after curative therapy," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-13, March.
    3. Min Ding & Ying Wang & Jiachang Chi & Tao Wang & Xiaoyin Tang & Dan Cui & Qijun Qian & Bo Zhai, 2016. "Is Adjuvant Cellular Immunotherapy Essential after TACE-Predominant Minimally-Invasive Treatment for Hepatocellular Carcinoma? A Systematic Meta-Analysis of Studies Including 1774 Patients," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-13, December.

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