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Timely meta-analysis on the efficacy of adoptive immunotherapy for hepatocellular carcinoma patients after curative therapy

Author

Listed:
  • Han-Yue Mo
  • Ying-Yang Liao
  • Xue-Mei You
  • Alessandro Cucchetti
  • Bao-Hong Yuan
  • Ru-Hong Li
  • Jian-Hong Zhong
  • Le-Qun Li

Abstract

Aims: The role of adoptive immunotherapy (AIT) for patients with hepatocellular carcinoma (HCC) who have received curative therapy is still not well illustrated. This timely meta-analysis aims to update the current evidence on efficacy and safety of AIT for patients with HCC who have received curative therapy. Methods: We searched PubMed, EMBASE, Scopus and the Cochrane Library Through January 2017 for relevant studies. Mortality and tumor recurrence were compared between patients with or without adjuvant AIT. The meta-analysis was performed using Review Manager 5.3. Results: Eight studies involving 1861 patients met the eligibility criteria and were meta-analyzed. Adjuvant AIT was associated with significantly lower mortality at 1 year (RR 0.64, 95%CI 0.52–0.79), 3 years (RR 0.73, 95%CI 0.65–0.81) and 5 years (RR 0.86, 95%CI 0.79–0.94). Similarly, adjuvant AIT was associated with significantly lower recurrence rate than curative therapies alone at 1 year (RR 0.64, 95%CI 0.49–0.82), 3 years (RR 0.85, 95%CI 0.79–0.91) and 5 years (RR 0.90, 95%CI 0.85–0.95). Short-term outcomes were confirmed in sensitivity analyses based on randomized trials or choice of random- or fixed-effect meta-analysis model. None of the included patients experienced grade 4 adverse events. Conclusions: This timely meta-analysis confirms the evidence that adjuvant AIT for patients with HCC after curative treatment lowers risk of mortality and tumor recurrence.

Suggested Citation

  • Han-Yue Mo & Ying-Yang Liao & Xue-Mei You & Alessandro Cucchetti & Bao-Hong Yuan & Ru-Hong Li & Jian-Hong Zhong & Le-Qun Li, 2017. "Timely meta-analysis on the efficacy of adoptive immunotherapy for hepatocellular carcinoma patients after curative therapy," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-13, March.
    • Handle: RePEc:plo:pone00:0174222
    DOI: 10.1371/journal.pone.0174222
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    References listed on IDEAS

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    1. Feng Xie & Xinji Zhang & Hui Li & Tao Zheng & Feng Xu & Rongxi Shen & Long Yan & Jiamei Yang & Jia He, 2012. "Adoptive Immunotherapy in Postoperative Hepatocellular Carcinoma: A Systemic Review," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-7, August.
    2. Jian-Hong Zhong & Xin-Shao Mo & Bang-De Xiang & Wei-Ping Yuan & Jin-Fang Jiang & Gui-Sheng Xie & Le-Qun Li, 2013. "Postoperative Use of the Chemopreventive Vitamin K2 Analog in Patients with Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-8, March.
    3. Min Ding & Ying Wang & Jiachang Chi & Tao Wang & Xiaoyin Tang & Dan Cui & Qijun Qian & Bo Zhai, 2016. "Is Adjuvant Cellular Immunotherapy Essential after TACE-Predominant Minimally-Invasive Treatment for Hepatocellular Carcinoma? A Systematic Meta-Analysis of Studies Including 1774 Patients," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-13, December.
    4. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
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