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Significant sparse polygenic risk scores across 813 traits in UK Biobank

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Listed:
  • Yosuke Tanigawa
  • Junyang Qian
  • Guhan Venkataraman
  • Johanne Marie Justesen
  • Ruilin Li
  • Robert Tibshirani
  • Trevor Hastie
  • Manuel A Rivas

Abstract

We present a systematic assessment of polygenic risk score (PRS) prediction across more than 1,500 traits using genetic and phenotype data in the UK Biobank. We report 813 sparse PRS models with significant (p

Suggested Citation

  • Yosuke Tanigawa & Junyang Qian & Guhan Venkataraman & Johanne Marie Justesen & Ruilin Li & Robert Tibshirani & Trevor Hastie & Manuel A Rivas, 2022. "Significant sparse polygenic risk scores across 813 traits in UK Biobank," PLOS Genetics, Public Library of Science, vol. 18(3), pages 1-21, March.
    • Handle: RePEc:plo:pgen00:1010105
    DOI: 10.1371/journal.pgen.1010105
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    1. Anders M. Fjell & Øystein Sørensen & Yunpeng Wang & Inge K. Amlien & William F. C. Baaré & David Bartrés-Faz & Lars Bertram & Carl-Johan Boraxbekk & Andreas M. Brandmaier & Ilja Demuth & Christian A. , 2023. "No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy," Nature Human Behaviour, Nature, vol. 7(11), pages 2008-2022, November.
    2. Rikifumi Ohta & Yosuke Tanigawa & Yuta Suzuki & Manolis Kellis & Shinichi Morishita, 2024. "A polygenic score method boosted by non-additive models," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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