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The contribution of common and rare genetic variants to variation in metabolic traits in 288,137 East Asians

Author

Listed:
  • Young Jin Kim

    (National Institute of Health)

  • Sanghoon Moon

    (National Institute of Health)

  • Mi Yeong Hwang

    (National Institute of Health)

  • Sohee Han

    (National Institute of Health)

  • Hye-Mi Jang

    (National Institute of Health)

  • Jinhwa Kong

    (National Institute of Health)

  • Dong Mun Shin

    (National Institute of Health)

  • Kyungheon Yoon

    (National Institute of Health)

  • Sung Min Kim

    (National Institute of Health)

  • Jong-Eun Lee

    (DNALink)

  • Anubha Mahajan

    (Genentech, 1 DNA Way
    University of Oxford)

  • Hyun-Young Park

    (National Institute of Health)

  • Mark I. McCarthy

    (Genentech, 1 DNA Way
    University of Oxford)

  • Yoon Shin Cho

    (Hallym University)

  • Bong-Jo Kim

    (National Institute of Health)

Abstract

Metabolic traits are heritable phenotypes widely-used in assessing the risk of various diseases. We conduct a genome-wide association analysis (GWAS) of nine metabolic traits (including glycemic, lipid, liver enzyme levels) in 125,872 Korean subjects genotyped with the Korea Biobank Array. Following meta-analysis with GWAS from Biobank Japan identify 144 novel signals (MAF ≥ 1%), of which 57.0% are replicated in UK Biobank. Additionally, we discover 66 rare (MAF

Suggested Citation

  • Young Jin Kim & Sanghoon Moon & Mi Yeong Hwang & Sohee Han & Hye-Mi Jang & Jinhwa Kong & Dong Mun Shin & Kyungheon Yoon & Sung Min Kim & Jong-Eun Lee & Anubha Mahajan & Hyun-Young Park & Mark I. McCar, 2022. "The contribution of common and rare genetic variants to variation in metabolic traits in 288,137 East Asians," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34163-2
    DOI: 10.1038/s41467-022-34163-2
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    1. Chamlee Cho & Beomsu Kim & Dan Say Kim & Mi Yeong Hwang & Injeong Shim & Minku Song & Yeong Chan Lee & Sang-Hyuk Jung & Sung Kweon Cho & Woong-Yang Park & Woojae Myung & Bong-Jo Kim & Ron Do & Hyon K., 2024. "Large-scale cross-ancestry genome-wide meta-analysis of serum urate," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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