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Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression

Author

Listed:
  • Peter Zhukovsky

    (Centre for Addiction and Mental Health
    University of Toronto
    Centre for Addiction and Mental Health)

  • Earvin S. Tio

    (Centre for Addiction and Mental Health
    University of Toronto)

  • Gillian Coughlan

    (Massachusetts General Hospital)

  • David A. Bennett

    (RUSH Medical College)

  • Yanling Wang

    (RUSH Medical College)

  • Timothy J. Hohman

    (Vanderbilt University Medical Center
    Vanderbilt University Medical Center)

  • Diego A. Pizzagalli

    (McLean Hospital)

  • Benoit H. Mulsant

    (Centre for Addiction and Mental Health
    University of Toronto)

  • Aristotle N. Voineskos

    (Centre for Addiction and Mental Health
    University of Toronto)

  • Daniel Felsky

    (University of Toronto
    Centre for Addiction and Mental Health
    University of Toronto
    University of Toronto)

Abstract

Approximately 40% of dementia cases could be prevented or delayed by modifiable risk factors related to lifestyle and environment. These risk factors, such as depression and vascular disease, do not affect all individuals in the same way, likely due to inter-individual differences in genetics. However, the precise nature of how genetic risk profiles interact with modifiable risk factors to affect brain health is poorly understood. Here we combine multiple data resources, including genotyping and postmortem gene expression, to map the genetic landscape of brain structure and identify 367 loci associated with cortical thickness and 13 loci associated with white matter hyperintensities (P

Suggested Citation

  • Peter Zhukovsky & Earvin S. Tio & Gillian Coughlan & David A. Bennett & Yanling Wang & Timothy J. Hohman & Diego A. Pizzagalli & Benoit H. Mulsant & Aristotle N. Voineskos & Daniel Felsky, 2024. "Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49430-7
    DOI: 10.1038/s41467-024-49430-7
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    as
    1. Edith Hofer & Gennady V. Roshchupkin & Hieab H. H. Adams & Maria J. Knol & Honghuang Lin & Shuo Li & Habil Zare & Shahzad Ahmad & Nicola J. Armstrong & Claudia L. Satizabal & Manon Bernard & Joshua C., 2020. "Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    2. Yosuke Tanigawa & Jiehan Li & Johanne M. Justesen & Heiko Horn & Matthew Aguirre & Christopher DeBoever & Chris Chang & Balasubramanian Narasimhan & Kasper Lage & Trevor Hastie & Chong Y. Park & Gill , 2019. "Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    3. Xueyi Shen & David M. Howard & Mark J. Adams & W. David Hill & Toni-Kim Clarke & Ian J. Deary & Heather C. Whalley & Andrew M. McIntosh, 2020. "A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    4. Lloyd T. Elliott & Kevin Sharp & Fidel Alfaro-Almagro & Sinan Shi & Karla L. Miller & Gwenaëlle Douaud & Jonathan Marchini & Stephen M. Smith, 2018. "Genome-wide association studies of brain imaging phenotypes in UK Biobank," Nature, Nature, vol. 562(7726), pages 210-216, October.
    5. Clare Bycroft & Colin Freeman & Desislava Petkova & Gavin Band & Lloyd T. Elliott & Kevin Sharp & Allan Motyer & Damjan Vukcevic & Olivier Delaneau & Jared O’Connell & Adrian Cortes & Samantha Welsh &, 2018. "The UK Biobank resource with deep phenotyping and genomic data," Nature, Nature, vol. 562(7726), pages 203-209, October.
    6. Matthew F. Glasser & Timothy S. Coalson & Emma C. Robinson & Carl D. Hacker & John Harwell & Essa Yacoub & Kamil Ugurbil & Jesper Andersson & Christian F. Beckmann & Mark Jenkinson & Stephen M. Smith , 2016. "A multi-modal parcellation of human cerebral cortex," Nature, Nature, vol. 536(7615), pages 171-178, August.
    7. Kyoko Watanabe & Erdogan Taskesen & Arjen Bochoven & Danielle Posthuma, 2017. "Functional mapping and annotation of genetic associations with FUMA," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    8. Kenneth E. Westerman & Timothy D. Majarian & Franco Giulianini & Dong-Keun Jang & Jenkai Miao & Jose C. Florez & Han Chen & Daniel I. Chasman & Miriam S. Udler & Alisa K. Manning & Joanne B. Cole, 2022. "Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    9. Elodie Persyn & Ken B. Hanscombe & Joanna M. M. Howson & Cathryn M. Lewis & Matthew Traylor & Hugh S. Markus, 2020. "Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

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